Abstract
Convoluted cortical folding and neuronal wiring are 2 prominent attributes of the mammalian brain. However, the macroscale intrinsic relationship between these 2 general cross-species attributes, as well as the underlying principles that sculpt the architecture of the cerebral cortex, remains unclear. Here, we show that the axonal fibers connected to gyri are significantly denser than those connected to sulci. In human, chimpanzee, and macaque brains, a dominant fraction of axonal fibers were found to be connected to the gyri. This finding has been replicated in a range of mammalian brains via diffusion tensor imaging and high-angular resolution diffusion imaging. These results may have shed some lights on fundamental mechanisms for development and organization of the cerebral cortex, suggesting that axonal pushing is a mechanism of cortical folding.
| Original language | English |
|---|---|
| Pages (from-to) | 2831-2839 |
| Number of pages | 9 |
| Journal | Cerebral Cortex |
| Volume | 22 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 2012 Dec 1 |
| Externally published | Yes |
Fingerprint
Keywords
- cortical folding
- diffusion tensor imaging
- shape analysis
ASJC Scopus subject areas
- Cognitive Neuroscience
- Cellular and Molecular Neuroscience
Cite this
Axonal fiber terminations concentrate on gyri. / Nie, Jingxin; Guo, Lei; Li, Kaiming; Wang, Yonghua; Chen, Guojun; Li, Longchuan; Chen, Hanbo; Deng, Fan; Jiang, Xi; Zhang, Tuo; Huang, Ling; Faraco, Carlos; Zhang, Degang; Guo, Cong; Yap, Pew Thian; Hu, Xintao; Li, Gang; Lv, Jinglei; Yuan, Yixuan; Zhu, Dajiang; Han, Junwei; Sabatinelli, Dean; Zhao, Qun; Miller, L. Stephen; Xu, Bingqian; Shen, Ping; Platt, Simon; Shen, Dinggang; Hu, Xiaoping; Liu, Tianming.
In: Cerebral Cortex, Vol. 22, No. 12, 01.12.2012, p. 2831-2839.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Axonal fiber terminations concentrate on gyri
AU - Nie, Jingxin
AU - Guo, Lei
AU - Li, Kaiming
AU - Wang, Yonghua
AU - Chen, Guojun
AU - Li, Longchuan
AU - Chen, Hanbo
AU - Deng, Fan
AU - Jiang, Xi
AU - Zhang, Tuo
AU - Huang, Ling
AU - Faraco, Carlos
AU - Zhang, Degang
AU - Guo, Cong
AU - Yap, Pew Thian
AU - Hu, Xintao
AU - Li, Gang
AU - Lv, Jinglei
AU - Yuan, Yixuan
AU - Zhu, Dajiang
AU - Han, Junwei
AU - Sabatinelli, Dean
AU - Zhao, Qun
AU - Miller, L. Stephen
AU - Xu, Bingqian
AU - Shen, Ping
AU - Platt, Simon
AU - Shen, Dinggang
AU - Hu, Xiaoping
AU - Liu, Tianming
PY - 2012/12/1
Y1 - 2012/12/1
N2 - Convoluted cortical folding and neuronal wiring are 2 prominent attributes of the mammalian brain. However, the macroscale intrinsic relationship between these 2 general cross-species attributes, as well as the underlying principles that sculpt the architecture of the cerebral cortex, remains unclear. Here, we show that the axonal fibers connected to gyri are significantly denser than those connected to sulci. In human, chimpanzee, and macaque brains, a dominant fraction of axonal fibers were found to be connected to the gyri. This finding has been replicated in a range of mammalian brains via diffusion tensor imaging and high-angular resolution diffusion imaging. These results may have shed some lights on fundamental mechanisms for development and organization of the cerebral cortex, suggesting that axonal pushing is a mechanism of cortical folding.
AB - Convoluted cortical folding and neuronal wiring are 2 prominent attributes of the mammalian brain. However, the macroscale intrinsic relationship between these 2 general cross-species attributes, as well as the underlying principles that sculpt the architecture of the cerebral cortex, remains unclear. Here, we show that the axonal fibers connected to gyri are significantly denser than those connected to sulci. In human, chimpanzee, and macaque brains, a dominant fraction of axonal fibers were found to be connected to the gyri. This finding has been replicated in a range of mammalian brains via diffusion tensor imaging and high-angular resolution diffusion imaging. These results may have shed some lights on fundamental mechanisms for development and organization of the cerebral cortex, suggesting that axonal pushing is a mechanism of cortical folding.
KW - cortical folding
KW - diffusion tensor imaging
KW - shape analysis
UR - http://www.scopus.com/inward/record.url?scp=84869015890&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84869015890&partnerID=8YFLogxK
U2 - 10.1093/cercor/bhr361
DO - 10.1093/cercor/bhr361
M3 - Article
C2 - 22190432
AN - SCOPUS:84869015890
VL - 22
SP - 2831
EP - 2839
JO - Cerebral Cortex
JF - Cerebral Cortex
SN - 1047-3211
IS - 12
ER -