Bilateral effects of unilateral subthalamic nucleus deep brain stimulation in advanced Parkinson's disease

Sun Ju Chung, Sang R. Jeon, Sung Reul Kim, Young H. Sung, Myoung C. Lee

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

To investigate the bilateral effects of unilateral subthalamic nucleus deep brain stimulation (STN-DBS), we prospectively studied 9 consecutive advanced Parkinson's disease (PD) patients (2 men and 7 women) who underwent unilateral STN-DBS. Patients were evaluated preoperatively and at 3 and 6 months postoperatively with and without dopaminergic medications ('on' and 'off' medication, respectively). Postoperatively, patients were assessed with and without stimulation. We found that, when compared with baseline, the 'off' medication scores of the Unified Parkinson's Disease Rating Scale motor part (UPDRS III) and activities of daily living (UPDRS II) were improved by 37% (p = 0.028) and 50% (p = 0.046) at 6 months after surgery, respectively. Stimulation while 'off' medication improved the total UPDRS score by 42% (p = 0.028) at 6 months. At 6 months after surgery, the subscore of UPDRS III of body parts contralateral to the DBS implantation had improved by 48% (p = 0.028), and the ipsilateral subscore of UPDRS III and the axial subscore of UPDRS III had improved by 20% (p = 0.027) and 39% (p = 0.028), respectively. Daily dosage of levodopa was reduced by 15% at 6 months. No patient exhibited permanent side effects. These findings indicate that unilateral STN-DBS may be a reasonable surgical procedure for selected PD patients who have markedly asymmetric parkinsonism.

Original languageEnglish
Pages (from-to)127-132
Number of pages6
JournalEuropean Neurology
Volume56
Issue number2
DOIs
Publication statusPublished - 2006 Oct 1
Externally publishedYes

Fingerprint

Subthalamic Nucleus
Deep Brain Stimulation
Parkinson Disease
Parkinsonian Disorders
Levodopa
Activities of Daily Living
Human Body

Keywords

  • Deep brain stimulation
  • Parkinson's disease
  • Subthalamic nucleus
  • Unified Parkinson's Disease Rating Scale

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Bilateral effects of unilateral subthalamic nucleus deep brain stimulation in advanced Parkinson's disease. / Chung, Sun Ju; Jeon, Sang R.; Kim, Sung Reul; Sung, Young H.; Lee, Myoung C.

In: European Neurology, Vol. 56, No. 2, 01.10.2006, p. 127-132.

Research output: Contribution to journalArticle

Chung, Sun Ju ; Jeon, Sang R. ; Kim, Sung Reul ; Sung, Young H. ; Lee, Myoung C. / Bilateral effects of unilateral subthalamic nucleus deep brain stimulation in advanced Parkinson's disease. In: European Neurology. 2006 ; Vol. 56, No. 2. pp. 127-132.
@article{20abf12535ba48d8ab10f4b3e5d8cc2e,
title = "Bilateral effects of unilateral subthalamic nucleus deep brain stimulation in advanced Parkinson's disease",
abstract = "To investigate the bilateral effects of unilateral subthalamic nucleus deep brain stimulation (STN-DBS), we prospectively studied 9 consecutive advanced Parkinson's disease (PD) patients (2 men and 7 women) who underwent unilateral STN-DBS. Patients were evaluated preoperatively and at 3 and 6 months postoperatively with and without dopaminergic medications ('on' and 'off' medication, respectively). Postoperatively, patients were assessed with and without stimulation. We found that, when compared with baseline, the 'off' medication scores of the Unified Parkinson's Disease Rating Scale motor part (UPDRS III) and activities of daily living (UPDRS II) were improved by 37{\%} (p = 0.028) and 50{\%} (p = 0.046) at 6 months after surgery, respectively. Stimulation while 'off' medication improved the total UPDRS score by 42{\%} (p = 0.028) at 6 months. At 6 months after surgery, the subscore of UPDRS III of body parts contralateral to the DBS implantation had improved by 48{\%} (p = 0.028), and the ipsilateral subscore of UPDRS III and the axial subscore of UPDRS III had improved by 20{\%} (p = 0.027) and 39{\%} (p = 0.028), respectively. Daily dosage of levodopa was reduced by 15{\%} at 6 months. No patient exhibited permanent side effects. These findings indicate that unilateral STN-DBS may be a reasonable surgical procedure for selected PD patients who have markedly asymmetric parkinsonism.",
keywords = "Deep brain stimulation, Parkinson's disease, Subthalamic nucleus, Unified Parkinson's Disease Rating Scale",
author = "Chung, {Sun Ju} and Jeon, {Sang R.} and Kim, {Sung Reul} and Sung, {Young H.} and Lee, {Myoung C.}",
year = "2006",
month = "10",
day = "1",
doi = "10.1159/000095704",
language = "English",
volume = "56",
pages = "127--132",
journal = "European Neurology",
issn = "0014-3022",
publisher = "S. Karger AG",
number = "2",

