Bioactive Diterpenoids from the Stems of Euphorbia antiquorum

Yue Liang; Lijun An; Zhaoyu Shi; Xuke Zhang; Chunfeng Xie; Muhetaer Tuerhong; Zhaohui Song; Yasushi Ohizumi; Dongho Lee; Ling Shuai; Jing Xu; Yuanqiang Guo

doi:10.1021/acs.jnatprod.9b00134

Bioactive Diterpenoids from the Stems of Euphorbia antiquorum

Yue Liang, Lijun An, Zhaoyu Shi, Xuke Zhang, Chunfeng Xie, Muhetaer Tuerhong, Zhaohui Song, Yasushi Ohizumi, Dongho Lee, Ling Shuai, Jing Xu, Yuanqiang Guo

Department of Biosystems and Biotechnology

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

A total of 18 diterpenoids, including 10 new analogues (1-10), were isolated from Euphorbia antiquorum. The structures were characterized by spectroscopic techniques, and circular dichroism data analysis was adopted to confirm the absolute configurations of 1-10. Compounds 1-9 were classified as ent-atisane diterpenoids, and 10 was assigned as an ent-kaurane diterpenoid. The biological evaluation of nitric oxide (NO) production inhibition was conducted, and all of these isolates showed the property of inhibiting NO generation in lipopolysaccharide-induced BV-2 cells. Further research on molecular docking disclosed the affinities between the diterpenoids obtained and inducible nitric oxide synthase.

Original language	English
Pages (from-to)	1634-1644
Number of pages	11
Journal	Journal of Natural Products
Volume	82
Issue number	6
DOIs	https://doi.org/10.1021/acs.jnatprod.9b00134
Publication status	Published - 2019 Jun 28

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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Bioactive Diterpenoids from the Stems of Euphorbia antiquorum. / Liang, Yue; An, Lijun; Shi, Zhaoyu; Zhang, Xuke; Xie, Chunfeng; Tuerhong, Muhetaer; Song, Zhaohui; Ohizumi, Yasushi; Lee, Dongho; Shuai, Ling; Xu, Jing; Guo, Yuanqiang.

In: Journal of Natural Products, Vol. 82, No. 6, 28.06.2019, p. 1634-1644.

Research output: Contribution to journal › Article › peer-review

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AU - Xie, Chunfeng

AU - Tuerhong, Muhetaer

AU - Song, Zhaohui

AU - Ohizumi, Yasushi

AU - Lee, Dongho

AU - Shuai, Ling

AU - Xu, Jing

AU - Guo, Yuanqiang

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