Benidipine has effects similar to losartan on the central blood pressure and arterial stiffness in mild to moderate essential hypertension

Sang Hyun Ihm, Hui Kyung Jeon, Shung Chull Chae, Do-Sun Lim, Kee Sik Kim, Dong Ju Choi, Jong Won Ha, Dong Soo Kim, Kye Hun Kim, Myeong Chan Cho, Sang Hong Baek

Research output: Contribution to journalArticle

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Abstract

Background Central blood pressure (BP) is pathophysiologically more important than peripheral BP for the pathogenesis of cardiovascular disease. Arterial stiffness is also a good predictor of cardiovascular morbidity and mortality. The effects of benidipine, a unique dual L-/T-type calcium channel blocker, on central BP have not been reported. This study aimed to compare the effect of benidipine and losartan on the central BP and arterial stiffness in mild to moderate essential hypertensives. Methods This 24 weeks, multi-center, open label, randomized, active drug comparative, parallel group study was designed as a non-inferiority study. The eligible patients (n=200) were randomly assigned to receive benidipine (n=101) or losartan (n=99). Radial artery applanation tonometry and pulse wave analysis were used to measure the central BP, pulse wave velocity (PWV) and augmentation index (AIx). We also measured the metabolic and inflammatory markers. Results After 24 weeks, the central BP decreased significantly from baseline by (16.8±14.0/10.5±9.2) mmHg (1 mmHg =0.133 kPa) (systolic/diastolic BP; P <0.001) in benidipine group and (18.9±14.7/12.1±10.2) mmHg (P <0.001) in losartan group respectively. Both benidipine and losartan groups significantly lowered peripheral BP (P <0.001) and AIx (P <0.05), but there were no significant differences between the two groups. The mean aortic, brachial and femoral PWV did not change in both groups after 24-week treatment. There were no significant changes of the blood metabolic and inflammatory biomarkers in each group. Conclusion Benidipine is as effective as losartan in lowering the central and peripheral BP, and improving arterial stiffness.

Original languageEnglish
Pages (from-to)2021-2028
Number of pages8
JournalChinese Medical Journal
Volume126
Issue number11
DOIs
Publication statusPublished - 2013 Jun 1

Fingerprint

Vascular Stiffness
Losartan
Blood Pressure
Pulse Wave Analysis
T-Type Calcium Channels
Essential Hypertension
benidipine
L-Type Calcium Channels
Radial Artery
Manometry
Calcium Channel Blockers
Thigh
Arm
Cardiovascular Diseases
Biomarkers
Morbidity

Keywords

  • Arteries
  • Calcium channel blocker
  • Central blood pressure
  • Hypertension
  • Stiffness

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Benidipine has effects similar to losartan on the central blood pressure and arterial stiffness in mild to moderate essential hypertension. / Ihm, Sang Hyun; Jeon, Hui Kyung; Chae, Shung Chull; Lim, Do-Sun; Kim, Kee Sik; Choi, Dong Ju; Ha, Jong Won; Kim, Dong Soo; Kim, Kye Hun; Cho, Myeong Chan; Baek, Sang Hong.

In: Chinese Medical Journal, Vol. 126, No. 11, 01.06.2013, p. 2021-2028.

Research output: Contribution to journalArticle

Ihm, Sang Hyun ; Jeon, Hui Kyung ; Chae, Shung Chull ; Lim, Do-Sun ; Kim, Kee Sik ; Choi, Dong Ju ; Ha, Jong Won ; Kim, Dong Soo ; Kim, Kye Hun ; Cho, Myeong Chan ; Baek, Sang Hong. / Benidipine has effects similar to losartan on the central blood pressure and arterial stiffness in mild to moderate essential hypertension. In: Chinese Medical Journal. 2013 ; Vol. 126, No. 11. pp. 2021-2028.
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abstract = "Background Central blood pressure (BP) is pathophysiologically more important than peripheral BP for the pathogenesis of cardiovascular disease. Arterial stiffness is also a good predictor of cardiovascular morbidity and mortality. The effects of benidipine, a unique dual L-/T-type calcium channel blocker, on central BP have not been reported. This study aimed to compare the effect of benidipine and losartan on the central BP and arterial stiffness in mild to moderate essential hypertensives. Methods This 24 weeks, multi-center, open label, randomized, active drug comparative, parallel group study was designed as a non-inferiority study. The eligible patients (n=200) were randomly assigned to receive benidipine (n=101) or losartan (n=99). Radial artery applanation tonometry and pulse wave analysis were used to measure the central BP, pulse wave velocity (PWV) and augmentation index (AIx). We also measured the metabolic and inflammatory markers. Results After 24 weeks, the central BP decreased significantly from baseline by (16.8±14.0/10.5±9.2) mmHg (1 mmHg =0.133 kPa) (systolic/diastolic BP; P <0.001) in benidipine group and (18.9±14.7/12.1±10.2) mmHg (P <0.001) in losartan group respectively. Both benidipine and losartan groups significantly lowered peripheral BP (P <0.001) and AIx (P <0.05), but there were no significant differences between the two groups. The mean aortic, brachial and femoral PWV did not change in both groups after 24-week treatment. There were no significant changes of the blood metabolic and inflammatory biomarkers in each group. Conclusion Benidipine is as effective as losartan in lowering the central and peripheral BP, and improving arterial stiffness.",
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AU - Ihm, Sang Hyun

