Bioactive glass microspheres as reinforcement for improving the mechanical properties and biological performance of poly(e-μ-caprolactone) polymer for bone tissue regeneration

Bo Lei, Kwan Ha Shin, Da Young Noh, Young-Hag Koh, Won Young Choi, Hyoun Ee Kim

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

This study examined the utility of sol-gel-derived bioactive glass microspheres (BGMs) as a reinforcement to improve the mechanical properties and biological performance of poly(eμ-caprolactone) (PCL) polymer. All of the PCL-BGMs composites produced, with a variety of BGMs contents (10, 20, and 30 wt %), showed a uniform distribution of the BGMs in the PCL matrix, particularly owing to their spherical shape and small size. This led to a considerable increase in the elastic modulus from 93 ± 12 MPa to 635 ± 179 MPa with increasing BGMs content from 0 to 30 wt %. Furthermore, the addition of the BGMs to the PCL polymer significantly increased the hydrophilicity of the PCL-BGMs composites, which led to a higher water absorption and degradation rate. The PCL-BGMs composite with a BGMs content of 30 wt % showed vigorous growth of apatite crystals with a high aspect ratio on its surface after soaking in the simulated body fluid for 7 days, resulting in the creation of a porous carbonate hydroxyapatite layer.

Original languageEnglish
Pages (from-to)967-975
Number of pages9
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Volume100 B
Issue number4
DOIs
Publication statusPublished - 2012 May 1

Fingerprint

Tissue regeneration
Bioactive glass
Bone Regeneration
Microspheres
Glass
Reinforcement
Polymers
Bone
Bone and Bones
Mechanical properties
Composite materials
caprolactone
polycaprolactone
Apatites
Elastic Modulus
Body fluids
Carbonates
Apatite
Hydrophilicity
Body Fluids

Keywords

  • bioactive glass
  • composite
  • mechanical properties
  • polymer
  • sol-gel

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials

Cite this

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abstract = "This study examined the utility of sol-gel-derived bioactive glass microspheres (BGMs) as a reinforcement to improve the mechanical properties and biological performance of poly(eμ-caprolactone) (PCL) polymer. All of the PCL-BGMs composites produced, with a variety of BGMs contents (10, 20, and 30 wt {\%}), showed a uniform distribution of the BGMs in the PCL matrix, particularly owing to their spherical shape and small size. This led to a considerable increase in the elastic modulus from 93 ± 12 MPa to 635 ± 179 MPa with increasing BGMs content from 0 to 30 wt {\%}. Furthermore, the addition of the BGMs to the PCL polymer significantly increased the hydrophilicity of the PCL-BGMs composites, which led to a higher water absorption and degradation rate. The PCL-BGMs composite with a BGMs content of 30 wt {\%} showed vigorous growth of apatite crystals with a high aspect ratio on its surface after soaking in the simulated body fluid for 7 days, resulting in the creation of a porous carbonate hydroxyapatite layer.",
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AU - Shin, Kwan Ha

AU - Noh, Da Young

AU - Koh, Young-Hag

AU - Choi, Won Young

AU - Kim, Hyoun Ee

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