Bioactive constituents of the stem bark of Mitrephora glabra

Chen Li, Dongho Lee, Tyler N. Graf, Sharnelle S. Phifer, Yuka Nakanishi, Soedarsono Riswan, Fransisca M. Setyowati, Achmad M. Saribi, Djaja D. Soejarto, Norman R. Farnsworth, Joseph O. Falkinham, David J. Kroll, A. Douglas Kinghorn, Mansukh C. Wani, Nicholas H. Oberlies

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Abstract

Bioactivity-guided fractionation of the stem bark of Mitrephora glabra yielded nine compounds, comprising three entkaurenoids (1-3), five polyacetylenic acids/esters (4-8), and one aporphine alkaloid, liriodenine (9). The structures of the six new compounds (1-3, 5, 7, and 8) were determined by spectroscopic data interpretation. All compounds were evaluated for their inhibitory activities against a panel of cancer cell lines and a battery of microorganisms.

Original languageEnglish
Pages (from-to)1949-1953
Number of pages5
JournalJournal of Natural Products
Volume72
Issue number11
DOIs
Publication statusPublished - 2009 Nov 30

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ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Molecular Medicine
  • Organic Chemistry
  • Analytical Chemistry
  • Pharmaceutical Science
  • Pharmacology
  • Drug Discovery

Cite this

Li, C., Lee, D., Graf, T. N., Phifer, S. S., Nakanishi, Y., Riswan, S., Setyowati, F. M., Saribi, A. M., Soejarto, D. D., Farnsworth, N. R., Falkinham, J. O., Kroll, D. J., Kinghorn, A. D., Wani, M. C., & Oberlies, N. H. (2009). Bioactive constituents of the stem bark of Mitrephora glabra. Journal of Natural Products, 72(11), 1949-1953. https://doi.org/10.1021/np900572g