Bioactive constituents of the stem bark of Mitrephora glabra

Chen Li, Dongho Lee, Tyler N. Graf, Sharnelle S. Phifer, Yuka Nakanishi, Soedarsono Riswan, Fransisca M. Setyowati, Achmad M. Saribi, Djaja D. Soejarto, Norman R. Farnsworth, Joseph O. Falkinham, David J. Kroll, A. Douglas Kinghorn, Mansukh C. Wani, Nicholas H. Oberlies

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Bioactivity-guided fractionation of the stem bark of Mitrephora glabra yielded nine compounds, comprising three entkaurenoids (1-3), five polyacetylenic acids/esters (4-8), and one aporphine alkaloid, liriodenine (9). The structures of the six new compounds (1-3, 5, 7, and 8) were determined by spectroscopic data interpretation. All compounds were evaluated for their inhibitory activities against a panel of cancer cell lines and a battery of microorganisms.

Original languageEnglish
Pages (from-to)1949-1953
Number of pages5
JournalJournal of Natural Products
Volume72
Issue number11
DOIs
Publication statusPublished - 2009 Nov 30

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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    Li, C., Lee, D., Graf, T. N., Phifer, S. S., Nakanishi, Y., Riswan, S., Setyowati, F. M., Saribi, A. M., Soejarto, D. D., Farnsworth, N. R., Falkinham, J. O., Kroll, D. J., Kinghorn, A. D., Wani, M. C., & Oberlies, N. H. (2009). Bioactive constituents of the stem bark of Mitrephora glabra. Journal of Natural Products, 72(11), 1949-1953. https://doi.org/10.1021/np900572g