Axonal fiber terminations concentrate on gyri

Jingxin Nie, Lei Guo, Kaiming Li, Yonghua Wang, Guojun Chen, Longchuan Li, Hanbo Chen, Fan Deng, Xi Jiang, Tuo Zhang, Ling Huang, Carlos Faraco, Degang Zhang, Cong Guo, Pew Thian Yap, Xintao Hu, Gang Li, Jinglei Lv, Yixuan Yuan, Dajiang ZhuJunwei Han, Dean Sabatinelli, Qun Zhao, L. Stephen Miller, Bingqian Xu, Ping Shen, Simon Platt, Dinggang Shen, Xiaoping Hu, Tianming Liu

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Convoluted cortical folding and neuronal wiring are 2 prominent attributes of the mammalian brain. However, the macroscale intrinsic relationship between these 2 general cross-species attributes, as well as the underlying principles that sculpt the architecture of the cerebral cortex, remains unclear. Here, we show that the axonal fibers connected to gyri are significantly denser than those connected to sulci. In human, chimpanzee, and macaque brains, a dominant fraction of axonal fibers were found to be connected to the gyri. This finding has been replicated in a range of mammalian brains via diffusion tensor imaging and high-angular resolution diffusion imaging. These results may have shed some lights on fundamental mechanisms for development and organization of the cerebral cortex, suggesting that axonal pushing is a mechanism of cortical folding.

Original languageEnglish
Pages (from-to)2831-2839
Number of pages9
JournalCerebral Cortex
Volume22
Issue number12
DOIs
Publication statusPublished - 2012 Dec 1
Externally publishedYes

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Keywords

  • cortical folding
  • diffusion tensor imaging
  • shape analysis

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Nie, J., Guo, L., Li, K., Wang, Y., Chen, G., Li, L., Chen, H., Deng, F., Jiang, X., Zhang, T., Huang, L., Faraco, C., Zhang, D., Guo, C., Yap, P. T., Hu, X., Li, G., Lv, J., Yuan, Y., ... Liu, T. (2012). Axonal fiber terminations concentrate on gyri. Cerebral Cortex, 22(12), 2831-2839. https://doi.org/10.1093/cercor/bhr361