Bioactive Diterpenoids from the Stems of Euphorbia antiquorum

Yue Liang, Lijun An, Zhaoyu Shi, Xuke Zhang, Chunfeng Xie, Muhetaer Tuerhong, Zhaohui Song, Yasushi Ohizumi, Dongho Lee, Ling Shuai, Jing Xu, Yuanqiang Guo

Research output: Contribution to journalArticle

Abstract

A total of 18 diterpenoids, including 10 new analogues (1-10), were isolated from Euphorbia antiquorum. The structures were characterized by spectroscopic techniques, and circular dichroism data analysis was adopted to confirm the absolute configurations of 1-10. Compounds 1-9 were classified as ent-atisane diterpenoids, and 10 was assigned as an ent-kaurane diterpenoid. The biological evaluation of nitric oxide (NO) production inhibition was conducted, and all of these isolates showed the property of inhibiting NO generation in lipopolysaccharide-induced BV-2 cells. Further research on molecular docking disclosed the affinities between the diterpenoids obtained and inducible nitric oxide synthase.

Original languageEnglish
Pages (from-to)1634-1644
Number of pages11
JournalJournal of Natural Products
Volume82
Issue number6
DOIs
Publication statusPublished - 2019 Jun 28

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Euphorbia
Diterpenes
Nitric Oxide
Kaurane Diterpenes
Nitric Oxide Synthase Type II
Circular Dichroism
Lipopolysaccharides
Research

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

Liang, Y., An, L., Shi, Z., Zhang, X., Xie, C., Tuerhong, M., ... Guo, Y. (2019). Bioactive Diterpenoids from the Stems of Euphorbia antiquorum. Journal of Natural Products, 82(6), 1634-1644. https://doi.org/10.1021/acs.jnatprod.9b00134

Bioactive Diterpenoids from the Stems of Euphorbia antiquorum. / Liang, Yue; An, Lijun; Shi, Zhaoyu; Zhang, Xuke; Xie, Chunfeng; Tuerhong, Muhetaer; Song, Zhaohui; Ohizumi, Yasushi; Lee, Dongho; Shuai, Ling; Xu, Jing; Guo, Yuanqiang.

In: Journal of Natural Products, Vol. 82, No. 6, 28.06.2019, p. 1634-1644.

Research output: Contribution to journalArticle

Liang, Y, An, L, Shi, Z, Zhang, X, Xie, C, Tuerhong, M, Song, Z, Ohizumi, Y, Lee, D, Shuai, L, Xu, J & Guo, Y 2019, 'Bioactive Diterpenoids from the Stems of Euphorbia antiquorum', Journal of Natural Products, vol. 82, no. 6, pp. 1634-1644. https://doi.org/10.1021/acs.jnatprod.9b00134
Liang Y, An L, Shi Z, Zhang X, Xie C, Tuerhong M et al. Bioactive Diterpenoids from the Stems of Euphorbia antiquorum. Journal of Natural Products. 2019 Jun 28;82(6):1634-1644. https://doi.org/10.1021/acs.jnatprod.9b00134
Liang, Yue ; An, Lijun ; Shi, Zhaoyu ; Zhang, Xuke ; Xie, Chunfeng ; Tuerhong, Muhetaer ; Song, Zhaohui ; Ohizumi, Yasushi ; Lee, Dongho ; Shuai, Ling ; Xu, Jing ; Guo, Yuanqiang. / Bioactive Diterpenoids from the Stems of Euphorbia antiquorum. In: Journal of Natural Products. 2019 ; Vol. 82, No. 6. pp. 1634-1644.
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