Abstract
Objective: The aim of this study was to determine whether the brain-derived neurotrophic factor (BDNF) 196 G/A or catechol-O-methyltransferase (COMT) Val158Met polymorphisms is associated with susceptibility to ADHD. Method: We conducted a meta-analysis of the associations between the BDNF 196 G/A and COMT Val158Met polymorphisms and ADHD. Results: Sixteen studies consisting of 3,594 patients with ADHD and 4,040 controls were included in this meta-analysis. Our results showed no association between ADHD and the BDNF 196A allele in all participants (odds ratio [OR] = 0.958, 95% confidence interval [CI] = [0.800, 1.146], p =.638), European or Asian population. Meta-analysis indicated no association between ADHD and the COMT G allele in all study participants (OR = 1.078, 95% CI = [0.962, 1.207], p =.196), European or Asian population. Conclusion: This meta-analysis showed a lack of association between the BDNF 196 G/A and COMT Val158Met polymorphisms and ADHD.
| Original language | English |
|---|---|
| Pages (from-to) | 872-877 |
| Number of pages | 6 |
| Journal | Journal of Attention Disorders |
| Volume | 22 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2018 Jul 1 |
Keywords
- ADHD
- BDNF
- COMT
- meta-analysis
- polymorphism
ASJC Scopus subject areas
- Developmental and Educational Psychology
- Clinical Psychology