Bimodal neural probe for highly co-localized chemical and electrical monitoring of neural activities in vivo

Uikyu Chae, Hyogeun Shin, Nakwon Choi, Mi Jung Ji, Hyun Mee Park, Soo Hyun Lee, Jiwan Woo, Yakdol Cho, Kanghwan Kim, Seulkee Yang, Min Ho Nam, Hyun Yong Yu, Il Joo Cho

Research output: Contribution to journalArticlepeer-review

Abstract

Investigation of the chemical and electrical signals of cells in vivo is critical for studying functional connectivity and brain diseases. Most previous studies have observed either the electrical signals or the chemical signals of cells because recording electrical signals and neurochemicals are done by fundamentally different methods. Herein, we present a bimodal MEMS neural probe that is monolithically integrated with an array of microelectrodes for recording electrical activity, microfluidic channels for sampling extracellular fluid, and a microfluidic interface chip for multiple drug delivery and sample isolation from the localized region at the cellular level. In this work, we successfully demonstrated the functionality of our probe by monitoring and modulating bimodal (electrical and chemical) neural activities through the delivery of chemicals in a co-localized brain region in vivo. We expect our bimodal probe to provide opportunities for a variety of in-depth studies of brain functions as well as for the investigation of neural circuits related to brain diseases.

Original languageEnglish
Article number113473
JournalBiosensors and Bioelectronics
Volume191
DOIs
Publication statusPublished - 2021 Nov 1

Keywords

  • Bimodal neural activity
  • Neural probe
  • Neuromodulation
  • Neurotransmitter
  • Sampling probe

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • Biomedical Engineering
  • Electrochemistry

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