Background 18F-FDG uptake in positron emission mammography (PEM)

Correlation with mammographic density and background parenchymal enhancement in breast MRI

Hye Ryoung Koo, Woo Kyung Moon, In Kook Chun, Jae Seon Eo, Joseph Xavier Jeyanth, Jung Min Chang, Nariya Cho, Keon Wook Kang

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We aimed to determine whether background 18F-FDG uptake in positron emission mammography (PEM) was related to mammographic density or background parenchymal enhancement in breast MRI. Methods: We studied a total of 52 patients (mean age, 50.9 years, 26 premenopausal, 26 postmenopausal) with newly diagnosed breast cancer who underwent 18F-FDG PEM (positron emission mammography), conventional mammography and breast MRI. The background mean 18F-FDG uptake value on PEM was obtained by drawing a user-defined region of interest (ROI) in a normal area of the contralateral breast. We reviewed the mammography retrospectively for overall breast density of contralateral breast according to the four-point scale (grade 1-4) of the Breast Imaging Reporting and Data System (BI-RADS) classification. The background parenchymal enhancement of breast MRI was classified as minimal, mild, moderate, or marked. All imaging findings were interpreted by two readers in consensus without knowledge of image findings of other modalities. Results: Multiple linear regression analysis revealed a significant correlation between background 18F-FDG uptake on PEM and mammographic density after adjustment for age and menopausal status (P < 0.01), but not between background 18F-FDG uptake on PEM and background parenchymal enhancement on MRI. Conclusion: Background 18F-FDG uptake on PEM significantly increases as mammographic density increases. Background parenchymal enhancement in breast MRI was not an independent predictor of the background 18F-FDG uptake on PEM unlike mammographic density.

Original languageEnglish
Pages (from-to)1738-1742
Number of pages5
JournalEuropean Journal of Radiology
Volume82
Issue number10
DOIs
Publication statusPublished - 2013 Jan 1

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Fluorodeoxyglucose F18
Mammography
Breast
Electrons
Breast Density
Information Systems
Linear Models
Regression Analysis
Breast Neoplasms

Keywords

  • (BPE)
  • Background parenchymal enhancement
  • Breast mri
  • Mammographic density
  • Pem (positron emission mammography)

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Background 18F-FDG uptake in positron emission mammography (PEM) : Correlation with mammographic density and background parenchymal enhancement in breast MRI. / Koo, Hye Ryoung; Moon, Woo Kyung; Chun, In Kook; Eo, Jae Seon; Jeyanth, Joseph Xavier; Chang, Jung Min; Cho, Nariya; Kang, Keon Wook.

In: European Journal of Radiology, Vol. 82, No. 10, 01.01.2013, p. 1738-1742.

Research output: Contribution to journalArticle

Koo, Hye Ryoung ; Moon, Woo Kyung ; Chun, In Kook ; Eo, Jae Seon ; Jeyanth, Joseph Xavier ; Chang, Jung Min ; Cho, Nariya ; Kang, Keon Wook. / Background 18F-FDG uptake in positron emission mammography (PEM) : Correlation with mammographic density and background parenchymal enhancement in breast MRI. In: European Journal of Radiology. 2013 ; Vol. 82, No. 10. pp. 1738-1742.
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AU - Eo, Jae Seon

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