Bioactive prenylated flavonoids from the stem bark of Artocarpus kemando

Eun Kyoung Seo, Dongho Lee, Geun Shin Young, Hee Byung Chai, Hernán A. Navarro, Leonardus B S Kardono, Ismail Rahman, Geoffrey A. Cordell, Norman R. Farnsworth, John M. Pezzuto, A. Douglas Kinghorn, Mansukh C. Wani, Monroe E. Wall

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Four known prenylated flavonoids, artonins E (1) and O (2), artobiloxanthone (3), and cycloartobiloxanthone (4), were isolated from the stem bark of Artocarpus kemando by bioassay-guided fractionation using the DNA strand-scission and the KB cytotoxicity assays as monitors. Compounds 1 and 3 exhibited strong DNA strand-scission activity, and all four compounds were found to be cytotoxic.

Original languageEnglish
Pages (from-to)124-127
Number of pages4
JournalArchives of Pharmacal Research
Volume26
Issue number2
Publication statusPublished - 2003 Feb 28
Externally publishedYes

Fingerprint

Artocarpus
Flavonoids
Bioassay
DNA
Cytotoxicity
Fractionation
Biological Assay
Assays

Keywords

  • Artocarpus kemando
  • Cytotoxicity
  • DNA strand-scission activity
  • Flavonoids
  • LC-MS dereplication
  • Moraceae

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

Cite this

Seo, E. K., Lee, D., Young, G. S., Chai, H. B., Navarro, H. A., Kardono, L. B. S., ... Wall, M. E. (2003). Bioactive prenylated flavonoids from the stem bark of Artocarpus kemando. Archives of Pharmacal Research, 26(2), 124-127.

Bioactive prenylated flavonoids from the stem bark of Artocarpus kemando. / Seo, Eun Kyoung; Lee, Dongho; Young, Geun Shin; Chai, Hee Byung; Navarro, Hernán A.; Kardono, Leonardus B S; Rahman, Ismail; Cordell, Geoffrey A.; Farnsworth, Norman R.; Pezzuto, John M.; Kinghorn, A. Douglas; Wani, Mansukh C.; Wall, Monroe E.

In: Archives of Pharmacal Research, Vol. 26, No. 2, 28.02.2003, p. 124-127.

Research output: Contribution to journalArticle

Seo, EK, Lee, D, Young, GS, Chai, HB, Navarro, HA, Kardono, LBS, Rahman, I, Cordell, GA, Farnsworth, NR, Pezzuto, JM, Kinghorn, AD, Wani, MC & Wall, ME 2003, 'Bioactive prenylated flavonoids from the stem bark of Artocarpus kemando', Archives of Pharmacal Research, vol. 26, no. 2, pp. 124-127.
Seo EK, Lee D, Young GS, Chai HB, Navarro HA, Kardono LBS et al. Bioactive prenylated flavonoids from the stem bark of Artocarpus kemando. Archives of Pharmacal Research. 2003 Feb 28;26(2):124-127.
Seo, Eun Kyoung ; Lee, Dongho ; Young, Geun Shin ; Chai, Hee Byung ; Navarro, Hernán A. ; Kardono, Leonardus B S ; Rahman, Ismail ; Cordell, Geoffrey A. ; Farnsworth, Norman R. ; Pezzuto, John M. ; Kinghorn, A. Douglas ; Wani, Mansukh C. ; Wall, Monroe E. / Bioactive prenylated flavonoids from the stem bark of Artocarpus kemando. In: Archives of Pharmacal Research. 2003 ; Vol. 26, No. 2. pp. 124-127.
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