Bioactive prenylated flavonoids from the stem bark of Artocarpus kemando

Eun Kyoung Seo, Dongho Lee, Geun Shin Young, Hee Byung Chai, Hernán A. Navarro, Leonardus B.S. Kardono, Ismail Rahman, Geoffrey A. Cordell, Norman R. Farnsworth, John M. Pezzuto, A. Douglas Kinghorn, Mansukh C. Wani, Monroe E. Wall

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Four known prenylated flavonoids, artonins E (1) and O (2), artobiloxanthone (3), and cycloartobiloxanthone (4), were isolated from the stem bark of Artocarpus kemando by bioassay-guided fractionation using the DNA strand-scission and the KB cytotoxicity assays as monitors. Compounds 1 and 3 exhibited strong DNA strand-scission activity, and all four compounds were found to be cytotoxic.

Original languageEnglish
Pages (from-to)124-127
Number of pages4
JournalArchives of pharmacal research
Volume26
Issue number2
DOIs
Publication statusPublished - 2003 Feb 28

Keywords

  • Artocarpus kemando
  • Cytotoxicity
  • DNA strand-scission activity
  • Flavonoids
  • LC-MS dereplication
  • Moraceae

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

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    Seo, E. K., Lee, D., Young, G. S., Chai, H. B., Navarro, H. A., Kardono, L. B. S., Rahman, I., Cordell, G. A., Farnsworth, N. R., Pezzuto, J. M., Kinghorn, A. D., Wani, M. C., & Wall, M. E. (2003). Bioactive prenylated flavonoids from the stem bark of Artocarpus kemando. Archives of pharmacal research, 26(2), 124-127. https://doi.org/10.1007/bf02976656