}

TY - JOUR

T1 - Bilateral effects of unilateral subthalamic nucleus deep brain stimulation in advanced Parkinson's disease

AU - Chung, Sun Ju

AU - Jeon, Sang R.

AU - Kim, Sung Reul

AU - Sung, Young H.

AU - Lee, Myoung C.

PY - 2006/10/1

Y1 - 2006/10/1

N2 - To investigate the bilateral effects of unilateral subthalamic nucleus deep brain stimulation (STN-DBS), we prospectively studied 9 consecutive advanced Parkinson's disease (PD) patients (2 men and 7 women) who underwent unilateral STN-DBS. Patients were evaluated preoperatively and at 3 and 6 months postoperatively with and without dopaminergic medications ('on' and 'off' medication, respectively). Postoperatively, patients were assessed with and without stimulation. We found that, when compared with baseline, the 'off' medication scores of the Unified Parkinson's Disease Rating Scale motor part (UPDRS III) and activities of daily living (UPDRS II) were improved by 37% (p = 0.028) and 50% (p = 0.046) at 6 months after surgery, respectively. Stimulation while 'off' medication improved the total UPDRS score by 42% (p = 0.028) at 6 months. At 6 months after surgery, the subscore of UPDRS III of body parts contralateral to the DBS implantation had improved by 48% (p = 0.028), and the ipsilateral subscore of UPDRS III and the axial subscore of UPDRS III had improved by 20% (p = 0.027) and 39% (p = 0.028), respectively. Daily dosage of levodopa was reduced by 15% at 6 months. No patient exhibited permanent side effects. These findings indicate that unilateral STN-DBS may be a reasonable surgical procedure for selected PD patients who have markedly asymmetric parkinsonism.

AB - To investigate the bilateral effects of unilateral subthalamic nucleus deep brain stimulation (STN-DBS), we prospectively studied 9 consecutive advanced Parkinson's disease (PD) patients (2 men and 7 women) who underwent unilateral STN-DBS. Patients were evaluated preoperatively and at 3 and 6 months postoperatively with and without dopaminergic medications ('on' and 'off' medication, respectively). Postoperatively, patients were assessed with and without stimulation. We found that, when compared with baseline, the 'off' medication scores of the Unified Parkinson's Disease Rating Scale motor part (UPDRS III) and activities of daily living (UPDRS II) were improved by 37% (p = 0.028) and 50% (p = 0.046) at 6 months after surgery, respectively. Stimulation while 'off' medication improved the total UPDRS score by 42% (p = 0.028) at 6 months. At 6 months after surgery, the subscore of UPDRS III of body parts contralateral to the DBS implantation had improved by 48% (p = 0.028), and the ipsilateral subscore of UPDRS III and the axial subscore of UPDRS III had improved by 20% (p = 0.027) and 39% (p = 0.028), respectively. Daily dosage of levodopa was reduced by 15% at 6 months. No patient exhibited permanent side effects. These findings indicate that unilateral STN-DBS may be a reasonable surgical procedure for selected PD patients who have markedly asymmetric parkinsonism.

KW - Deep brain stimulation

KW - Parkinson's disease

KW - Subthalamic nucleus

KW - Unified Parkinson's Disease Rating Scale

UR - http://www.scopus.com/inward/record.url?scp=33749335617&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33749335617&partnerID=8YFLogxK

U2 - 10.1159/000095704

DO - 10.1159/000095704

M3 - Article

C2 - 16960454

AN - SCOPUS:33749335617

VL - 56

SP - 127

EP - 132

JO - European Neurology

JF - European Neurology

SN - 0014-3022

IS - 2

ER -