Bioactive cyclic dipeptides from a marine sponge-associated bacterium, Psychrobacter sp.

Huayue Li; Byung Cheol Lee; Tae Sung Kim; Kyung Sook Bae; Jongki Hong; Sang Ho Choi; Baoquan Bao; Jee Hyung Jung

doi:10.4062/biomolther.2008.16.4.356

Bioactive cyclic dipeptides from a marine sponge-associated bacterium, Psychrobacter sp.

Huayue Li, Byung Cheol Lee, Tae Sung Kim, Kyung Sook Bae, Jongki Hong, Sang Ho Choi, Baoquan Bao, Jee Hyung Jung

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

A bacterial strain with good antibacterial activities against Staphylococus aureus and Escherichia coli was isolated from a marine sponge Stelleta sp., and it was identified as a Psychrobacter sp. by comparative 16S rDNA sequence analysis. In our search for bioactive secondary metabolites from this psychrophillic and halotolerent bacterium, sixteen cyclic dipeptides (1-16) were isolated and their structures were identified on the basis of NMR analysis. In the test of the compounds for the protective effect against Vibrio vulnificus-induced cytotoxicity in human intestinal epithelial cells, cyclo-(L-Pro-L-Phe) (5) exhibited significant protective effect. Compounds 2, 6, and 11, which contain D-amino acid, were first isolated from bacteria.

Original language	English
Pages (from-to)	356-363
Number of pages	8
Journal	Biomolecules and Therapeutics
Volume	16
Issue number	4
DOIs	https://doi.org/10.4062/biomolther.2008.16.4.356
Publication status	Published - 2008 Dec

Keywords

Cyclic dipeptide
D-proline
Psychrobacter sp.
Sponge-associated
Vibrio vulnificus-induced cytotoxicity

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Pharmacology
Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4062/biomolther.2008.16.4.356

Cite this

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title = "Bioactive cyclic dipeptides from a marine sponge-associated bacterium, Psychrobacter sp.",

abstract = "A bacterial strain with good antibacterial activities against Staphylococus aureus and Escherichia coli was isolated from a marine sponge Stelleta sp., and it was identified as a Psychrobacter sp. by comparative 16S rDNA sequence analysis. In our search for bioactive secondary metabolites from this psychrophillic and halotolerent bacterium, sixteen cyclic dipeptides (1-16) were isolated and their structures were identified on the basis of NMR analysis. In the test of the compounds for the protective effect against Vibrio vulnificus-induced cytotoxicity in human intestinal epithelial cells, cyclo-(L-Pro-L-Phe) (5) exhibited significant protective effect. Compounds 2, 6, and 11, which contain D-amino acid, were first isolated from bacteria.",

keywords = "Cyclic dipeptide, D-proline, Psychrobacter sp., Sponge-associated, Vibrio vulnificus-induced cytotoxicity",

author = "Huayue Li and Lee, {Byung Cheol} and Kim, {Tae Sung} and Bae, {Kyung Sook} and Jongki Hong and Choi, {Sang Ho} and Baoquan Bao and Jung, {Jee Hyung}",

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AU - Li, Huayue

AU - Lee, Byung Cheol

AU - Kim, Tae Sung

AU - Bae, Kyung Sook

AU - Hong, Jongki

AU - Choi, Sang Ho

AU - Bao, Baoquan

AU - Jung, Jee Hyung

PY - 2008/12

Y1 - 2008/12

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AB - A bacterial strain with good antibacterial activities against Staphylococus aureus and Escherichia coli was isolated from a marine sponge Stelleta sp., and it was identified as a Psychrobacter sp. by comparative 16S rDNA sequence analysis. In our search for bioactive secondary metabolites from this psychrophillic and halotolerent bacterium, sixteen cyclic dipeptides (1-16) were isolated and their structures were identified on the basis of NMR analysis. In the test of the compounds for the protective effect against Vibrio vulnificus-induced cytotoxicity in human intestinal epithelial cells, cyclo-(L-Pro-L-Phe) (5) exhibited significant protective effect. Compounds 2, 6, and 11, which contain D-amino acid, were first isolated from bacteria.

KW - Cyclic dipeptide

KW - D-proline

KW - Psychrobacter sp.

KW - Sponge-associated

KW - Vibrio vulnificus-induced cytotoxicity

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DO - 10.4062/biomolther.2008.16.4.356

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AN - SCOPUS:68149178893

SN - 1976-9148

VL - 16

SP - 356

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JO - Biomolecules and Therapeutics

JF - Biomolecules and Therapeutics

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ER -

Bioactive cyclic dipeptides from a marine sponge-associated bacterium, Psychrobacter sp.

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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