Bee venom promotes hair growth in association with inhibiting 5α-reductase expression

Seeun Park, Sedef Erdogan, Dahyun Hwang, Seonwook Hwang, Eun Hye Han, Young Hee Lim

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Alopecia is an important issue that can occur in people of all ages. Recent studies show that bee venom can be used to treat certain diseases including rheumatoid arthritis, neuralgia, and multiple sclerosis. In this study, we investigated the preventive effect of bee venom on alopecia, which was measured by applying bee venom (0.001, 0.005, 0.01%) or minoxidil (2%) as a positive control to the dorsal skin of female C57BL/6 mice for 19 d. Growth factors responsible for hair growth were analyzed by quantitative real-time PCR and Western blot analysis using mice skins and human dermal papilla cells (hDPCs). Bee venom promoted hair growth and inhibited transition from the anagen to catagen phase. In both anagen phase mice and dexamethasone-induced catagen phase mice, hair growth was increased dose dependently compared with controls. Bee venom inhibited the expression of SRD5A2, which encodes a type II 5α-reductase that plays a major role in the conversion of testosterone into dihydrotestosterone. Moreover, bee venom stimulated proliferation of hDPCs and several growth factors (insulin-like growth factor 1 receptor (IGF-1R), vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF)2 and 7) in bee venom-treated hDPCs dose dependently compared with the control group. In conclusion, bee venom is a potentially potent 5α-reductase inhibitor and hair growth promoter.

Original languageEnglish
Pages (from-to)1060-1068
Number of pages9
JournalBiological and Pharmaceutical Bulletin
Volume39
Issue number6
DOIs
Publication statusPublished - 2016 Jun 1

Fingerprint

Bee Venoms
Hair
Oxidoreductases
Growth
Skin
Alopecia
Intercellular Signaling Peptides and Proteins
Fibroblast Growth Factor 7
Minoxidil
Somatomedin Receptors
Growth Inhibitors
Dihydrotestosterone
Neuralgia
Fibroblast Growth Factor 2
Inbred C57BL Mouse
Dexamethasone
Vascular Endothelial Growth Factor A
Multiple Sclerosis
Testosterone
Real-Time Polymerase Chain Reaction

Keywords

  • 5α-reductase
  • Alopecia
  • Bee venom
  • Dihydrotestosterone
  • Human dermal papilla cell

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

Cite this

Bee venom promotes hair growth in association with inhibiting 5α-reductase expression. / Park, Seeun; Erdogan, Sedef; Hwang, Dahyun; Hwang, Seonwook; Han, Eun Hye; Lim, Young Hee.

In: Biological and Pharmaceutical Bulletin, Vol. 39, No. 6, 01.06.2016, p. 1060-1068.

Research output: Contribution to journalArticle

Park, Seeun ; Erdogan, Sedef ; Hwang, Dahyun ; Hwang, Seonwook ; Han, Eun Hye ; Lim, Young Hee. / Bee venom promotes hair growth in association with inhibiting 5α-reductase expression. In: Biological and Pharmaceutical Bulletin. 2016 ; Vol. 39, No. 6. pp. 1060-1068.
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