Bacterial Mg2+ homeostasis, transport, and virulence

Eduardo A. Groisman, Kerry Hollands, Michelle A. Kriner, Eun-Jin Lee, Sun Yang Park, Mauricio H. Pontes

Research output: Contribution to journalReview article

73 Citations (Scopus)

Abstract

Organisms must maintain physiological levels of Mg2+ because this divalent cation is critical for the stabilization of membranes and ribosomes, for the neutralization of nucleic acids, and as a cofactor in a variety of enzymatic reactions. In this review, we describe the mechanisms that bacteria utilize to sense the levels of Mg2+ both outside and inside the cytoplasm. We examine how bacteria achieve Mg2+ homeostasis by adjusting the expression and activity of Mg2+ transporters and by changing the composition of their cell envelope. We discuss the connections that exist between Mg2+ sensing, Mg2+ transport, and bacterial virulence. Additionally, we explore the logic behind the fact that bacterial genomes encode multiple Mg2+ transporters and distinct sensing systems for cytoplasmic and extracytoplasmic Mg2+. These analyses may be applicable to the homeostatic control of other cations.

Original languageEnglish
Pages (from-to)625-646
Number of pages22
JournalAnnual Review of Genetics
Volume47
DOIs
Publication statusPublished - 2013 Jan 1
Externally publishedYes

Fingerprint

Virulence
Homeostasis
Bacteria
Bacterial Genomes
Divalent Cations
Ribosomes
Nucleic Acids
Cations
Cytoplasm
Membranes

Keywords

  • ATP
  • CorA
  • Gene regulation
  • Lipopolysaccharide
  • MgtA
  • MgtB
  • MgtE
  • PhoP/PhoQ

ASJC Scopus subject areas

  • Genetics

Cite this

Groisman, E. A., Hollands, K., Kriner, M. A., Lee, E-J., Park, S. Y., & Pontes, M. H. (2013). Bacterial Mg2+ homeostasis, transport, and virulence. Annual Review of Genetics, 47, 625-646. https://doi.org/10.1146/annurev-genet-051313-051025

Bacterial Mg2+ homeostasis, transport, and virulence. / Groisman, Eduardo A.; Hollands, Kerry; Kriner, Michelle A.; Lee, Eun-Jin; Park, Sun Yang; Pontes, Mauricio H.

In: Annual Review of Genetics, Vol. 47, 01.01.2013, p. 625-646.

Research output: Contribution to journalReview article

Groisman, EA, Hollands, K, Kriner, MA, Lee, E-J, Park, SY & Pontes, MH 2013, 'Bacterial Mg2+ homeostasis, transport, and virulence', Annual Review of Genetics, vol. 47, pp. 625-646. https://doi.org/10.1146/annurev-genet-051313-051025
Groisman, Eduardo A. ; Hollands, Kerry ; Kriner, Michelle A. ; Lee, Eun-Jin ; Park, Sun Yang ; Pontes, Mauricio H. / Bacterial Mg2+ homeostasis, transport, and virulence. In: Annual Review of Genetics. 2013 ; Vol. 47. pp. 625-646.
@article{069cbb32255844e38d1ec970c84af16e,
title = "Bacterial Mg2+ homeostasis, transport, and virulence",
abstract = "Organisms must maintain physiological levels of Mg2+ because this divalent cation is critical for the stabilization of membranes and ribosomes, for the neutralization of nucleic acids, and as a cofactor in a variety of enzymatic reactions. In this review, we describe the mechanisms that bacteria utilize to sense the levels of Mg2+ both outside and inside the cytoplasm. We examine how bacteria achieve Mg2+ homeostasis by adjusting the expression and activity of Mg2+ transporters and by changing the composition of their cell envelope. We discuss the connections that exist between Mg2+ sensing, Mg2+ transport, and bacterial virulence. Additionally, we explore the logic behind the fact that bacterial genomes encode multiple Mg2+ transporters and distinct sensing systems for cytoplasmic and extracytoplasmic Mg2+. These analyses may be applicable to the homeostatic control of other cations.",
keywords = "ATP, CorA, Gene regulation, Lipopolysaccharide, MgtA, MgtB, MgtE, PhoP/PhoQ",
author = "Groisman, {Eduardo A.} and Kerry Hollands and Kriner, {Michelle A.} and Eun-Jin Lee and Park, {Sun Yang} and Pontes, {Mauricio H.}",
year = "2013",
month = "1",
day = "1",
doi = "10.1146/annurev-genet-051313-051025",
language = "English",
volume = "47",
pages = "625--646",
journal = "Annual Review of Genetics",
issn = "0066-4197",
publisher = "Annual Reviews Inc.",

}

TY - JOUR

T1 - Bacterial Mg2+ homeostasis, transport, and virulence

AU - Groisman, Eduardo A.

AU - Hollands, Kerry

AU - Kriner, Michelle A.

AU - Lee, Eun-Jin

AU - Park, Sun Yang

AU - Pontes, Mauricio H.

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Organisms must maintain physiological levels of Mg2+ because this divalent cation is critical for the stabilization of membranes and ribosomes, for the neutralization of nucleic acids, and as a cofactor in a variety of enzymatic reactions. In this review, we describe the mechanisms that bacteria utilize to sense the levels of Mg2+ both outside and inside the cytoplasm. We examine how bacteria achieve Mg2+ homeostasis by adjusting the expression and activity of Mg2+ transporters and by changing the composition of their cell envelope. We discuss the connections that exist between Mg2+ sensing, Mg2+ transport, and bacterial virulence. Additionally, we explore the logic behind the fact that bacterial genomes encode multiple Mg2+ transporters and distinct sensing systems for cytoplasmic and extracytoplasmic Mg2+. These analyses may be applicable to the homeostatic control of other cations.

AB - Organisms must maintain physiological levels of Mg2+ because this divalent cation is critical for the stabilization of membranes and ribosomes, for the neutralization of nucleic acids, and as a cofactor in a variety of enzymatic reactions. In this review, we describe the mechanisms that bacteria utilize to sense the levels of Mg2+ both outside and inside the cytoplasm. We examine how bacteria achieve Mg2+ homeostasis by adjusting the expression and activity of Mg2+ transporters and by changing the composition of their cell envelope. We discuss the connections that exist between Mg2+ sensing, Mg2+ transport, and bacterial virulence. Additionally, we explore the logic behind the fact that bacterial genomes encode multiple Mg2+ transporters and distinct sensing systems for cytoplasmic and extracytoplasmic Mg2+. These analyses may be applicable to the homeostatic control of other cations.

KW - ATP

KW - CorA

KW - Gene regulation

KW - Lipopolysaccharide

KW - MgtA

KW - MgtB

KW - MgtE

KW - PhoP/PhoQ

UR - http://www.scopus.com/inward/record.url?scp=84888616330&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84888616330&partnerID=8YFLogxK

U2 - 10.1146/annurev-genet-051313-051025

DO - 10.1146/annurev-genet-051313-051025

M3 - Review article

C2 - 24079267

AN - SCOPUS:84888616330

VL - 47

SP - 625

EP - 646

JO - Annual Review of Genetics

JF - Annual Review of Genetics

SN - 0066-4197

ER -