Abstract
A total of 18 diterpenoids, including 10 new analogues (1-10), were isolated from Euphorbia antiquorum. The structures were characterized by spectroscopic techniques, and circular dichroism data analysis was adopted to confirm the absolute configurations of 1-10. Compounds 1-9 were classified as ent-atisane diterpenoids, and 10 was assigned as an ent-kaurane diterpenoid. The biological evaluation of nitric oxide (NO) production inhibition was conducted, and all of these isolates showed the property of inhibiting NO generation in lipopolysaccharide-induced BV-2 cells. Further research on molecular docking disclosed the affinities between the diterpenoids obtained and inducible nitric oxide synthase.
| Original language | English |
|---|---|
| Pages (from-to) | 1634-1644 |
| Number of pages | 11 |
| Journal | Journal of Natural Products |
| Volume | 82 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2019 Jun 28 |
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ASJC Scopus subject areas
- Analytical Chemistry
- Molecular Medicine
- Pharmacology
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry
Cite this
Bioactive Diterpenoids from the Stems of Euphorbia antiquorum. / Liang, Yue; An, Lijun; Shi, Zhaoyu; Zhang, Xuke; Xie, Chunfeng; Tuerhong, Muhetaer; Song, Zhaohui; Ohizumi, Yasushi; Lee, Dongho; Shuai, Ling; Xu, Jing; Guo, Yuanqiang.
In: Journal of Natural Products, Vol. 82, No. 6, 28.06.2019, p. 1634-1644.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Bioactive Diterpenoids from the Stems of Euphorbia antiquorum
AU - Liang, Yue
AU - An, Lijun
AU - Shi, Zhaoyu
AU - Zhang, Xuke
AU - Xie, Chunfeng
AU - Tuerhong, Muhetaer
AU - Song, Zhaohui
AU - Ohizumi, Yasushi
AU - Lee, Dongho
AU - Shuai, Ling
AU - Xu, Jing
AU - Guo, Yuanqiang
PY - 2019/6/28
Y1 - 2019/6/28
N2 - A total of 18 diterpenoids, including 10 new analogues (1-10), were isolated from Euphorbia antiquorum. The structures were characterized by spectroscopic techniques, and circular dichroism data analysis was adopted to confirm the absolute configurations of 1-10. Compounds 1-9 were classified as ent-atisane diterpenoids, and 10 was assigned as an ent-kaurane diterpenoid. The biological evaluation of nitric oxide (NO) production inhibition was conducted, and all of these isolates showed the property of inhibiting NO generation in lipopolysaccharide-induced BV-2 cells. Further research on molecular docking disclosed the affinities between the diterpenoids obtained and inducible nitric oxide synthase.
AB - A total of 18 diterpenoids, including 10 new analogues (1-10), were isolated from Euphorbia antiquorum. The structures were characterized by spectroscopic techniques, and circular dichroism data analysis was adopted to confirm the absolute configurations of 1-10. Compounds 1-9 were classified as ent-atisane diterpenoids, and 10 was assigned as an ent-kaurane diterpenoid. The biological evaluation of nitric oxide (NO) production inhibition was conducted, and all of these isolates showed the property of inhibiting NO generation in lipopolysaccharide-induced BV-2 cells. Further research on molecular docking disclosed the affinities between the diterpenoids obtained and inducible nitric oxide synthase.
UR - http://www.scopus.com/inward/record.url?scp=85067411703&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85067411703&partnerID=8YFLogxK
U2 - 10.1021/acs.jnatprod.9b00134
DO - 10.1021/acs.jnatprod.9b00134
M3 - Article
C2 - 31180680
AN - SCOPUS:85067411703
VL - 82
SP - 1634
EP - 1644
JO - Journal of Natural Products
JF - Journal of Natural Products
SN - 0163-3864
IS - 6
ER -