Axonal fiber terminations concentrate on gyri

Jingxin Nie; Lei Guo; Kaiming Li; Yonghua Wang; Guojun Chen; Longchuan Li; Hanbo Chen; Fan Deng; Xi Jiang; Tuo Zhang; Ling Huang; Carlos Faraco; Degang Zhang; Cong Guo; Pew Thian Yap; Xintao Hu; Gang Li; Jinglei Lv; Yixuan Yuan; Dajiang Zhu; Junwei Han; Dean Sabatinelli; Qun Zhao; L. Stephen Miller; Bingqian Xu; Ping Shen; Simon Platt; Dinggang Shen; Xiaoping Hu; Tianming Liu

doi:10.1093/cercor/bhr361

Axonal fiber terminations concentrate on gyri

Jingxin Nie, Lei Guo, Kaiming Li, Yonghua Wang, Guojun Chen, Longchuan Li, Hanbo Chen, Fan Deng, Xi Jiang, Tuo Zhang, Ling Huang, Carlos Faraco, Degang Zhang, Cong Guo, Pew Thian Yap, Xintao Hu, Gang Li, Jinglei Lv, Yixuan Yuan, Dajiang ZhuJunwei Han, Dean Sabatinelli, Qun Zhao, L. Stephen Miller, Bingqian Xu, Ping Shen, Simon Platt, Dinggang Shen, Xiaoping Hu, Tianming Liu

Research output: Contribution to journal › Article › peer-review

69 Citations (Scopus)

Abstract

Convoluted cortical folding and neuronal wiring are 2 prominent attributes of the mammalian brain. However, the macroscale intrinsic relationship between these 2 general cross-species attributes, as well as the underlying principles that sculpt the architecture of the cerebral cortex, remains unclear. Here, we show that the axonal fibers connected to gyri are significantly denser than those connected to sulci. In human, chimpanzee, and macaque brains, a dominant fraction of axonal fibers were found to be connected to the gyri. This finding has been replicated in a range of mammalian brains via diffusion tensor imaging and high-angular resolution diffusion imaging. These results may have shed some lights on fundamental mechanisms for development and organization of the cerebral cortex, suggesting that axonal pushing is a mechanism of cortical folding.

Original language	English
Pages (from-to)	2831-2839
Number of pages	9
Journal	Cerebral Cortex
Volume	22
Issue number	12
DOIs	https://doi.org/10.1093/cercor/bhr361
Publication status	Published - 2012 Dec
Externally published	Yes

Keywords

cortical folding
diffusion tensor imaging
shape analysis

ASJC Scopus subject areas

Cognitive Neuroscience
Cellular and Molecular Neuroscience

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10.1093/cercor/bhr361

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Axonal fiber terminations concentrate on gyri. / Nie, Jingxin; Guo, Lei; Li, Kaiming; Wang, Yonghua; Chen, Guojun; Li, Longchuan; Chen, Hanbo; Deng, Fan; Jiang, Xi; Zhang, Tuo; Huang, Ling; Faraco, Carlos; Zhang, Degang; Guo, Cong; Yap, Pew Thian; Hu, Xintao; Li, Gang; Lv, Jinglei; Yuan, Yixuan; Zhu, Dajiang; Han, Junwei; Sabatinelli, Dean; Zhao, Qun; Miller, L. Stephen; Xu, Bingqian; Shen, Ping; Platt, Simon; Shen, Dinggang; Hu, Xiaoping; Liu, Tianming.

In: Cerebral Cortex, Vol. 22, No. 12, 12.2012, p. 2831-2839.

Research output: Contribution to journal › Article › peer-review

Nie, J, Guo, L, Li, K, Wang, Y, Chen, G, Li, L, Chen, H, Deng, F, Jiang, X, Zhang, T, Huang, L, Faraco, C, Zhang, D, Guo, C, Yap, PT, Hu, X, Li, G, Lv, J, Yuan, Y, Zhu, D, Han, J, Sabatinelli, D, Zhao, Q, Miller, LS, Xu, B, Shen, P, Platt, S, Shen, D, Hu, X & Liu, T 2012, 'Axonal fiber terminations concentrate on gyri', Cerebral Cortex, vol. 22, no. 12, pp. 2831-2839. https://doi.org/10.1093/cercor/bhr361

