TY - JOUR
T1 - Bioactive diterpenoids from the stems of euphorbia royleana
AU - Wang, Peixia
AU - Xie, Chunfeng
AU - An, Lijun
AU - Yang, Xueyuan
AU - Xi, Yaru
AU - Yuan, Shuo
AU - Zhang, Chenyue
AU - Tuerhong, Muhetaer
AU - Jin, Da Qing
AU - Lee, Dongho
AU - Zhang, Jie
AU - Ohizumi, Yasushi
AU - Xu, Jing
AU - Guo, Yuanqiang
N1 - Funding Information:
This research was financially supported by the National Natural Science Foundation of China (Nos. U1703107, 21642016, and 21372125), the National Key Research and Development Program of China (No. 2018YFA0507204), the Hundred Young Academic Leaders Program of Nankai University, the Natural Science Foundation of Tianjin, China (No. 16JCYBJC27700), and the Fundamental Research Funds for the Central Universities.
Publisher Copyright:
© 2019 American Chemical Society and American Society of Pharmacognosy.
PY - 2019/2/22
Y1 - 2019/2/22
N2 - Two ingenane- (1 and 2), two ent-atisane- (3 and 4), two ent-kaurane- (5 and 6), two ent-abietane- (7 and 8), and one ent-isopimarane-type (9) diterpenoid and 12 known analogues have been isolated from the methanolic extract of the stems of Euphorbia royleana. Their structures, including absolute configurations, were determined by extensive spectroscopic methods and ECD data analysis. The nitric oxide inhibitory activities of those diterpenoids were examined biologically in lipopolysaccharide-stimulated BV-2 cells, with compounds 1, 2, 5-7, 10, and 12 having IC 50 values lower than 40 μM. Molecular docking was used to investigated the possible mechanism of compounds 1, 2, 5-7, 10, and 12.
AB - Two ingenane- (1 and 2), two ent-atisane- (3 and 4), two ent-kaurane- (5 and 6), two ent-abietane- (7 and 8), and one ent-isopimarane-type (9) diterpenoid and 12 known analogues have been isolated from the methanolic extract of the stems of Euphorbia royleana. Their structures, including absolute configurations, were determined by extensive spectroscopic methods and ECD data analysis. The nitric oxide inhibitory activities of those diterpenoids were examined biologically in lipopolysaccharide-stimulated BV-2 cells, with compounds 1, 2, 5-7, 10, and 12 having IC 50 values lower than 40 μM. Molecular docking was used to investigated the possible mechanism of compounds 1, 2, 5-7, 10, and 12.
UR - http://www.scopus.com/inward/record.url?scp=85061489083&partnerID=8YFLogxK
U2 - 10.1021/acs.jnatprod.8b00493
DO - 10.1021/acs.jnatprod.8b00493
M3 - Article
C2 - 30730729
AN - SCOPUS:85061489083
VL - 82
SP - 183
EP - 193
JO - Journal of Natural Products
JF - Journal of Natural Products
SN - 0163-3864
IS - 2
ER -