Binary Drug Reinforced First Small-Molecule-Based Prodrug for Synergistic Anticancer Effects

Paramesh Jangili, Miae Won, Seo Jin Kim, Jieun Chun, Inseob Shim, Chulhun Kang, Wen Xiu Ren, Jong Seung Kim

Research output: Contribution to journalArticle


We developed a small-molecule-based binary drug delivery system (BDDS) with two anticancer drugs, SN-38 and 5′-DFUR. The drug release from the prodrug BDDS can be achieved upon its reaction with intracellular H2O2, overexpressed in cancer cells. The efficacy of BDDS was demonstrated by a comparative study along with that of a single drug conjugate (SDDS), bearing SN-38 alone.

Original languageEnglish
Pages (from-to)3532-3539
Number of pages8
JournalACS Applied Bio Materials
Issue number8
Publication statusPublished - 2019 Aug 19



  • 5′-DFUR
  • binary drug
  • COX-2
  • SN-38
  • synergistic effect

ASJC Scopus subject areas

  • Biomaterials
  • Chemistry(all)
  • Biomedical Engineering
  • Biochemistry, medical

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