Basal blood corticosterone level is correlated with susceptibility to chronic restraint stress in mice

Jae Gon Kim, Hye Seung Jung, Ki Joon Kim, Sun Seek Min, Bong June Yoon

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Corticosterone is released in response to stress and manifests as various bodily stress responses in rodents. While corticosterone reflects acute adaptive responses, how the basal steady-state corticosterone level relates to the subsequent stress response is largely unknown. Here, we investigated how basal corticosterone levels can affect the susceptibility to chronic restraint stress in mice. We designed a longitudinal experiment, enabling us to compare the basal corticosterone level and the subsequent response to repeated restraint stress within the same animal. We found that the mice had differential changes in plasma corticosterone levels, which either increased or decreased, with exposure to chronic stress. These differential changes reflected the differential stress susceptibility of the mice, as evaluated by changes in body weight. The extent of the changes in corticosterone level during chronic stress exposure was predicted by the basal corticosterone level. In addition, the behavioral consequence of chronic stress was also correlated with the basal corticosterone level prior to chronic stress experience. These data reveal that the basal steady-state corticosterone level is a predictor of stress susceptibility or resilience to subsequent stress exposures.

Original languageEnglish
Pages (from-to)137-142
Number of pages6
JournalNeuroscience Letters
Volume555
DOIs
Publication statusPublished - 2013 Oct 25

Keywords

  • Anxiety
  • Corticosterone
  • Restraint stress
  • Stress susceptibility

ASJC Scopus subject areas

  • Neuroscience(all)

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