Axonal fiber terminations concentrate on gyri

Jingxin Nie, Lei Guo, Kaiming Li, Yonghua Wang, Guojun Chen, Longchuan Li, Hanbo Chen, Fan Deng, Xi Jiang, Tuo Zhang, Ling Huang, Carlos Faraco, Degang Zhang, Cong Guo, Pew Thian Yap, Xintao Hu, Gang Li, Jinglei Lv, Yixuan Yuan, Dajiang ZhuJunwei Han, Dean Sabatinelli, Qun Zhao, L. Stephen Miller, Bingqian Xu, Ping Shen, Simon Platt, Dinggang Shen, Xiaoping Hu, Tianming Liu

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Convoluted cortical folding and neuronal wiring are 2 prominent attributes of the mammalian brain. However, the macroscale intrinsic relationship between these 2 general cross-species attributes, as well as the underlying principles that sculpt the architecture of the cerebral cortex, remains unclear. Here, we show that the axonal fibers connected to gyri are significantly denser than those connected to sulci. In human, chimpanzee, and macaque brains, a dominant fraction of axonal fibers were found to be connected to the gyri. This finding has been replicated in a range of mammalian brains via diffusion tensor imaging and high-angular resolution diffusion imaging. These results may have shed some lights on fundamental mechanisms for development and organization of the cerebral cortex, suggesting that axonal pushing is a mechanism of cortical folding.

Original languageEnglish
Pages (from-to)2831-2839
Number of pages9
JournalCerebral Cortex
Volume22
Issue number12
DOIs
Publication statusPublished - 2012 Dec 1
Externally publishedYes

Fingerprint

Cerebral Cortex
Brain
Diffusion Tensor Imaging
Pan troglodytes
Macaca
Light

Keywords

  • cortical folding
  • diffusion tensor imaging
  • shape analysis

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Nie, J., Guo, L., Li, K., Wang, Y., Chen, G., Li, L., ... Liu, T. (2012). Axonal fiber terminations concentrate on gyri. Cerebral Cortex, 22(12), 2831-2839. https://doi.org/10.1093/cercor/bhr361

Axonal fiber terminations concentrate on gyri. / Nie, Jingxin; Guo, Lei; Li, Kaiming; Wang, Yonghua; Chen, Guojun; Li, Longchuan; Chen, Hanbo; Deng, Fan; Jiang, Xi; Zhang, Tuo; Huang, Ling; Faraco, Carlos; Zhang, Degang; Guo, Cong; Yap, Pew Thian; Hu, Xintao; Li, Gang; Lv, Jinglei; Yuan, Yixuan; Zhu, Dajiang; Han, Junwei; Sabatinelli, Dean; Zhao, Qun; Miller, L. Stephen; Xu, Bingqian; Shen, Ping; Platt, Simon; Shen, Dinggang; Hu, Xiaoping; Liu, Tianming.

In: Cerebral Cortex, Vol. 22, No. 12, 01.12.2012, p. 2831-2839.

Research output: Contribution to journalArticle

Nie, J, Guo, L, Li, K, Wang, Y, Chen, G, Li, L, Chen, H, Deng, F, Jiang, X, Zhang, T, Huang, L, Faraco, C, Zhang, D, Guo, C, Yap, PT, Hu, X, Li, G, Lv, J, Yuan, Y, Zhu, D, Han, J, Sabatinelli, D, Zhao, Q, Miller, LS, Xu, B, Shen, P, Platt, S, Shen, D, Hu, X & Liu, T 2012, 'Axonal fiber terminations concentrate on gyri', Cerebral Cortex, vol. 22, no. 12, pp. 2831-2839. https://doi.org/10.1093/cercor/bhr361
Nie J, Guo L, Li K, Wang Y, Chen G, Li L et al. Axonal fiber terminations concentrate on gyri. Cerebral Cortex. 2012 Dec 1;22(12):2831-2839. https://doi.org/10.1093/cercor/bhr361
Nie, Jingxin ; Guo, Lei ; Li, Kaiming ; Wang, Yonghua ; Chen, Guojun ; Li, Longchuan ; Chen, Hanbo ; Deng, Fan ; Jiang, Xi ; Zhang, Tuo ; Huang, Ling ; Faraco, Carlos ; Zhang, Degang ; Guo, Cong ; Yap, Pew Thian ; Hu, Xintao ; Li, Gang ; Lv, Jinglei ; Yuan, Yixuan ; Zhu, Dajiang ; Han, Junwei ; Sabatinelli, Dean ; Zhao, Qun ; Miller, L. Stephen ; Xu, Bingqian ; Shen, Ping ; Platt, Simon ; Shen, Dinggang ; Hu, Xiaoping ; Liu, Tianming. / Axonal fiber terminations concentrate on gyri. In: Cerebral Cortex. 2012 ; Vol. 22, No. 12. pp. 2831-2839.
@article{f38a814da15348a8900784550a746cb8,
title = "Axonal fiber terminations concentrate on gyri",
abstract = "Convoluted cortical folding and neuronal wiring are 2 prominent attributes of the mammalian brain. However, the macroscale intrinsic relationship between these 2 general cross-species attributes, as well as the underlying principles that sculpt the architecture of the cerebral cortex, remains unclear. Here, we show that the axonal fibers connected to gyri are significantly denser than those connected to sulci. In human, chimpanzee, and macaque brains, a dominant fraction of axonal fibers were found to be connected to the gyri. This finding has been replicated in a range of mammalian brains via diffusion tensor imaging and high-angular resolution diffusion imaging. These results may have shed some lights on fundamental mechanisms for development and organization of the cerebral cortex, suggesting that axonal pushing is a mechanism of cortical folding.",
keywords = "cortical folding, diffusion tensor imaging, shape analysis",
author = "Jingxin Nie and Lei Guo and Kaiming Li and Yonghua Wang and Guojun Chen and Longchuan Li and Hanbo Chen and Fan Deng and Xi Jiang and Tuo Zhang and Ling Huang and Carlos Faraco and Degang Zhang and Cong Guo and Yap, {Pew Thian} and Xintao Hu and Gang Li and Jinglei Lv and Yixuan Yuan and Dajiang Zhu and Junwei Han and Dean Sabatinelli and Qun Zhao and Miller, {L. Stephen} and Bingqian Xu and Ping Shen and Simon Platt and Dinggang Shen and Xiaoping Hu and Tianming Liu",
year = "2012",
month = "12",
day = "1",
doi = "10.1093/cercor/bhr361",
language = "English",
volume = "22",
pages = "2831--2839",
journal = "Cerebral Cortex",
issn = "1047-3211",
publisher = "Oxford University Press",
number = "12",

