Beneficial effects of Codonopsis lanceolata extract on systolic blood pressure levels in prehypertensive adults: A double-blind, randomized controlled trial

You Kyoung Shin, Yu Shan Hsieh, A. Young Han, Kwang Won Lee, Geun Hee Seol

Research output: Contribution to journalArticle


Codonopsis lanceolata (CL) extract was shown to have antihypertensive effects in hypertensive rats. This randomized controlled trial was designed to investigate the ability of CL extract to prevent hypertension (HTN) in prehypertensive subjects. Eighty subjects aged 19–60 years with a systolic blood pressure (BP) of 120–139 mmHg and a diastolic BP of 80–89 mmHg were recruited over 3 months. Subjects were randomized 1:1 to a CL group and a placebo (PL) group and administered CL extract and starch, respectively, for 6 weeks. (BP) was measured and blood sampled at baseline and at the end of the trial. Relative to baseline, systolic BP was significantly decreased, and catalase activity was significantly increased following CL treatment in both the elevated systolic BP and stage 1 HTN subgroups. In the elevated systolic BP subgroup, serum nitrite concentration relative to baseline was significantly increased in CL compared to PL treated subjects (p =.038). In subjects with stage 1 HTN, high sensitivity C-reactive protein (p =.020) and malondialdehyde (p =.039) showed significantly greater reductions from baseline in the CL than in the PL group. In summary, CL was effective in preventing endothelial dysfunction, inflammation, and lipid peroxidation in prehypertensive subjects, with these effects differing according to baseline systolic BP levels.

Original languageEnglish
JournalPhytotherapy Research
Publication statusAccepted/In press - 2019 Jan 1



  • Codonopsis lanceolata
  • high sensitivity C-reactive protein
  • malondialdehyde
  • nitric oxide
  • prehypertension
  • prevention

ASJC Scopus subject areas

  • Pharmacology

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