Backbone resonances assignment of 19 kDa CD1 domain of human mitotic checkpoint serine/threonine-protein kinase, Bub1

Sung Jean Park, Hyun Hwi Kim, Yu Sun Jung, Su Jin Kang, Hae Kap Cheong, Hyun Kyu Song, Bong Jin Lee

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Bub1 is an evolutionarily conserved mitotic checkpoint control protein that is present in diverse organisms including yeast and humans. Bub1 is a serine/threonine protein kinase and is required for recruitment of Mad1, Mad2, Bub3, and CENP-E to kinetochores (Sharp-Baker and Chen in J Cell Biol 153:1239-1250, 2001). The evolutionarily conserved amino acid region in the N-terminus has been called as the CD1 domain. To clarify the action mechanism of Bub1 in controlling check point signals, we initiated an NMR structure determination of the Bub1 CD1 domain. Here, we report the sequence-specific backbone resonance assignments of CD1 domain of human Bub1 (hBub1CD1).

Original languageEnglish
Pages (from-to)109-113
Number of pages5
JournalBiomolecular NMR Assignments
Volume6
Issue number1
DOIs
Publication statusPublished - 2012 Apr 1

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M Phase Cell Cycle Checkpoints
Protein-Serine-Threonine Kinases
Yeast
Nuclear magnetic resonance
Amino Acids
Kinetochores
Proteins
Yeasts

Keywords

  • Bub1
  • Kinetochore
  • Mad3-like
  • NMR
  • Spindle checkpoint

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry

Cite this

Backbone resonances assignment of 19 kDa CD1 domain of human mitotic checkpoint serine/threonine-protein kinase, Bub1. / Park, Sung Jean; Kim, Hyun Hwi; Jung, Yu Sun; Kang, Su Jin; Cheong, Hae Kap; Song, Hyun Kyu; Lee, Bong Jin.

In: Biomolecular NMR Assignments, Vol. 6, No. 1, 01.04.2012, p. 109-113.

Research output: Contribution to journalArticle

Park, Sung Jean ; Kim, Hyun Hwi ; Jung, Yu Sun ; Kang, Su Jin ; Cheong, Hae Kap ; Song, Hyun Kyu ; Lee, Bong Jin. / Backbone resonances assignment of 19 kDa CD1 domain of human mitotic checkpoint serine/threonine-protein kinase, Bub1. In: Biomolecular NMR Assignments. 2012 ; Vol. 6, No. 1. pp. 109-113.
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