Bioactive cyclic dipeptides from a marine sponge-associated bacterium, Psychrobacter sp.

Huayue Li, Byung Cheol Lee, Tae Sung Kim, Kyung Sook Bae, Jongki Hong, Sang Ho Choi, Baoquan Bao, Jee Hyung Jung

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

A bacterial strain with good antibacterial activities against Staphylococus aureus and Escherichia coli was isolated from a marine sponge Stelleta sp., and it was identified as a Psychrobacter sp. by comparative 16S rDNA sequence analysis. In our search for bioactive secondary metabolites from this psychrophillic and halotolerent bacterium, sixteen cyclic dipeptides (1-16) were isolated and their structures were identified on the basis of NMR analysis. In the test of the compounds for the protective effect against Vibrio vulnificus-induced cytotoxicity in human intestinal epithelial cells, cyclo-(L-Pro-L-Phe) (5) exhibited significant protective effect. Compounds 2, 6, and 11, which contain D-amino acid, were first isolated from bacteria.

Original languageEnglish
Pages (from-to)356-363
Number of pages8
JournalBiomolecules and Therapeutics
Volume16
Issue number4
DOIs
Publication statusPublished - 2008 Dec 1

Fingerprint

Psychrobacter
Dipeptides
Porifera
Bacteria
Vibrio vulnificus
Cytotoxicity
Metabolites
Ribosomal DNA
Escherichia coli
Sequence Analysis
Epithelial Cells
Nuclear magnetic resonance
Amino Acids

Keywords

  • Cyclic dipeptide
  • D-proline
  • Psychrobacter sp.
  • Sponge-associated
  • Vibrio vulnificus-induced cytotoxicity

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Drug Discovery
  • Pharmacology

Cite this

Bioactive cyclic dipeptides from a marine sponge-associated bacterium, Psychrobacter sp. / Li, Huayue; Lee, Byung Cheol; Kim, Tae Sung; Bae, Kyung Sook; Hong, Jongki; Choi, Sang Ho; Bao, Baoquan; Jung, Jee Hyung.

In: Biomolecules and Therapeutics, Vol. 16, No. 4, 01.12.2008, p. 356-363.

Research output: Contribution to journalArticle

Li, Huayue ; Lee, Byung Cheol ; Kim, Tae Sung ; Bae, Kyung Sook ; Hong, Jongki ; Choi, Sang Ho ; Bao, Baoquan ; Jung, Jee Hyung. / Bioactive cyclic dipeptides from a marine sponge-associated bacterium, Psychrobacter sp. In: Biomolecules and Therapeutics. 2008 ; Vol. 16, No. 4. pp. 356-363.
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