Binary Drug Reinforced First Small-Molecule-Based Prodrug for Synergistic Anticancer Effects

Paramesh Jangili, Miae Won, Seo Jin Kim, Jieun Chun, Inseob Shim, Chulhun Kang, Wen Xiu Ren, Jong Seung Kim

Research output: Contribution to journalArticle

Abstract

We developed a small-molecule-based binary drug delivery system (BDDS) with two anticancer drugs, SN-38 and 5′-DFUR. The drug release from the prodrug BDDS can be achieved upon its reaction with intracellular H2O2, overexpressed in cancer cells. The efficacy of BDDS was demonstrated by a comparative study along with that of a single drug conjugate (SDDS), bearing SN-38 alone.

Original languageEnglish
Pages (from-to)3532-3539
Number of pages8
JournalACS Applied Bio Materials
Volume2
Issue number8
DOIs
Publication statusPublished - 2019 Aug 19

Fingerprint

irinotecan
Prodrugs
Drug Delivery Systems
Molecules
Bearings (structural)
Pharmaceutical Preparations
Cells
Neoplasms

Keywords

  • 5′-DFUR
  • binary drug
  • COX-2
  • SN-38
  • synergistic effect

ASJC Scopus subject areas

  • Biomaterials
  • Chemistry(all)
  • Biomedical Engineering
  • Biochemistry, medical

Cite this

Binary Drug Reinforced First Small-Molecule-Based Prodrug for Synergistic Anticancer Effects. / Jangili, Paramesh; Won, Miae; Kim, Seo Jin; Chun, Jieun; Shim, Inseob; Kang, Chulhun; Ren, Wen Xiu; Kim, Jong Seung.

In: ACS Applied Bio Materials, Vol. 2, No. 8, 19.08.2019, p. 3532-3539.

Research output: Contribution to journalArticle

Jangili, Paramesh ; Won, Miae ; Kim, Seo Jin ; Chun, Jieun ; Shim, Inseob ; Kang, Chulhun ; Ren, Wen Xiu ; Kim, Jong Seung. / Binary Drug Reinforced First Small-Molecule-Based Prodrug for Synergistic Anticancer Effects. In: ACS Applied Bio Materials. 2019 ; Vol. 2, No. 8. pp. 3532-3539.
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