@article{08e77cc875ff40639381ac32cf4dbf17,
title = "Binary Drug Reinforced First Small-Molecule-Based Prodrug for Synergistic Anticancer Effects",
abstract = "We developed a small-molecule-based binary drug delivery system (BDDS) with two anticancer drugs, SN-38 and 5′-DFUR. The drug release from the prodrug BDDS can be achieved upon its reaction with intracellular H2O2, overexpressed in cancer cells. The efficacy of BDDS was demonstrated by a comparative study along with that of a single drug conjugate (SDDS), bearing SN-38 alone.",
keywords = "5′-DFUR, COX-2, SN-38, binary drug, synergistic effect",
author = "Paramesh Jangili and Miae Won and Kim, {Seo Jin} and Jieun Chun and Inseob Shim and Chulhun Kang and Ren, {Wen Xiu} and Kim, {Jong Seung}",
note = "Funding Information: This work was supported by SERB, India (ECR/2015/000035), the programs of the Korean National Research Foundation (NRF) (2018R1A3B1052702, J.S.K.; 2017R1A2A2A05069805, C.K.; 2017R1D1A1B03030062, M.W.), the Korea University Grant (2018–2019), The Open Project Program of Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province (W.X.R.), and the Basic Science Research Program through the NRF funded by the Ministry of Education (no. 2013R1A1A2062997, W.X.R.). Publisher Copyright: {\textcopyright} 2019 American Chemical Society.",
year = "2019",
month = aug,
day = "19",
doi = "10.1021/acsabm.9b00418",
language = "English",
volume = "2",
pages = "3532--3539",
journal = "ACS Applied Bio Materials",
issn = "2576-6422",
publisher = "American Chemical Society",
number = "8",
}
