Benexate hydrochloride betadex modulates nitric oxide synthesis and cytokine expression in gastric ulcers

Jae Min Lee, Ji Youn Lim, Yoonjin Kim, Ye Ji Kim, Hyuk Soon Choi, Eun-Sun Kim, Bora Keum, Yeon Seok Seo, Yoon Tae Jeen, Hong Sik Lee, Soon-Ho Um, Chang Duck Kim, Ho Sang Ryu, Dong Geun Sul, Junghwa Hong, Hoon-Jai Chun

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5 Citations (Scopus)

Abstract

The present study investigated benexate hydrochloride betadex (BHB)-mediated ulcer healing, and changes to microcirculation modulated through nitric oxide synthase (NOS) and anti-inflammatory activity. A rat model of gastric mucosal injury was established through injection of a 60% acetic acid solution into the stomach. Following ulcer induction, the rats were administered BHB orally for 5 days at doses of 0, 100, 300 or 1,000 mg/kg. The highest dose of BHB was also administered with or without L-NG-nitroarginine methyl ester (L-NAME). The area of gastric ulcers was determined by planimetry, and expression of cyclooxygenases (COX), cytokines and NOS in stomach tissues were measured using western blotting. Compared with the control group, gastric ulcer size was significantly decreased in the 1,000 mg/kg BHB-treated group (P

Original languageEnglish
Pages (from-to)573-580
Number of pages8
JournalExperimental and Therapeutic Medicine
Volume12
Issue number2
DOIs
Publication statusPublished - 2016 Aug 1

Fingerprint

Stomach Ulcer
Nitric Oxide
Cytokines
Stomach
Nitric Oxide Synthase
Ulcer
NG-Nitroarginine Methyl Ester
Microcirculation
Prostaglandin-Endoperoxide Synthases
Acetic Acid
Anti-Inflammatory Agents
Western Blotting
Control Groups
Injections
betadex
benexate
Wounds and Injuries

Keywords

  • Benexate hydrochloride betadex
  • Cytokine
  • Nitric oxide
  • Stomach
  • Ulcer

ASJC Scopus subject areas

  • Medicine(all)
  • Cancer Research
  • Immunology and Microbiology (miscellaneous)

Cite this

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abstract = "The present study investigated benexate hydrochloride betadex (BHB)-mediated ulcer healing, and changes to microcirculation modulated through nitric oxide synthase (NOS) and anti-inflammatory activity. A rat model of gastric mucosal injury was established through injection of a 60{\%} acetic acid solution into the stomach. Following ulcer induction, the rats were administered BHB orally for 5 days at doses of 0, 100, 300 or 1,000 mg/kg. The highest dose of BHB was also administered with or without L-NG-nitroarginine methyl ester (L-NAME). The area of gastric ulcers was determined by planimetry, and expression of cyclooxygenases (COX), cytokines and NOS in stomach tissues were measured using western blotting. Compared with the control group, gastric ulcer size was significantly decreased in the 1,000 mg/kg BHB-treated group (P",
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AU - Choi, Hyuk Soon

AU - Kim, Eun-Sun

AU - Keum, Bora

AU - Seo, Yeon Seok

AU - Jeen, Yoon Tae

AU - Lee, Hong Sik

AU - Um, Soon-Ho

AU - Kim, Chang Duck

AU - Ryu, Ho Sang

AU - Sul, Dong Geun

AU - Hong, Junghwa

AU - Chun, Hoon-Jai

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