Bidirectional control of spike timing by GABAA receptor-mediated inhibition during theta oscillation in CA1 pyramidal neurons

Jeehyun Kwag, Ole Paulsen

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Precisely controlled spike times relative to θ-frequency network oscillations play an important role in hippocampal memory processing. Here we study how inhibitory synaptic input during θ oscillation contributes to the control of spike timing. Using whole-cell patch-clamp recordings from CA1 pyramidal cells in vitro with dynamic clamp to simulate θ-frequency oscillation (5 Hz), we show that γ-aminobutyric acid-A (GABAA) receptor-mediated inhibitory postsynaptic potentials (IPSPs) can not only delay but also advance the postsynaptic spike depending on the timing of the inhibition relative to the oscillation. Spike time advancement with IPSP was abolished by the h-channel blocker ZD7288 (10 μM), suggesting that IPSPs can interact with intrinsic membrane conductances to yield bidirectional control of spike timing.

Original languageEnglish
Pages (from-to)1209-1213
Number of pages5
JournalNeuroReport
Volume20
Issue number13
DOIs
Publication statusPublished - 2009 Aug 1
Externally publishedYes

Fingerprint

Inhibitory Postsynaptic Potentials
Pyramidal Cells
GABA-A Receptors
Aminobutyrates
Membranes
Inhibition (Psychology)

Keywords

  • CA1 pyramidal neuron
  • Gamma-aminobutyric acid-A receptor
  • Hippocampus
  • Inhibition
  • Rat
  • Spike timing
  • Theta oscillation

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Bidirectional control of spike timing by GABAA receptor-mediated inhibition during theta oscillation in CA1 pyramidal neurons. / Kwag, Jeehyun; Paulsen, Ole.

In: NeuroReport, Vol. 20, No. 13, 01.08.2009, p. 1209-1213.

Research output: Contribution to journalArticle

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