Bacterial Mg2+ homeostasis, transport, and virulence

Eduardo A. Groisman, Kerry Hollands, Michelle A. Kriner, Eun-Jin Lee, Sun Yang Park, Mauricio H. Pontes

Research output: Contribution to journalReview article

86 Citations (Scopus)

Abstract

Organisms must maintain physiological levels of Mg2+ because this divalent cation is critical for the stabilization of membranes and ribosomes, for the neutralization of nucleic acids, and as a cofactor in a variety of enzymatic reactions. In this review, we describe the mechanisms that bacteria utilize to sense the levels of Mg2+ both outside and inside the cytoplasm. We examine how bacteria achieve Mg2+ homeostasis by adjusting the expression and activity of Mg2+ transporters and by changing the composition of their cell envelope. We discuss the connections that exist between Mg2+ sensing, Mg2+ transport, and bacterial virulence. Additionally, we explore the logic behind the fact that bacterial genomes encode multiple Mg2+ transporters and distinct sensing systems for cytoplasmic and extracytoplasmic Mg2+. These analyses may be applicable to the homeostatic control of other cations.

Original languageEnglish
Pages (from-to)625-646
Number of pages22
JournalAnnual Review of Genetics
Volume47
DOIs
Publication statusPublished - 2013 Jan 1
Externally publishedYes

Keywords

  • ATP
  • CorA
  • Gene regulation
  • Lipopolysaccharide
  • MgtA
  • MgtB
  • MgtE
  • PhoP/PhoQ

ASJC Scopus subject areas

  • Genetics

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  • Cite this

    Groisman, E. A., Hollands, K., Kriner, M. A., Lee, E-J., Park, S. Y., & Pontes, M. H. (2013). Bacterial Mg2+ homeostasis, transport, and virulence. Annual Review of Genetics, 47, 625-646. https://doi.org/10.1146/annurev-genet-051313-051025