Nie, Jingxin ; Guo, Lei ; Li, Kaiming ; Wang, Yonghua ; Chen, Guojun ; Li, Longchuan ; Chen, Hanbo ; Deng, Fan ; Jiang, Xi ; Zhang, Tuo ; Huang, Ling ; Faraco, Carlos ; Zhang, Degang ; Guo, Cong ; Yap, Pew Thian ; Hu, Xintao ; Li, Gang ; Lv, Jinglei ; Yuan, Yixuan ; Zhu, Dajiang ; Han, Junwei ; Sabatinelli, Dean ; Zhao, Qun ; Miller, L. Stephen ; Xu, Bingqian ; Shen, Ping ; Platt, Simon ; Shen, Dinggang ; Hu, Xiaoping ; Liu, Tianming. / Axonal fiber terminations concentrate on gyri. In: Cerebral Cortex. 2012 ; Vol. 22, No. 12. pp. 2831-2839.

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title = "Axonal fiber terminations concentrate on gyri",

abstract = "Convoluted cortical folding and neuronal wiring are 2 prominent attributes of the mammalian brain. However, the macroscale intrinsic relationship between these 2 general cross-species attributes, as well as the underlying principles that sculpt the architecture of the cerebral cortex, remains unclear. Here, we show that the axonal fibers connected to gyri are significantly denser than those connected to sulci. In human, chimpanzee, and macaque brains, a dominant fraction of axonal fibers were found to be connected to the gyri. This finding has been replicated in a range of mammalian brains via diffusion tensor imaging and high-angular resolution diffusion imaging. These results may have shed some lights on fundamental mechanisms for development and organization of the cerebral cortex, suggesting that axonal pushing is a mechanism of cortical folding.",

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author = "Jingxin Nie and Lei Guo and Kaiming Li and Yonghua Wang and Guojun Chen and Longchuan Li and Hanbo Chen and Fan Deng and Xi Jiang and Tuo Zhang and Ling Huang and Carlos Faraco and Degang Zhang and Cong Guo and Yap, {Pew Thian} and Xintao Hu and Gang Li and Jinglei Lv and Yixuan Yuan and Dajiang Zhu and Junwei Han and Dean Sabatinelli and Qun Zhao and Miller, {L. Stephen} and Bingqian Xu and Ping Shen and Simon Platt and Dinggang Shen and Xiaoping Hu and Tianming Liu",

note = "Funding Information: Northwestern Polytechnic University Foundation for Fundamental Research to J. Nie, L. Guo, and G. Li; National Institutes of Health (K01 EB 006878 and R01 HL087923-03S2 to T. Liu, PO1 AG026423 to L. Li and X. Hu); The University of Georgia start-up research funding to T. Liu; China Government Scholarship to K. Li, T. Zhang, and D. Zhang.",

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doi = "10.1093/cercor/bhr361",

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AU - Nie, Jingxin

AU - Guo, Lei

AU - Li, Kaiming

AU - Wang, Yonghua

AU - Chen, Guojun

AU - Li, Longchuan

AU - Chen, Hanbo

AU - Deng, Fan

AU - Jiang, Xi

AU - Zhang, Tuo

AU - Huang, Ling

AU - Faraco, Carlos

AU - Zhang, Degang

AU - Guo, Cong

AU - Yap, Pew Thian

AU - Hu, Xintao

AU - Li, Gang

AU - Lv, Jinglei

AU - Yuan, Yixuan

AU - Zhu, Dajiang

AU - Han, Junwei

AU - Sabatinelli, Dean

AU - Zhao, Qun

AU - Miller, L. Stephen

AU - Xu, Bingqian

AU - Shen, Ping

AU - Platt, Simon

AU - Shen, Dinggang

AU - Hu, Xiaoping

AU - Liu, Tianming

N1 - Funding Information: Northwestern Polytechnic University Foundation for Fundamental Research to J. Nie, L. Guo, and G. Li; National Institutes of Health (K01 EB 006878 and R01 HL087923-03S2 to T. Liu, PO1 AG026423 to L. Li and X. Hu); The University of Georgia start-up research funding to T. Liu; China Government Scholarship to K. Li, T. Zhang, and D. Zhang.

PY - 2012/12

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