Basal STAT3 activities are negatively correlated with tumor size in papillary thyroid carcinomas

W. G. Kim, H. J. Choi, W. B. Kim, E. Y. Kim, J. H. Yim, T. Y. Kim, G. Gong, S. Y. Kim, Namhyun Chung, Y. K. Shong

Research output: Contribution to journalArticle

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Abstract

Backgrounds: Signal transducer and activators of transcription-3 (STAT3) plays a critical role in promoting survival and cell growth as well as facilitating angiogenesis and metastasis in several cancers. Aim: This investigation focused on evaluation of STAT3 activities in human papillary thyroid cancers (PTC). Methods: STAT3 activities of nuclear extracts of tumor tissue were measured from 35 PTC patients using enzyme-linked immunosorbent assay-based kits. Results: STAT3 activities of PTC tissues were significantly lower than those of surrounding normal thyroid tissues [0.36 (interquartile range 0.24-0.72) vs 0.50 (0.29-1.11) arbitrary units, p<0.01]. We further analyzed the association between STAT3 activity and clinicopathologic factors in PTC tissue. Tumors with size ≥2 cm displayed significantly lower STAT3 activities than those <2 cm [0.25 (0.21-0.37) vs 0.53 (0.37-0.61) arbitrary units, p<0.01]. Notably, tumor size was inversely correlated with STAT3 activities in T1799A BRAF mutation-positive cases (Rs=-0.58, p<0.05), but not mutation-negative cases. Conclusions: STAT3 activities of PTC measured via DNA binding are suppressed in contrast to other human cancers. Tumor size larger than 2 cm is the only clinicopathologic parameter associated with low STAT3 activity. Moreover, tumor size appears inversely correlated with STAT3 activity, specifically in T1799A BRAF mutation-positive cases.

Original languageEnglish
Pages (from-to)413-418
Number of pages6
JournalJournal of Endocrinological Investigation
Volume35
Issue number4
DOIs
Publication statusPublished - 2012 Apr 1

Fingerprint

STAT3 Transcription Factor
Neoplasms
Mutation
Papillary Thyroid cancer
Tissue Extracts
Human Activities
Cell Survival
Thyroid Gland
Enzyme-Linked Immunosorbent Assay
Neoplasm Metastasis

Keywords

  • Mutation
  • Papillary carcinoma
  • Prognosis
  • Proto-oncogene protein B-raf
  • STAT3 transcription factor
  • Thyroid neoplasm

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Kim, W. G., Choi, H. J., Kim, W. B., Kim, E. Y., Yim, J. H., Kim, T. Y., ... Shong, Y. K. (2012). Basal STAT3 activities are negatively correlated with tumor size in papillary thyroid carcinomas. Journal of Endocrinological Investigation, 35(4), 413-418. https://doi.org/10.3275/7907

Basal STAT3 activities are negatively correlated with tumor size in papillary thyroid carcinomas. / Kim, W. G.; Choi, H. J.; Kim, W. B.; Kim, E. Y.; Yim, J. H.; Kim, T. Y.; Gong, G.; Kim, S. Y.; Chung, Namhyun; Shong, Y. K.

In: Journal of Endocrinological Investigation, Vol. 35, No. 4, 01.04.2012, p. 413-418.

Research output: Contribution to journalArticle

Kim, WG, Choi, HJ, Kim, WB, Kim, EY, Yim, JH, Kim, TY, Gong, G, Kim, SY, Chung, N & Shong, YK 2012, 'Basal STAT3 activities are negatively correlated with tumor size in papillary thyroid carcinomas', Journal of Endocrinological Investigation, vol. 35, no. 4, pp. 413-418. https://doi.org/10.3275/7907
Kim, W. G. ; Choi, H. J. ; Kim, W. B. ; Kim, E. Y. ; Yim, J. H. ; Kim, T. Y. ; Gong, G. ; Kim, S. Y. ; Chung, Namhyun ; Shong, Y. K. / Basal STAT3 activities are negatively correlated with tumor size in papillary thyroid carcinomas. In: Journal of Endocrinological Investigation. 2012 ; Vol. 35, No. 4. pp. 413-418.
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abstract = "Backgrounds: Signal transducer and activators of transcription-3 (STAT3) plays a critical role in promoting survival and cell growth as well as facilitating angiogenesis and metastasis in several cancers. Aim: This investigation focused on evaluation of STAT3 activities in human papillary thyroid cancers (PTC). Methods: STAT3 activities of nuclear extracts of tumor tissue were measured from 35 PTC patients using enzyme-linked immunosorbent assay-based kits. Results: STAT3 activities of PTC tissues were significantly lower than those of surrounding normal thyroid tissues [0.36 (interquartile range 0.24-0.72) vs 0.50 (0.29-1.11) arbitrary units, p<0.01]. We further analyzed the association between STAT3 activity and clinicopathologic factors in PTC tissue. Tumors with size ≥2 cm displayed significantly lower STAT3 activities than those <2 cm [0.25 (0.21-0.37) vs 0.53 (0.37-0.61) arbitrary units, p<0.01]. Notably, tumor size was inversely correlated with STAT3 activities in T1799A BRAF mutation-positive cases (Rs=-0.58, p<0.05), but not mutation-negative cases. Conclusions: STAT3 activities of PTC measured via DNA binding are suppressed in contrast to other human cancers. Tumor size larger than 2 cm is the only clinicopathologic parameter associated with low STAT3 activity. Moreover, tumor size appears inversely correlated with STAT3 activity, specifically in T1799A BRAF mutation-positive cases.",
keywords = "Mutation, Papillary carcinoma, Prognosis, Proto-oncogene protein B-raf, STAT3 transcription factor, Thyroid neoplasm",
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AU - Choi, H. J.