}

TY - JOUR

T1 - Axonal fiber terminations concentrate on gyri

AU - Nie, Jingxin

AU - Guo, Lei

AU - Li, Kaiming

AU - Wang, Yonghua

AU - Chen, Guojun

AU - Li, Longchuan

AU - Chen, Hanbo

AU - Deng, Fan

AU - Jiang, Xi

AU - Zhang, Tuo

AU - Huang, Ling

AU - Faraco, Carlos

AU - Zhang, Degang

AU - Guo, Cong

AU - Yap, Pew Thian

AU - Hu, Xintao

AU - Li, Gang

AU - Lv, Jinglei

AU - Yuan, Yixuan

AU - Zhu, Dajiang

AU - Han, Junwei

AU - Sabatinelli, Dean

AU - Zhao, Qun

AU - Miller, L. Stephen

AU - Xu, Bingqian

AU - Shen, Ping

AU - Platt, Simon

AU - Shen, Dinggang

AU - Hu, Xiaoping

AU - Liu, Tianming

PY - 2012/12/1

Y1 - 2012/12/1

N2 - Convoluted cortical folding and neuronal wiring are 2 prominent attributes of the mammalian brain. However, the macroscale intrinsic relationship between these 2 general cross-species attributes, as well as the underlying principles that sculpt the architecture of the cerebral cortex, remains unclear. Here, we show that the axonal fibers connected to gyri are significantly denser than those connected to sulci. In human, chimpanzee, and macaque brains, a dominant fraction of axonal fibers were found to be connected to the gyri. This finding has been replicated in a range of mammalian brains via diffusion tensor imaging and high-angular resolution diffusion imaging. These results may have shed some lights on fundamental mechanisms for development and organization of the cerebral cortex, suggesting that axonal pushing is a mechanism of cortical folding.

AB - Convoluted cortical folding and neuronal wiring are 2 prominent attributes of the mammalian brain. However, the macroscale intrinsic relationship between these 2 general cross-species attributes, as well as the underlying principles that sculpt the architecture of the cerebral cortex, remains unclear. Here, we show that the axonal fibers connected to gyri are significantly denser than those connected to sulci. In human, chimpanzee, and macaque brains, a dominant fraction of axonal fibers were found to be connected to the gyri. This finding has been replicated in a range of mammalian brains via diffusion tensor imaging and high-angular resolution diffusion imaging. These results may have shed some lights on fundamental mechanisms for development and organization of the cerebral cortex, suggesting that axonal pushing is a mechanism of cortical folding.

KW - cortical folding

KW - diffusion tensor imaging

KW - shape analysis

UR - http://www.scopus.com/inward/record.url?scp=84869015890&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84869015890&partnerID=8YFLogxK

U2 - 10.1093/cercor/bhr361

DO - 10.1093/cercor/bhr361

M3 - Article

C2 - 22190432

AN - SCOPUS:84869015890

VL - 22

SP - 2831

EP - 2839

JO - Cerebral Cortex

JF - Cerebral Cortex

SN - 1047-3211

IS - 12

ER -