BDNF 196 G/A and COMT Val158Met Polymorphisms and Susceptibility to ADHD: A Meta-Analysis

Young Ho Lee, Gwan Gyu Song

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Objective: The aim of this study was to determine whether the brain-derived neurotrophic factor (BDNF) 196 G/A or catechol-O-methyltransferase (COMT) Val158Met polymorphisms is associated with susceptibility to ADHD. Method: We conducted a meta-analysis of the associations between the BDNF 196 G/A and COMT Val158Met polymorphisms and ADHD. Results: Sixteen studies consisting of 3,594 patients with ADHD and 4,040 controls were included in this meta-analysis. Our results showed no association between ADHD and the BDNF 196A allele in all participants (odds ratio [OR] = 0.958, 95% confidence interval [CI] = [0.800, 1.146], p =.638), European or Asian population. Meta-analysis indicated no association between ADHD and the COMT G allele in all study participants (OR = 1.078, 95% CI = [0.962, 1.207], p =.196), European or Asian population. Conclusion: This meta-analysis showed a lack of association between the BDNF 196 G/A and COMT Val158Met polymorphisms and ADHD.

Original languageEnglish
Pages (from-to)872-877
Number of pages6
JournalJournal of Attention Disorders
Volume22
Issue number9
DOIs
Publication statusPublished - 2018 Jul 1

Keywords

  • ADHD
  • BDNF
  • COMT
  • meta-analysis
  • polymorphism

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Clinical Psychology

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