B cells limit repair after ischemic acute kidney injury

Hye Ryoun Jang, Maria Teresa Gandolfo, Gang Jee Ko, Shailesh R. Satpute, Lorraine Racusen, Hamid Rabb

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

There is no established modality to repair kidney damage resulting from ischemia-reperfusion injury (IRI). Early responses to IRI involve lymphocytes, but the role of B cells in tissue repair after IRI is unknown. Here, we examined B cell trafficking into postischemic mouse kidneys and compared the repair response between control (wild-type) and μMT (B cell-deficient) mice with and without adoptive transfer of B cells. B cells infiltrated postischemic kidneys and subsequently activated and differentiated to plasma cells during the repair phase. Plasma cells expressing CD126 increased and B-1 B cells trafficked into postischemic kidneys with distinct kinetics. An increase in B lymphocyte chemoattractant in the kidney preceded B cell trafficking. Postischemic kidneys of μMT mice expressed higher IL-10 and vascular endothelial growth factor and exhibited more tubular proliferation and less tubular atrophy. Adoptive transfer of B cells into μMT mice reduced tubular proliferation and increased tubular atrophy. Treatment with anti-CD126 antibody increased tubular proliferation and reduced tubular atrophy in the late repair phase. These results demonstrate that B cells may limit the repair process after kidney IRI. Targeting B cells could have therapeutic potential to improve repair after IRI.

Original languageEnglish
Pages (from-to)654-665
Number of pages12
JournalJournal of the American Society of Nephrology
Volume21
Issue number4
DOIs
Publication statusPublished - 2010 Apr 1
Externally publishedYes

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Acute Kidney Injury
B-Lymphocytes
Reperfusion Injury
Kidney
Atrophy
Adoptive Transfer
Plasma Cells
Chemotactic Factors
Interleukin-10
Vascular Endothelial Growth Factor A
Anti-Idiotypic Antibodies
Lymphocytes

ASJC Scopus subject areas

  • Nephrology

Cite this

B cells limit repair after ischemic acute kidney injury. / Jang, Hye Ryoun; Gandolfo, Maria Teresa; Ko, Gang Jee; Satpute, Shailesh R.; Racusen, Lorraine; Rabb, Hamid.

In: Journal of the American Society of Nephrology, Vol. 21, No. 4, 01.04.2010, p. 654-665.

Research output: Contribution to journalArticle

Jang, HR, Gandolfo, MT, Ko, GJ, Satpute, SR, Racusen, L & Rabb, H 2010, 'B cells limit repair after ischemic acute kidney injury', Journal of the American Society of Nephrology, vol. 21, no. 4, pp. 654-665. https://doi.org/10.1681/ASN.2009020182
Jang, Hye Ryoun ; Gandolfo, Maria Teresa ; Ko, Gang Jee ; Satpute, Shailesh R. ; Racusen, Lorraine ; Rabb, Hamid. / B cells limit repair after ischemic acute kidney injury. In: Journal of the American Society of Nephrology. 2010 ; Vol. 21, No. 4. pp. 654-665.
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