AU - Jeon, Hui Kyung

AU - Chae, Shung Chull

AU - Lim, Do-Sun

AU - Kim, Kee Sik

AU - Choi, Dong Ju

AU - Ha, Jong Won

AU - Kim, Dong Soo

AU - Kim, Kye Hun

AU - Cho, Myeong Chan

AU - Baek, Sang Hong

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N2 - Background Central blood pressure (BP) is pathophysiologically more important than peripheral BP for the pathogenesis of cardiovascular disease. Arterial stiffness is also a good predictor of cardiovascular morbidity and mortality. The effects of benidipine, a unique dual L-/T-type calcium channel blocker, on central BP have not been reported. This study aimed to compare the effect of benidipine and losartan on the central BP and arterial stiffness in mild to moderate essential hypertensives. Methods This 24 weeks, multi-center, open label, randomized, active drug comparative, parallel group study was designed as a non-inferiority study. The eligible patients (n=200) were randomly assigned to receive benidipine (n=101) or losartan (n=99). Radial artery applanation tonometry and pulse wave analysis were used to measure the central BP, pulse wave velocity (PWV) and augmentation index (AIx). We also measured the metabolic and inflammatory markers. Results After 24 weeks, the central BP decreased significantly from baseline by (16.8±14.0/10.5±9.2) mmHg (1 mmHg =0.133 kPa) (systolic/diastolic BP; P <0.001) in benidipine group and (18.9±14.7/12.1±10.2) mmHg (P <0.001) in losartan group respectively. Both benidipine and losartan groups significantly lowered peripheral BP (P <0.001) and AIx (P <0.05), but there were no significant differences between the two groups. The mean aortic, brachial and femoral PWV did not change in both groups after 24-week treatment. There were no significant changes of the blood metabolic and inflammatory biomarkers in each group. Conclusion Benidipine is as effective as losartan in lowering the central and peripheral BP, and improving arterial stiffness.

AB - Background Central blood pressure (BP) is pathophysiologically more important than peripheral BP for the pathogenesis of cardiovascular disease. Arterial stiffness is also a good predictor of cardiovascular morbidity and mortality. The effects of benidipine, a unique dual L-/T-type calcium channel blocker, on central BP have not been reported. This study aimed to compare the effect of benidipine and losartan on the central BP and arterial stiffness in mild to moderate essential hypertensives. Methods This 24 weeks, multi-center, open label, randomized, active drug comparative, parallel group study was designed as a non-inferiority study. The eligible patients (n=200) were randomly assigned to receive benidipine (n=101) or losartan (n=99). Radial artery applanation tonometry and pulse wave analysis were used to measure the central BP, pulse wave velocity (PWV) and augmentation index (AIx). We also measured the metabolic and inflammatory markers. Results After 24 weeks, the central BP decreased significantly from baseline by (16.8±14.0/10.5±9.2) mmHg (1 mmHg =0.133 kPa) (systolic/diastolic BP; P <0.001) in benidipine group and (18.9±14.7/12.1±10.2) mmHg (P <0.001) in losartan group respectively. Both benidipine and losartan groups significantly lowered peripheral BP (P <0.001) and AIx (P <0.05), but there were no significant differences between the two groups. The mean aortic, brachial and femoral PWV did not change in both groups after 24-week treatment. There were no significant changes of the blood metabolic and inflammatory biomarkers in each group. Conclusion Benidipine is as effective as losartan in lowering the central and peripheral BP, and improving arterial stiffness.

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KW - Stiffness

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