Benefit of implantable cardioverter-defibrillator therapy after generator replacement in patients with Brugada syndrome

Ju Youn Kim, Sung Hwan Kim, Sung Su Kim, Ki Hong Lee, Hyung Wook Park, Jeong Gwan Cho, Jae Sun Uhm, Boyoung Joung, Hui Nam Pak, Moon Hyoung Lee, Seung Jung Park, Young Keun On, June Soo Kim, Hong Euy Lim, Jaemin Shim, Jongil Choi, Sang Weon Park, Young Hoon Kim, Woo Seok Lee, Jun KimGi Byoun Nam, Kee Joon Choi, You Ho Kim, Yong Seog Oh, Man Young Lee, Tai Ho Rho

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: An implantable cardioverter-defibrillator (ICD) is the only proven effective therapeutic strategy for patients with Brugada syndrome (BS). However, it is controversial whether the device should be replaced even in patients who had never experienced appropriate ICD therapy until the time of generator replacement. Methods and results: This was a nationwide, multicenter retrospective study that enrolled patients who were diagnosed with BS and had an ICD implantation between January 1998 and April 2014. Appropriate ICD therapies administered for ventricular tachyarrhythmia were evaluated during follow-up. A total of 117 patients (age 43 ± 12 years, male 115 [98.3%]) were enrolled, and the mean follow-up duration was 6.0 ± 4.1 years. Thirty-seven (31.6%) patients had experienced appropriate ICD therapy during follow-up. Of all patients, 46 underwent replacement of the device. After the first generator replacement, the incidence of appropriate ICD therapy remained as high as 65.2% in patients who previously experienced appropriate ICD therapy before generator replacement. In 30 patients who did not experience any cardiac events until the first generator change, two (8.7%) had an episode of appropriate ICD therapy afterwards. Conclusions: No episode of ICD therapy before generator replacement could not guarantee a safe clinical course. ICD generator replacement should be considered even in patients without ICD therapy before.

Original languageEnglish
Pages (from-to)340-344
Number of pages5
JournalInternational Journal of Cardiology
Volume187
Issue number1
DOIs
Publication statusPublished - 2015 May 6

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Brugada Syndrome
Implantable Defibrillators
Therapeutics
Equipment and Supplies
Tachycardia
Multicenter Studies
Retrospective Studies

Keywords

  • Brugada syndrome
  • Implantable cardioverter-defibrillator
  • Replacement

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Benefit of implantable cardioverter-defibrillator therapy after generator replacement in patients with Brugada syndrome. / Kim, Ju Youn; Kim, Sung Hwan; Kim, Sung Su; Lee, Ki Hong; Park, Hyung Wook; Cho, Jeong Gwan; Uhm, Jae Sun; Joung, Boyoung; Pak, Hui Nam; Lee, Moon Hyoung; Park, Seung Jung; On, Young Keun; Kim, June Soo; Lim, Hong Euy; Shim, Jaemin; Choi, Jongil; Park, Sang Weon; Kim, Young Hoon; Lee, Woo Seok; Kim, Jun; Nam, Gi Byoun; Choi, Kee Joon; Kim, You Ho; Oh, Yong Seog; Lee, Man Young; Rho, Tai Ho.

In: International Journal of Cardiology, Vol. 187, No. 1, 06.05.2015, p. 340-344.

Research output: Contribution to journalArticle

Kim, JY, Kim, SH, Kim, SS, Lee, KH, Park, HW, Cho, JG, Uhm, JS, Joung, B, Pak, HN, Lee, MH, Park, SJ, On, YK, Kim, JS, Lim, HE, Shim, J, Choi, J, Park, SW, Kim, YH, Lee, WS, Kim, J, Nam, GB, Choi, KJ, Kim, YH, Oh, YS, Lee, MY & Rho, TH 2015, 'Benefit of implantable cardioverter-defibrillator therapy after generator replacement in patients with Brugada syndrome', International Journal of Cardiology, vol. 187, no. 1, pp. 340-344. https://doi.org/10.1016/j.ijcard.2015.03.262
Kim, Ju Youn ; Kim, Sung Hwan ; Kim, Sung Su ; Lee, Ki Hong ; Park, Hyung Wook ; Cho, Jeong Gwan ; Uhm, Jae Sun ; Joung, Boyoung ; Pak, Hui Nam ; Lee, Moon Hyoung ; Park, Seung Jung ; On, Young Keun ; Kim, June Soo ; Lim, Hong Euy ; Shim, Jaemin ; Choi, Jongil ; Park, Sang Weon ; Kim, Young Hoon ; Lee, Woo Seok ; Kim, Jun ; Nam, Gi Byoun ; Choi, Kee Joon ; Kim, You Ho ; Oh, Yong Seog ; Lee, Man Young ; Rho, Tai Ho. / Benefit of implantable cardioverter-defibrillator therapy after generator replacement in patients with Brugada syndrome. In: International Journal of Cardiology. 2015 ; Vol. 187, No. 1. pp. 340-344.
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abstract = "Background: An implantable cardioverter-defibrillator (ICD) is the only proven effective therapeutic strategy for patients with Brugada syndrome (BS). However, it is controversial whether the device should be replaced even in patients who had never experienced appropriate ICD therapy until the time of generator replacement. Methods and results: This was a nationwide, multicenter retrospective study that enrolled patients who were diagnosed with BS and had an ICD implantation between January 1998 and April 2014. Appropriate ICD therapies administered for ventricular tachyarrhythmia were evaluated during follow-up. A total of 117 patients (age 43 ± 12 years, male 115 [98.3{\%}]) were enrolled, and the mean follow-up duration was 6.0 ± 4.1 years. Thirty-seven (31.6{\%}) patients had experienced appropriate ICD therapy during follow-up. Of all patients, 46 underwent replacement of the device. After the first generator replacement, the incidence of appropriate ICD therapy remained as high as 65.2{\%} in patients who previously experienced appropriate ICD therapy before generator replacement. In 30 patients who did not experience any cardiac events until the first generator change, two (8.7{\%}) had an episode of appropriate ICD therapy afterwards. Conclusions: No episode of ICD therapy before generator replacement could not guarantee a safe clinical course. ICD generator replacement should be considered even in patients without ICD therapy before.",
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T1 - Benefit of implantable cardioverter-defibrillator therapy after generator replacement in patients with Brugada syndrome

