Abstract
Organisms must maintain physiological levels of Mg2+ because this divalent cation is critical for the stabilization of membranes and ribosomes, for the neutralization of nucleic acids, and as a cofactor in a variety of enzymatic reactions. In this review, we describe the mechanisms that bacteria utilize to sense the levels of Mg2+ both outside and inside the cytoplasm. We examine how bacteria achieve Mg2+ homeostasis by adjusting the expression and activity of Mg2+ transporters and by changing the composition of their cell envelope. We discuss the connections that exist between Mg2+ sensing, Mg2+ transport, and bacterial virulence. Additionally, we explore the logic behind the fact that bacterial genomes encode multiple Mg2+ transporters and distinct sensing systems for cytoplasmic and extracytoplasmic Mg2+. These analyses may be applicable to the homeostatic control of other cations.
| Original language | English |
|---|---|
| Pages (from-to) | 625-646 |
| Number of pages | 22 |
| Journal | Annual Review of Genetics |
| Volume | 47 |
| DOIs | |
| Publication status | Published - 2013 Jan 1 |
| Externally published | Yes |
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Keywords
- ATP
- CorA
- Gene regulation
- Lipopolysaccharide
- MgtA
- MgtB
- MgtE
- PhoP/PhoQ
ASJC Scopus subject areas
- Genetics
Cite this
Bacterial Mg2+ homeostasis, transport, and virulence. / Groisman, Eduardo A.; Hollands, Kerry; Kriner, Michelle A.; Lee, Eun-Jin; Park, Sun Yang; Pontes, Mauricio H.
In: Annual Review of Genetics, Vol. 47, 01.01.2013, p. 625-646.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Bacterial Mg2+ homeostasis, transport, and virulence
AU - Groisman, Eduardo A.
AU - Hollands, Kerry
AU - Kriner, Michelle A.
AU - Lee, Eun-Jin
AU - Park, Sun Yang
AU - Pontes, Mauricio H.
PY - 2013/1/1
Y1 - 2013/1/1
N2 - Organisms must maintain physiological levels of Mg2+ because this divalent cation is critical for the stabilization of membranes and ribosomes, for the neutralization of nucleic acids, and as a cofactor in a variety of enzymatic reactions. In this review, we describe the mechanisms that bacteria utilize to sense the levels of Mg2+ both outside and inside the cytoplasm. We examine how bacteria achieve Mg2+ homeostasis by adjusting the expression and activity of Mg2+ transporters and by changing the composition of their cell envelope. We discuss the connections that exist between Mg2+ sensing, Mg2+ transport, and bacterial virulence. Additionally, we explore the logic behind the fact that bacterial genomes encode multiple Mg2+ transporters and distinct sensing systems for cytoplasmic and extracytoplasmic Mg2+. These analyses may be applicable to the homeostatic control of other cations.
AB - Organisms must maintain physiological levels of Mg2+ because this divalent cation is critical for the stabilization of membranes and ribosomes, for the neutralization of nucleic acids, and as a cofactor in a variety of enzymatic reactions. In this review, we describe the mechanisms that bacteria utilize to sense the levels of Mg2+ both outside and inside the cytoplasm. We examine how bacteria achieve Mg2+ homeostasis by adjusting the expression and activity of Mg2+ transporters and by changing the composition of their cell envelope. We discuss the connections that exist between Mg2+ sensing, Mg2+ transport, and bacterial virulence. Additionally, we explore the logic behind the fact that bacterial genomes encode multiple Mg2+ transporters and distinct sensing systems for cytoplasmic and extracytoplasmic Mg2+. These analyses may be applicable to the homeostatic control of other cations.
KW - ATP
KW - CorA
KW - Gene regulation
KW - Lipopolysaccharide
KW - MgtA
KW - MgtB
KW - MgtE
KW - PhoP/PhoQ
UR - http://www.scopus.com/inward/record.url?scp=84888616330&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84888616330&partnerID=8YFLogxK
U2 - 10.1146/annurev-genet-051313-051025
DO - 10.1146/annurev-genet-051313-051025
M3 - Review article
C2 - 24079267
AN - SCOPUS:84888616330
VL - 47
SP - 625
EP - 646
JO - Annual Review of Genetics
JF - Annual Review of Genetics
SN - 0066-4197
ER -