Baseline and change in uric acid concentration over time are associated with incident hypertension in large Korean cohort

Ki Chul Sung, Christopher D. Byrne, Seungho Ryu, Jong Young Lee, Sung Ho Lee, Jang Young Kim, Seong Hwan Kim, Sarah H. Wild, Eliseo Guallar

Research output: Contribution to journalArticle

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Abstract

BACKGROUND It is uncertain whether high-baseline uric acid (UA) or change in UA concentration over time is related to development of incident hypertension. To investigate relationships between: (i) baseline serum UA concentration and (ii) change in UA concentration and incident hypertension. METHODS About 96,606 Korean individuals (with follow-up UA data available for 56,085 people) participating in a health check program was undertaken. Cox regression models were used to estimate adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for incident hypertension according to UA quartiles regarding the lowest UA quartile as the reference, and also according to change in UA concentration comparing individuals with an increase in UA to those with a decrease in UA concentration over time. RESULTS Total follow up time was 8 years (median follow-up 3.3 years; interquartile range, 1.9-5.1). About 10,405 cases of incident hypertension occurred. In the fully adjusted regression models, the HRs (95% CI) for incident hypertension comparing the highest vs. the lowest quartiles of UA were 1.29 (1.19-1.38) in men and 1.24 (1.09-1.42) in women, with statistically significant P for trend for both gender. Additionally, stable or increasing UA concentration over time was associated with increased risk of incident hypertension, particularly in participants with baseline UA concentration ≥median (aHRs 1.14; 95% CI (1.03-1.26) and 1.18; 95% CI (0.98-1.40) in men and women, respectively). CONCLUSIONS High initial UA concentration and increases in UA concentration over time should be considered independent risk factors for hypertension.

Original languageEnglish
Pages (from-to)42-50
Number of pages9
JournalAmerican Journal of Hypertension
Volume30
Issue number1
DOIs
Publication statusPublished - 2017 Jan 1

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Uric Acid
Hypertension
Confidence Intervals
Proportional Hazards Models

Keywords

  • Blood pressure
  • Hypertension
  • Risk
  • Risk factors
  • Uric acid

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Baseline and change in uric acid concentration over time are associated with incident hypertension in large Korean cohort. / Sung, Ki Chul; Byrne, Christopher D.; Ryu, Seungho; Lee, Jong Young; Lee, Sung Ho; Kim, Jang Young; Kim, Seong Hwan; Wild, Sarah H.; Guallar, Eliseo.

In: American Journal of Hypertension, Vol. 30, No. 1, 01.01.2017, p. 42-50.

Research output: Contribution to journalArticle

Sung, Ki Chul ; Byrne, Christopher D. ; Ryu, Seungho ; Lee, Jong Young ; Lee, Sung Ho ; Kim, Jang Young ; Kim, Seong Hwan ; Wild, Sarah H. ; Guallar, Eliseo. / Baseline and change in uric acid concentration over time are associated with incident hypertension in large Korean cohort. In: American Journal of Hypertension. 2017 ; Vol. 30, No. 1. pp. 42-50.
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abstract = "BACKGROUND It is uncertain whether high-baseline uric acid (UA) or change in UA concentration over time is related to development of incident hypertension. To investigate relationships between: (i) baseline serum UA concentration and (ii) change in UA concentration and incident hypertension. METHODS About 96,606 Korean individuals (with follow-up UA data available for 56,085 people) participating in a health check program was undertaken. Cox regression models were used to estimate adjusted hazard ratios (aHRs) and 95{\%} confidence intervals (CIs) for incident hypertension according to UA quartiles regarding the lowest UA quartile as the reference, and also according to change in UA concentration comparing individuals with an increase in UA to those with a decrease in UA concentration over time. RESULTS Total follow up time was 8 years (median follow-up 3.3 years; interquartile range, 1.9-5.1). About 10,405 cases of incident hypertension occurred. In the fully adjusted regression models, the HRs (95{\%} CI) for incident hypertension comparing the highest vs. the lowest quartiles of UA were 1.29 (1.19-1.38) in men and 1.24 (1.09-1.42) in women, with statistically significant P for trend for both gender. Additionally, stable or increasing UA concentration over time was associated with increased risk of incident hypertension, particularly in participants with baseline UA concentration ≥median (aHRs 1.14; 95{\%} CI (1.03-1.26) and 1.18; 95{\%} CI (0.98-1.40) in men and women, respectively). CONCLUSIONS High initial UA concentration and increases in UA concentration over time should be considered independent risk factors for hypertension.",
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AU - Byrne, Christopher D.

AU - Ryu, Seungho

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AU - Lee, Sung Ho

AU - Kim, Jang Young

AU - Kim, Seong Hwan

AU - Wild, Sarah H.

AU - Guallar, Eliseo

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N2 - BACKGROUND It is uncertain whether high-baseline uric acid (UA) or change in UA concentration over time is related to development of incident hypertension. To investigate relationships between: (i) baseline serum UA concentration and (ii) change in UA concentration and incident hypertension. METHODS About 96,606 Korean individuals (with follow-up UA data available for 56,085 people) participating in a health check program was undertaken. Cox regression models were used to estimate adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for incident hypertension according to UA quartiles regarding the lowest UA quartile as the reference, and also according to change in UA concentration comparing individuals with an increase in UA to those with a decrease in UA concentration over time. RESULTS Total follow up time was 8 years (median follow-up 3.3 years; interquartile range, 1.9-5.1). About 10,405 cases of incident hypertension occurred. In the fully adjusted regression models, the HRs (95% CI) for incident hypertension comparing the highest vs. the lowest quartiles of UA were 1.29 (1.19-1.38) in men and 1.24 (1.09-1.42) in women, with statistically significant P for trend for both gender. Additionally, stable or increasing UA concentration over time was associated with increased risk of incident hypertension, particularly in participants with baseline UA concentration ≥median (aHRs 1.14; 95% CI (1.03-1.26) and 1.18; 95% CI (0.98-1.40) in men and women, respectively). CONCLUSIONS High initial UA concentration and increases in UA concentration over time should be considered independent risk factors for hypertension.

AB - BACKGROUND It is uncertain whether high-baseline uric acid (UA) or change in UA concentration over time is related to development of incident hypertension. To investigate relationships between: (i) baseline serum UA concentration and (ii) change in UA concentration and incident hypertension. METHODS About 96,606 Korean individuals (with follow-up UA data available for 56,085 people) participating in a health check program was undertaken. Cox regression models were used to estimate adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for incident hypertension according to UA quartiles regarding the lowest UA quartile as the reference, and also according to change in UA concentration comparing individuals with an increase in UA to those with a decrease in UA concentration over time. RESULTS Total follow up time was 8 years (median follow-up 3.3 years; interquartile range, 1.9-5.1). About 10,405 cases of incident hypertension occurred. In the fully adjusted regression models, the HRs (95% CI) for incident hypertension comparing the highest vs. the lowest quartiles of UA were 1.29 (1.19-1.38) in men and 1.24 (1.09-1.42) in women, with statistically significant P for trend for both gender. Additionally, stable or increasing UA concentration over time was associated with increased risk of incident hypertension, particularly in participants with baseline UA concentration ≥median (aHRs 1.14; 95% CI (1.03-1.26) and 1.18; 95% CI (0.98-1.40) in men and women, respectively). CONCLUSIONS High initial UA concentration and increases in UA concentration over time should be considered independent risk factors for hypertension.

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