BCL6 gene mutations in transitional cell carcinomas

H. Y. Cho, Hong Seok Park, Z. Lin, I. Kim, K. J. Joo, Jun Cheon

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The B-cell lymphoma-6 (BCL6) gene was initially identified at a translocation site observed frequently in diffuse large B-cell lymphomas. In the present study, BCL6 mutations at the 5′ non-coding region in 47 cases of transitional call carcinoma (TCC) were analysed using polymerase chain reaction-single-strand conformation polymorphism. The results were compared with data obtained previously by immunohistochemical staining for the BCL6 protein. Overall, BCL6 mutations were observed in 44.7% of cases. Mutation of the 5′ non-coding region was not correlated with histological grade of the tumour; however, the better the histological grade, the greater the mutation rate of the E1.12 fragment. The BCL6 mutation occurred independently of over-expression of the protein. The BCL6 gene mutation and the protein expression were detectable in a large proportion of TCCs. BCL6 protein over-expression as well as BCL6 gene mutation of the E1.12 fragment may play an important role in the morphological differentiation of TCC.

Original languageEnglish
Pages (from-to)224-230
Number of pages7
JournalJournal of International Medical Research
Volume35
Issue number2
DOIs
Publication statusPublished - 2007 Jan 1

Fingerprint

Proto-Oncogene Proteins c-bcl-6
Transitional Cell Carcinoma
B-Cell Lymphoma
Genes
Cells
Mutation
Polymerase chain reaction
Polymorphism
Conformations
Tumors
Proteins
Carcinoma
Lymphoma, Large B-Cell, Diffuse
Mutation Rate
Staining and Labeling
Polymerase Chain Reaction
Neoplasms

Keywords

  • BCL6
  • Mutation
  • Polymerase chain reaction-single-strand conformation polymorphism
  • Transitional cell carcinoma

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Biochemistry, medical

Cite this

BCL6 gene mutations in transitional cell carcinomas. / Cho, H. Y.; Park, Hong Seok; Lin, Z.; Kim, I.; Joo, K. J.; Cheon, Jun.

In: Journal of International Medical Research, Vol. 35, No. 2, 01.01.2007, p. 224-230.

Research output: Contribution to journalArticle

Cho, H. Y. ; Park, Hong Seok ; Lin, Z. ; Kim, I. ; Joo, K. J. ; Cheon, Jun. / BCL6 gene mutations in transitional cell carcinomas. In: Journal of International Medical Research. 2007 ; Vol. 35, No. 2. pp. 224-230.
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