Bioactive constituents of the stem bark of Mitrephora glabra

Chen Li; Dongho Lee; Tyler N. Graf; Sharnelle S. Phifer; Yuka Nakanishi; Soedarsono Riswan; Fransisca M. Setyowati; Achmad M. Saribi; Djaja D. Soejarto; Norman R. Farnsworth; Joseph O. Falkinham; David J. Kroll; A. Douglas Kinghorn; Mansukh C. Wani; Nicholas H. Oberlies

doi:10.1021/np900572g

Bioactive constituents of the stem bark of Mitrephora glabra

Chen Li, Dongho Lee, Tyler N. Graf, Sharnelle S. Phifer, Yuka Nakanishi, Soedarsono Riswan, Fransisca M. Setyowati, Achmad M. Saribi, Djaja D. Soejarto, Norman R. Farnsworth, Joseph O. Falkinham, David J. Kroll, A. Douglas Kinghorn, Mansukh C. Wani, Nicholas H. Oberlies

Department of Biosystems and Biotechnology

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Abstract

Bioactivity-guided fractionation of the stem bark of Mitrephora glabra yielded nine compounds, comprising three entkaurenoids (1-3), five polyacetylenic acids/esters (4-8), and one aporphine alkaloid, liriodenine (9). The structures of the six new compounds (1-3, 5, 7, and 8) were determined by spectroscopic data interpretation. All compounds were evaluated for their inhibitory activities against a panel of cancer cell lines and a battery of microorganisms.

Original language	English
Pages (from-to)	1949-1953
Number of pages	5
Journal	Journal of Natural Products
Volume	72
Issue number	11
DOIs	https://doi.org/10.1021/np900572g
Publication status	Published - 2009 Nov 30

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/np900572g

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Li, C., Lee, D., Graf, T. N., Phifer, S. S., Nakanishi, Y., Riswan, S., Setyowati, F. M., Saribi, A. M., Soejarto, D. D., Farnsworth, N. R., Falkinham, J. O., Kroll, D. J., Kinghorn, A. D., Wani, M. C., & Oberlies, N. H. (2009). Bioactive constituents of the stem bark of Mitrephora glabra. Journal of Natural Products, 72(11), 1949-1953. https://doi.org/10.1021/np900572g

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title = "Bioactive constituents of the stem bark of Mitrephora glabra",

abstract = "Bioactivity-guided fractionation of the stem bark of Mitrephora glabra yielded nine compounds, comprising three entkaurenoids (1-3), five polyacetylenic acids/esters (4-8), and one aporphine alkaloid, liriodenine (9). The structures of the six new compounds (1-3, 5, 7, and 8) were determined by spectroscopic data interpretation. All compounds were evaluated for their inhibitory activities against a panel of cancer cell lines and a battery of microorganisms.",

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AU - Li, Chen

AU - Lee, Dongho

AU - Graf, Tyler N.

AU - Phifer, Sharnelle S.

AU - Nakanishi, Yuka

AU - Riswan, Soedarsono

AU - Setyowati, Fransisca M.

AU - Saribi, Achmad M.

AU - Soejarto, Djaja D.

AU - Farnsworth, Norman R.

AU - Falkinham, Joseph O.

AU - Kroll, David J.

AU - Kinghorn, A. Douglas

AU - Wani, Mansukh C.

AU - Oberlies, Nicholas H.

PY - 2009/11/30

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AB - Bioactivity-guided fractionation of the stem bark of Mitrephora glabra yielded nine compounds, comprising three entkaurenoids (1-3), five polyacetylenic acids/esters (4-8), and one aporphine alkaloid, liriodenine (9). The structures of the six new compounds (1-3, 5, 7, and 8) were determined by spectroscopic data interpretation. All compounds were evaluated for their inhibitory activities against a panel of cancer cell lines and a battery of microorganisms.

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Bioactive constituents of the stem bark of Mitrephora glabra

Abstract

ASJC Scopus subject areas

UN SDGs

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