AU - Kim, W. B.

AU - Kim, E. Y.

AU - Yim, J. H.

AU - Kim, T. Y.

AU - Gong, G.

AU - Kim, S. Y.

AU - Chung, Namhyun

AU - Shong, Y. K.

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N2 - Backgrounds: Signal transducer and activators of transcription-3 (STAT3) plays a critical role in promoting survival and cell growth as well as facilitating angiogenesis and metastasis in several cancers. Aim: This investigation focused on evaluation of STAT3 activities in human papillary thyroid cancers (PTC). Methods: STAT3 activities of nuclear extracts of tumor tissue were measured from 35 PTC patients using enzyme-linked immunosorbent assay-based kits. Results: STAT3 activities of PTC tissues were significantly lower than those of surrounding normal thyroid tissues [0.36 (interquartile range 0.24-0.72) vs 0.50 (0.29-1.11) arbitrary units, p<0.01]. We further analyzed the association between STAT3 activity and clinicopathologic factors in PTC tissue. Tumors with size ≥2 cm displayed significantly lower STAT3 activities than those <2 cm [0.25 (0.21-0.37) vs 0.53 (0.37-0.61) arbitrary units, p<0.01]. Notably, tumor size was inversely correlated with STAT3 activities in T1799A BRAF mutation-positive cases (Rs=-0.58, p<0.05), but not mutation-negative cases. Conclusions: STAT3 activities of PTC measured via DNA binding are suppressed in contrast to other human cancers. Tumor size larger than 2 cm is the only clinicopathologic parameter associated with low STAT3 activity. Moreover, tumor size appears inversely correlated with STAT3 activity, specifically in T1799A BRAF mutation-positive cases.

AB - Backgrounds: Signal transducer and activators of transcription-3 (STAT3) plays a critical role in promoting survival and cell growth as well as facilitating angiogenesis and metastasis in several cancers. Aim: This investigation focused on evaluation of STAT3 activities in human papillary thyroid cancers (PTC). Methods: STAT3 activities of nuclear extracts of tumor tissue were measured from 35 PTC patients using enzyme-linked immunosorbent assay-based kits. Results: STAT3 activities of PTC tissues were significantly lower than those of surrounding normal thyroid tissues [0.36 (interquartile range 0.24-0.72) vs 0.50 (0.29-1.11) arbitrary units, p<0.01]. We further analyzed the association between STAT3 activity and clinicopathologic factors in PTC tissue. Tumors with size ≥2 cm displayed significantly lower STAT3 activities than those <2 cm [0.25 (0.21-0.37) vs 0.53 (0.37-0.61) arbitrary units, p<0.01]. Notably, tumor size was inversely correlated with STAT3 activities in T1799A BRAF mutation-positive cases (Rs=-0.58, p<0.05), but not mutation-negative cases. Conclusions: STAT3 activities of PTC measured via DNA binding are suppressed in contrast to other human cancers. Tumor size larger than 2 cm is the only clinicopathologic parameter associated with low STAT3 activity. Moreover, tumor size appears inversely correlated with STAT3 activity, specifically in T1799A BRAF mutation-positive cases.

KW - Mutation

KW - Papillary carcinoma

KW - Prognosis

KW - Proto-oncogene protein B-raf

KW - STAT3 transcription factor

KW - Thyroid neoplasm

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