TY - JOUR
T1 - Bioactive Diterpenoids from the Stems of Euphorbia antiquorum
AU - Liang, Yue
AU - An, Lijun
AU - Shi, Zhaoyu
AU - Zhang, Xuke
AU - Xie, Chunfeng
AU - Tuerhong, Muhetaer
AU - Song, Zhaohui
AU - Ohizumi, Yasushi
AU - Lee, Dongho
AU - Shuai, Ling
AU - Xu, Jing
AU - Guo, Yuanqiang
N1 - Funding Information:
This research was supported financially by the National Natural Science Foundation of China (Nos. U1703107 and U1801288), the National Key Research and Development Program of China (No. 2018YFA0507204), the Fundamental Research Funds for the Central Universities (Nankai University, No. 63191142), Hundred Young Academic Leaders Program of Nankai University, and State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University, No. CMEMR2018-B02).
PY - 2019/6/28
Y1 - 2019/6/28
N2 - A total of 18 diterpenoids, including 10 new analogues (1-10), were isolated from Euphorbia antiquorum. The structures were characterized by spectroscopic techniques, and circular dichroism data analysis was adopted to confirm the absolute configurations of 1-10. Compounds 1-9 were classified as ent-atisane diterpenoids, and 10 was assigned as an ent-kaurane diterpenoid. The biological evaluation of nitric oxide (NO) production inhibition was conducted, and all of these isolates showed the property of inhibiting NO generation in lipopolysaccharide-induced BV-2 cells. Further research on molecular docking disclosed the affinities between the diterpenoids obtained and inducible nitric oxide synthase.
AB - A total of 18 diterpenoids, including 10 new analogues (1-10), were isolated from Euphorbia antiquorum. The structures were characterized by spectroscopic techniques, and circular dichroism data analysis was adopted to confirm the absolute configurations of 1-10. Compounds 1-9 were classified as ent-atisane diterpenoids, and 10 was assigned as an ent-kaurane diterpenoid. The biological evaluation of nitric oxide (NO) production inhibition was conducted, and all of these isolates showed the property of inhibiting NO generation in lipopolysaccharide-induced BV-2 cells. Further research on molecular docking disclosed the affinities between the diterpenoids obtained and inducible nitric oxide synthase.
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U2 - 10.1021/acs.jnatprod.9b00134
DO - 10.1021/acs.jnatprod.9b00134
M3 - Article
C2 - 31180680
AN - SCOPUS:85067411703
VL - 82
SP - 1634
EP - 1644
JO - Journal of Natural Products
JF - Journal of Natural Products
SN - 0163-3864
IS - 6
ER -