AU - Kim, Ju Youn

AU - Kim, Sung Hwan

AU - Kim, Sung Su

AU - Lee, Ki Hong

AU - Park, Hyung Wook

AU - Cho, Jeong Gwan

AU - Uhm, Jae Sun

AU - Joung, Boyoung

AU - Pak, Hui Nam

AU - Lee, Moon Hyoung

AU - Park, Seung Jung

AU - On, Young Keun

AU - Kim, June Soo

AU - Lim, Hong Euy

AU - Shim, Jaemin

AU - Choi, Jongil

AU - Park, Sang Weon

AU - Kim, Young Hoon

AU - Lee, Woo Seok

AU - Kim, Jun

AU - Nam, Gi Byoun

AU - Choi, Kee Joon

AU - Kim, You Ho

AU - Oh, Yong Seog

AU - Lee, Man Young

AU - Rho, Tai Ho

PY - 2015/5/6

Y1 - 2015/5/6

N2 - Background: An implantable cardioverter-defibrillator (ICD) is the only proven effective therapeutic strategy for patients with Brugada syndrome (BS). However, it is controversial whether the device should be replaced even in patients who had never experienced appropriate ICD therapy until the time of generator replacement. Methods and results: This was a nationwide, multicenter retrospective study that enrolled patients who were diagnosed with BS and had an ICD implantation between January 1998 and April 2014. Appropriate ICD therapies administered for ventricular tachyarrhythmia were evaluated during follow-up. A total of 117 patients (age 43 ± 12 years, male 115 [98.3%]) were enrolled, and the mean follow-up duration was 6.0 ± 4.1 years. Thirty-seven (31.6%) patients had experienced appropriate ICD therapy during follow-up. Of all patients, 46 underwent replacement of the device. After the first generator replacement, the incidence of appropriate ICD therapy remained as high as 65.2% in patients who previously experienced appropriate ICD therapy before generator replacement. In 30 patients who did not experience any cardiac events until the first generator change, two (8.7%) had an episode of appropriate ICD therapy afterwards. Conclusions: No episode of ICD therapy before generator replacement could not guarantee a safe clinical course. ICD generator replacement should be considered even in patients without ICD therapy before.

AB - Background: An implantable cardioverter-defibrillator (ICD) is the only proven effective therapeutic strategy for patients with Brugada syndrome (BS). However, it is controversial whether the device should be replaced even in patients who had never experienced appropriate ICD therapy until the time of generator replacement. Methods and results: This was a nationwide, multicenter retrospective study that enrolled patients who were diagnosed with BS and had an ICD implantation between January 1998 and April 2014. Appropriate ICD therapies administered for ventricular tachyarrhythmia were evaluated during follow-up. A total of 117 patients (age 43 ± 12 years, male 115 [98.3%]) were enrolled, and the mean follow-up duration was 6.0 ± 4.1 years. Thirty-seven (31.6%) patients had experienced appropriate ICD therapy during follow-up. Of all patients, 46 underwent replacement of the device. After the first generator replacement, the incidence of appropriate ICD therapy remained as high as 65.2% in patients who previously experienced appropriate ICD therapy before generator replacement. In 30 patients who did not experience any cardiac events until the first generator change, two (8.7%) had an episode of appropriate ICD therapy afterwards. Conclusions: No episode of ICD therapy before generator replacement could not guarantee a safe clinical course. ICD generator replacement should be considered even in patients without ICD therapy before.

KW - Brugada syndrome

KW - Implantable cardioverter-defibrillator

KW - Replacement

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