Bioactive lipoxygenase metabolites stimulation of NADPH oxidases and reactive oxygen species

Kyung Jin Cho, Ji Min Seo, Jae-Hong Kim

Research output: Contribution to journalArticle

71 Citations (Scopus)

Abstract

In mammalian cells, reactive oxygen species (ROS) are produced via a variety of cellular oxidative processes, including the activity of NADPH oxidases (NOX), the activity of xanthine oxidases, the metabolism of arachidonic acid (AA) by lipoxygenases (LOX) and cyclooxygenases (COX), and the mitochondrial respiratory chain. Although NOX-generated ROS are the best characterized examples of ROS in mammalian cells, ROS are also generated by the oxidative metabolism (e.g., via LOX and COX) of AA that is released from the membrane phospholipids via the activity of cytosolic phospholipase A 2 (cPLA 2). Recently, growing evidence suggests that LOX- and COX-generated AA metabolites can induce ROS generation by stimulating NOX and that a potential signaling connection exits between the LOX/COX metabolites and NOX. In this review, we discuss the results of recent studies that report the generation of ROS by LOX metabolites, especially 5-LOX metabolites, via NOX stimulation. In particular, we have focused on the contribution of leukotriene B 4 (LTB 4), a potent bioactive eicosanoid that is derived from 5-LOX, and its receptors, BLT1 and BLT2, to NOX stimulation through a signaling mechanism that leads to ROS generation.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalMolecules and Cells
Volume32
Issue number1
DOIs
Publication statusPublished - 2011 Jul 1

Fingerprint

Lipoxygenase
NADPH Oxidase
Reactive Oxygen Species
Lipoxygenases
Prostaglandin-Endoperoxide Synthases
Arachidonate Lipoxygenases
Arachidonate 5-Lipoxygenase
Leukotriene B4
Eicosanoids
Xanthine Oxidase
Phospholipases A
Electron Transport
Phospholipids
Membranes

Keywords

  • BLT2
  • eicosanoids
  • lipoxygenase
  • NOX
  • ROS

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Bioactive lipoxygenase metabolites stimulation of NADPH oxidases and reactive oxygen species. / Cho, Kyung Jin; Seo, Ji Min; Kim, Jae-Hong.

In: Molecules and Cells, Vol. 32, No. 1, 01.07.2011, p. 1-5.

Research output: Contribution to journalArticle

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