Bioactive diterpenoids from the stems of euphorbia royleana

Peixia Wang; Chunfeng Xie; Lijun An; Xueyuan Yang; Yaru Xi; Shuo Yuan; Chenyue Zhang; Muhetaer Tuerhong; Da Qing Jin; Dongho Lee; Jie Zhang; Yasushi Ohizumi; Jing Xu; Yuanqiang Guo

doi:10.1021/acs.jnatprod.8b00493

Bioactive diterpenoids from the stems of euphorbia royleana

Peixia Wang, Chunfeng Xie, Lijun An, Xueyuan Yang, Yaru Xi, Shuo Yuan, Chenyue Zhang, Muhetaer Tuerhong, Da Qing Jin, Dongho Lee, Jie Zhang, Yasushi Ohizumi, Jing Xu, Yuanqiang Guo

Division of Biotechnology

Research output: Contribution to journal › Article

9 Citations (Scopus)

Abstract

Two ingenane- (1 and 2), two ent-atisane- (3 and 4), two ent-kaurane- (5 and 6), two ent-abietane- (7 and 8), and one ent-isopimarane-type (9) diterpenoid and 12 known analogues have been isolated from the methanolic extract of the stems of Euphorbia royleana. Their structures, including absolute configurations, were determined by extensive spectroscopic methods and ECD data analysis. The nitric oxide inhibitory activities of those diterpenoids were examined biologically in lipopolysaccharide-stimulated BV-2 cells, with compounds 1, 2, 5-7, 10, and 12 having IC ₅₀ values lower than 40 μM. Molecular docking was used to investigated the possible mechanism of compounds 1, 2, 5-7, 10, and 12.

Original language	English
Pages (from-to)	183-193
Number of pages	11
Journal	Journal of Natural Products
Volume	82
Issue number	2
DOIs	https://doi.org/10.1021/acs.jnatprod.8b00493
Publication status	Published - 2019 Feb 22

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

Access to Document

10.1021/acs.jnatprod.8b00493

Fingerprint Dive into the research topics of 'Bioactive diterpenoids from the stems of euphorbia royleana'. Together they form a unique fingerprint.

Cite this

Wang, P., Xie, C., An, L., Yang, X., Xi, Y., Yuan, S., Zhang, C., Tuerhong, M., Jin, D. Q., Lee, D., Zhang, J., Ohizumi, Y., Xu, J., & Guo, Y. (2019). Bioactive diterpenoids from the stems of euphorbia royleana. Journal of Natural Products, 82(2), 183-193. https://doi.org/10.1021/acs.jnatprod.8b00493

Bioactive diterpenoids from the stems of euphorbia royleana. / Wang, Peixia; Xie, Chunfeng; An, Lijun; Yang, Xueyuan; Xi, Yaru; Yuan, Shuo; Zhang, Chenyue; Tuerhong, Muhetaer; Jin, Da Qing; Lee, Dongho; Zhang, Jie; Ohizumi, Yasushi; Xu, Jing; Guo, Yuanqiang.

In: Journal of Natural Products, Vol. 82, No. 2, 22.02.2019, p. 183-193.

Research output: Contribution to journal › Article

@article{85cba3e758f5458c8d25fe7eb9d88bad,

title = "Bioactive diterpenoids from the stems of euphorbia royleana",

abstract = " Two ingenane- (1 and 2), two ent-atisane- (3 and 4), two ent-kaurane- (5 and 6), two ent-abietane- (7 and 8), and one ent-isopimarane-type (9) diterpenoid and 12 known analogues have been isolated from the methanolic extract of the stems of Euphorbia royleana. Their structures, including absolute configurations, were determined by extensive spectroscopic methods and ECD data analysis. The nitric oxide inhibitory activities of those diterpenoids were examined biologically in lipopolysaccharide-stimulated BV-2 cells, with compounds 1, 2, 5-7, 10, and 12 having IC 50 values lower than 40 μM. Molecular docking was used to investigated the possible mechanism of compounds 1, 2, 5-7, 10, and 12. ",

author = "Peixia Wang and Chunfeng Xie and Lijun An and Xueyuan Yang and Yaru Xi and Shuo Yuan and Chenyue Zhang and Muhetaer Tuerhong and Jin, {Da Qing} and Dongho Lee and Jie Zhang and Yasushi Ohizumi and Jing Xu and Yuanqiang Guo",

year = "2019",

month = feb,

day = "22",

doi = "10.1021/acs.jnatprod.8b00493",

language = "English",

volume = "82",

pages = "183--193",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "2",

}

TY - JOUR

T1 - Bioactive diterpenoids from the stems of euphorbia royleana

AU - Wang, Peixia

AU - Xie, Chunfeng

AU - An, Lijun

AU - Yang, Xueyuan

AU - Xi, Yaru

AU - Yuan, Shuo

AU - Zhang, Chenyue

AU - Tuerhong, Muhetaer

AU - Jin, Da Qing

AU - Lee, Dongho

AU - Zhang, Jie

AU - Ohizumi, Yasushi

AU - Xu, Jing

AU - Guo, Yuanqiang

PY - 2019/2/22

Y1 - 2019/2/22

N2 - Two ingenane- (1 and 2), two ent-atisane- (3 and 4), two ent-kaurane- (5 and 6), two ent-abietane- (7 and 8), and one ent-isopimarane-type (9) diterpenoid and 12 known analogues have been isolated from the methanolic extract of the stems of Euphorbia royleana. Their structures, including absolute configurations, were determined by extensive spectroscopic methods and ECD data analysis. The nitric oxide inhibitory activities of those diterpenoids were examined biologically in lipopolysaccharide-stimulated BV-2 cells, with compounds 1, 2, 5-7, 10, and 12 having IC 50 values lower than 40 μM. Molecular docking was used to investigated the possible mechanism of compounds 1, 2, 5-7, 10, and 12.

AB - Two ingenane- (1 and 2), two ent-atisane- (3 and 4), two ent-kaurane- (5 and 6), two ent-abietane- (7 and 8), and one ent-isopimarane-type (9) diterpenoid and 12 known analogues have been isolated from the methanolic extract of the stems of Euphorbia royleana. Their structures, including absolute configurations, were determined by extensive spectroscopic methods and ECD data analysis. The nitric oxide inhibitory activities of those diterpenoids were examined biologically in lipopolysaccharide-stimulated BV-2 cells, with compounds 1, 2, 5-7, 10, and 12 having IC 50 values lower than 40 μM. Molecular docking was used to investigated the possible mechanism of compounds 1, 2, 5-7, 10, and 12.

UR - http://www.scopus.com/inward/record.url?scp=85061489083&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85061489083&partnerID=8YFLogxK

U2 - 10.1021/acs.jnatprod.8b00493

DO - 10.1021/acs.jnatprod.8b00493

M3 - Article

C2 - 30730729

AN - SCOPUS:85061489083

VL - 82

SP - 183

EP - 193

JO - Journal of Natural Products

JF - Journal of Natural Products

SN - 0163-3864

IS - 2

ER -