Bacteremia due to quinolone-resistant Escherichia coli in a teaching hospital in South Korea

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Quinolone-resistant Escherichia coli (QREC) strains are being isolated with increasing frequency. From 1993 to 1998, 40 cases of QREC bacteremia were observed in a teaching hospital; 25 episodes (63.5%) were community-acquired. The incidence of QREC bacteremia increased steadily, from 6.7% to 24.6% during 5 years, and correlated with the significantly increased use of fluoroquinolones (P = .003, r = 0.98). When the 40 QREC bacteremic patients were compared with 80 patients with bacteremia due to quinolone-susceptible E. coli, prior fluoroquinolone use was the only independent risk factor for QREC bacteremia (P = .001). A high APACHE II score was the only independent risk factor for death. The rate of multidrug resistance of QREC was much higher (60%) than that of quinolone-susceptible isolates (13.8%). Pulsed-field gel electrophoresis patterns of these isolates were diverse. Therefore, the isolates revealed little evidence of clonal spread and may have emerged in direct response to the selective pressure exerted by prior fluoroquinolone use.

Original languageEnglish
Pages (from-to)48-53
Number of pages6
JournalClinical Infectious Diseases
Volume33
Issue number1
DOIs
Publication statusPublished - 2001 Jul 3

Fingerprint

Republic of Korea
Quinolones
Bacteremia
Teaching Hospitals
Escherichia coli
Fluoroquinolones
APACHE
Pulsed Field Gel Electrophoresis
Multiple Drug Resistance
Incidence

ASJC Scopus subject areas

  • Immunology

Cite this

Bacteremia due to quinolone-resistant Escherichia coli in a teaching hospital in South Korea. / Cheong, Hee-Jin; Yoo, C. W.; Sohn, Jang Wook; Kim, Woo Joo; Min, Ja Kim; Park, S. C.

In: Clinical Infectious Diseases, Vol. 33, No. 1, 03.07.2001, p. 48-53.

Research output: Contribution to journalArticle

@article{89caa437582b4c78bc732c771e0cb3c7,
title = "Bacteremia due to quinolone-resistant Escherichia coli in a teaching hospital in South Korea",
abstract = "Quinolone-resistant Escherichia coli (QREC) strains are being isolated with increasing frequency. From 1993 to 1998, 40 cases of QREC bacteremia were observed in a teaching hospital; 25 episodes (63.5{\%}) were community-acquired. The incidence of QREC bacteremia increased steadily, from 6.7{\%} to 24.6{\%} during 5 years, and correlated with the significantly increased use of fluoroquinolones (P = .003, r = 0.98). When the 40 QREC bacteremic patients were compared with 80 patients with bacteremia due to quinolone-susceptible E. coli, prior fluoroquinolone use was the only independent risk factor for QREC bacteremia (P = .001). A high APACHE II score was the only independent risk factor for death. The rate of multidrug resistance of QREC was much higher (60{\%}) than that of quinolone-susceptible isolates (13.8{\%}). Pulsed-field gel electrophoresis patterns of these isolates were diverse. Therefore, the isolates revealed little evidence of clonal spread and may have emerged in direct response to the selective pressure exerted by prior fluoroquinolone use.",
author = "Hee-Jin Cheong and Yoo, {C. W.} and Sohn, {Jang Wook} and Kim, {Woo Joo} and Min, {Ja Kim} and Park, {S. C.}",
year = "2001",
month = "7",
day = "3",
doi = "10.1086/320873",
language = "English",
volume = "33",
pages = "48--53",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "Oxford University Press",
number = "1",

}

TY - JOUR

T1 - Bacteremia due to quinolone-resistant Escherichia coli in a teaching hospital in South Korea

AU - Cheong, Hee-Jin

AU - Yoo, C. W.

AU - Sohn, Jang Wook

AU - Kim, Woo Joo

AU - Min, Ja Kim

AU - Park, S. C.

PY - 2001/7/3

Y1 - 2001/7/3

N2 - Quinolone-resistant Escherichia coli (QREC) strains are being isolated with increasing frequency. From 1993 to 1998, 40 cases of QREC bacteremia were observed in a teaching hospital; 25 episodes (63.5%) were community-acquired. The incidence of QREC bacteremia increased steadily, from 6.7% to 24.6% during 5 years, and correlated with the significantly increased use of fluoroquinolones (P = .003, r = 0.98). When the 40 QREC bacteremic patients were compared with 80 patients with bacteremia due to quinolone-susceptible E. coli, prior fluoroquinolone use was the only independent risk factor for QREC bacteremia (P = .001). A high APACHE II score was the only independent risk factor for death. The rate of multidrug resistance of QREC was much higher (60%) than that of quinolone-susceptible isolates (13.8%). Pulsed-field gel electrophoresis patterns of these isolates were diverse. Therefore, the isolates revealed little evidence of clonal spread and may have emerged in direct response to the selective pressure exerted by prior fluoroquinolone use.

AB - Quinolone-resistant Escherichia coli (QREC) strains are being isolated with increasing frequency. From 1993 to 1998, 40 cases of QREC bacteremia were observed in a teaching hospital; 25 episodes (63.5%) were community-acquired. The incidence of QREC bacteremia increased steadily, from 6.7% to 24.6% during 5 years, and correlated with the significantly increased use of fluoroquinolones (P = .003, r = 0.98). When the 40 QREC bacteremic patients were compared with 80 patients with bacteremia due to quinolone-susceptible E. coli, prior fluoroquinolone use was the only independent risk factor for QREC bacteremia (P = .001). A high APACHE II score was the only independent risk factor for death. The rate of multidrug resistance of QREC was much higher (60%) than that of quinolone-susceptible isolates (13.8%). Pulsed-field gel electrophoresis patterns of these isolates were diverse. Therefore, the isolates revealed little evidence of clonal spread and may have emerged in direct response to the selective pressure exerted by prior fluoroquinolone use.

UR - http://www.scopus.com/inward/record.url?scp=0034987891&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034987891&partnerID=8YFLogxK

U2 - 10.1086/320873

DO - 10.1086/320873

M3 - Article

C2 - 11389494

AN - SCOPUS:0034987891

VL - 33

SP - 48

EP - 53

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

SN - 1058-4838

IS - 1

ER -