Bioactive cyclic dipeptides from a marine sponge-associated bacterium, Psychrobacter sp.

Huayue Li, Byung Cheol Lee, Tae Sung Kim, Kyung Sook Bae, Jongki Hong, Sang Ho Choi, Baoquan Bao, Jee Hyung Jung

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

A bacterial strain with good antibacterial activities against Staphylococus aureus and Escherichia coli was isolated from a marine sponge Stelleta sp., and it was identified as a Psychrobacter sp. by comparative 16S rDNA sequence analysis. In our search for bioactive secondary metabolites from this psychrophillic and halotolerent bacterium, sixteen cyclic dipeptides (1-16) were isolated and their structures were identified on the basis of NMR analysis. In the test of the compounds for the protective effect against Vibrio vulnificus-induced cytotoxicity in human intestinal epithelial cells, cyclo-(L-Pro-L-Phe) (5) exhibited significant protective effect. Compounds 2, 6, and 11, which contain D-amino acid, were first isolated from bacteria.

Original languageEnglish
Pages (from-to)356-363
Number of pages8
JournalBiomolecules and Therapeutics
Volume16
Issue number4
DOIs
Publication statusPublished - 2008 Dec

Keywords

  • Cyclic dipeptide
  • D-proline
  • Psychrobacter sp.
  • Sponge-associated
  • Vibrio vulnificus-induced cytotoxicity

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

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