Abstract
We aimed to determine whether background 18F-FDG uptake in positron emission mammography (PEM) was related to mammographic density or background parenchymal enhancement in breast MRI. Methods: We studied a total of 52 patients (mean age, 50.9 years, 26 premenopausal, 26 postmenopausal) with newly diagnosed breast cancer who underwent 18F-FDG PEM (positron emission mammography), conventional mammography and breast MRI. The background mean 18F-FDG uptake value on PEM was obtained by drawing a user-defined region of interest (ROI) in a normal area of the contralateral breast. We reviewed the mammography retrospectively for overall breast density of contralateral breast according to the four-point scale (grade 1-4) of the Breast Imaging Reporting and Data System (BI-RADS) classification. The background parenchymal enhancement of breast MRI was classified as minimal, mild, moderate, or marked. All imaging findings were interpreted by two readers in consensus without knowledge of image findings of other modalities. Results: Multiple linear regression analysis revealed a significant correlation between background 18F-FDG uptake on PEM and mammographic density after adjustment for age and menopausal status (P < 0.01), but not between background 18F-FDG uptake on PEM and background parenchymal enhancement on MRI. Conclusion: Background 18F-FDG uptake on PEM significantly increases as mammographic density increases. Background parenchymal enhancement in breast MRI was not an independent predictor of the background 18F-FDG uptake on PEM unlike mammographic density.
| Original language | English |
|---|---|
| Pages (from-to) | 1738-1742 |
| Number of pages | 5 |
| Journal | European Journal of Radiology |
| Volume | 82 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 2013 Jan 1 |
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Keywords
- (BPE)
- Background parenchymal enhancement
- Breast mri
- Mammographic density
- Pem (positron emission mammography)
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
Background 18F-FDG uptake in positron emission mammography (PEM) : Correlation with mammographic density and background parenchymal enhancement in breast MRI. / Koo, Hye Ryoung; Moon, Woo Kyung; Chun, In Kook; Eo, Jae Seon; Jeyanth, Joseph Xavier; Chang, Jung Min; Cho, Nariya; Kang, Keon Wook.
In: European Journal of Radiology, Vol. 82, No. 10, 01.01.2013, p. 1738-1742.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Background 18F-FDG uptake in positron emission mammography (PEM)
T2 - Correlation with mammographic density and background parenchymal enhancement in breast MRI
AU - Koo, Hye Ryoung
AU - Moon, Woo Kyung
AU - Chun, In Kook
AU - Eo, Jae Seon
AU - Jeyanth, Joseph Xavier
AU - Chang, Jung Min
AU - Cho, Nariya
AU - Kang, Keon Wook
PY - 2013/1/1
Y1 - 2013/1/1
N2 - We aimed to determine whether background 18F-FDG uptake in positron emission mammography (PEM) was related to mammographic density or background parenchymal enhancement in breast MRI. Methods: We studied a total of 52 patients (mean age, 50.9 years, 26 premenopausal, 26 postmenopausal) with newly diagnosed breast cancer who underwent 18F-FDG PEM (positron emission mammography), conventional mammography and breast MRI. The background mean 18F-FDG uptake value on PEM was obtained by drawing a user-defined region of interest (ROI) in a normal area of the contralateral breast. We reviewed the mammography retrospectively for overall breast density of contralateral breast according to the four-point scale (grade 1-4) of the Breast Imaging Reporting and Data System (BI-RADS) classification. The background parenchymal enhancement of breast MRI was classified as minimal, mild, moderate, or marked. All imaging findings were interpreted by two readers in consensus without knowledge of image findings of other modalities. Results: Multiple linear regression analysis revealed a significant correlation between background 18F-FDG uptake on PEM and mammographic density after adjustment for age and menopausal status (P < 0.01), but not between background 18F-FDG uptake on PEM and background parenchymal enhancement on MRI. Conclusion: Background 18F-FDG uptake on PEM significantly increases as mammographic density increases. Background parenchymal enhancement in breast MRI was not an independent predictor of the background 18F-FDG uptake on PEM unlike mammographic density.
AB - We aimed to determine whether background 18F-FDG uptake in positron emission mammography (PEM) was related to mammographic density or background parenchymal enhancement in breast MRI. Methods: We studied a total of 52 patients (mean age, 50.9 years, 26 premenopausal, 26 postmenopausal) with newly diagnosed breast cancer who underwent 18F-FDG PEM (positron emission mammography), conventional mammography and breast MRI. The background mean 18F-FDG uptake value on PEM was obtained by drawing a user-defined region of interest (ROI) in a normal area of the contralateral breast. We reviewed the mammography retrospectively for overall breast density of contralateral breast according to the four-point scale (grade 1-4) of the Breast Imaging Reporting and Data System (BI-RADS) classification. The background parenchymal enhancement of breast MRI was classified as minimal, mild, moderate, or marked. All imaging findings were interpreted by two readers in consensus without knowledge of image findings of other modalities. Results: Multiple linear regression analysis revealed a significant correlation between background 18F-FDG uptake on PEM and mammographic density after adjustment for age and menopausal status (P < 0.01), but not between background 18F-FDG uptake on PEM and background parenchymal enhancement on MRI. Conclusion: Background 18F-FDG uptake on PEM significantly increases as mammographic density increases. Background parenchymal enhancement in breast MRI was not an independent predictor of the background 18F-FDG uptake on PEM unlike mammographic density.
KW - (BPE)
KW - Background parenchymal enhancement
KW - Breast mri
KW - Mammographic density
KW - Pem (positron emission mammography)
UR - http://www.scopus.com/inward/record.url?scp=84893690983&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84893690983&partnerID=8YFLogxK
U2 - 10.1016/j.ejrad.2013.05.016
DO - 10.1016/j.ejrad.2013.05.016
M3 - Article
VL - 82
SP - 1738
EP - 1742
JO - European Journal of Radiology
JF - European Journal of Radiology
SN - 0720-048X
IS - 10
ER -