Awareness of incurable cancer status and health-related quality of life among advanced cancer patients: A prospective cohort study

Myung Kyung Lee, Sun Kyung Baek, Si Young Kim, Dae Seog Heo, Young Ho Yun, Sook Ryun Park, Jun Suk Kim

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background: Many patients near death report an interest in knowing their prognoses. Patients' awareness of disease status may lead to more appropriate care and maintained or improved quality of life. However, it is not known whether advanced cancer patients' awareness of disease status is associated with patients' quality of life. Aim: We aimed to examine the effect of patients' awareness of disease status on the health-related quality of life (HRQOL) among advanced cancer patients undergoing palliative chemotherapy. Design: In this prospective cohort study, patients were followed-up at 46 weeks and 23 months after the initial palliative chemotherapy. Patients' awareness of disease status, and demographic and clinical characteristics were assessed at baseline, and depression and anxiety using the Hospital Anxiety and Depression Scale (HADS) and HRQOL using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) were assessed three times. Setting / participants: In total, 100 patients with advanced cancer starting palliative chemotherapy were recruited from two tertiary university hospitals and from the Korea National Cancer Center. Results: Patients with advanced cancer undergoing palliative chemotherapy experienced deteriorated HRQOL. Of these, the patients who were aware of their disease status as incurable had significantly higher role (p=0.002), emotional (p=0.025), and social functioning (p=0.002), and lower fatigue (p=0.008), appetite loss (p=0.039), constipation (p=0.032), financial difficulties (p=0.019), and anxiety (p=0.041) compared with patients unaware of disease status. Conclusion: Our findings demonstrate the importance of patients' awareness of disease status to HRQOL.

Original languageEnglish
Pages (from-to)144-154
Number of pages11
JournalPalliative Medicine
Volume27
Issue number2
DOIs
Publication statusPublished - 2013 Feb 1

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Cohort Studies
Quality of Life
Prospective Studies
Neoplasms
Drug Therapy
Anxiety
Depression
Appetite
Constipation
Korea
Tertiary Care Centers
Fatigue
Demography
Organizations

Keywords

  • awareness
  • disease status
  • incurable cancer
  • prospective cohort study
  • quality of life

ASJC Scopus subject areas

  • Medicine(all)
  • Anesthesiology and Pain Medicine

Cite this

Awareness of incurable cancer status and health-related quality of life among advanced cancer patients : A prospective cohort study. / Lee, Myung Kyung; Baek, Sun Kyung; Kim, Si Young; Heo, Dae Seog; Yun, Young Ho; Park, Sook Ryun; Kim, Jun Suk.

In: Palliative Medicine, Vol. 27, No. 2, 01.02.2013, p. 144-154.

Research output: Contribution to journalArticle

Lee, Myung Kyung ; Baek, Sun Kyung ; Kim, Si Young ; Heo, Dae Seog ; Yun, Young Ho ; Park, Sook Ryun ; Kim, Jun Suk. / Awareness of incurable cancer status and health-related quality of life among advanced cancer patients : A prospective cohort study. In: Palliative Medicine. 2013 ; Vol. 27, No. 2. pp. 144-154.
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