@article{72fabf1d161a465b8b55658782714a80,
title = "Bioactive terpenoids from Euonymus verrucosus var. pauciflorus showing NO inhibitory activities",
abstract = "In our continuous search for new nitric oxide (NO) inhibitory compounds as potential anti-inflammatory agents or lead compounds for inflammatory diseases, the chemical constituents of Euonymus verrucosus var. pauciflorus were investigated, leading to the isolation of eleven terpenoids including six new diterpenoids, designated as euonymupenes A–F. The structures were elucidated on the basis of NMR and ECD data analysis. Euonymupenes A, C, and F feature rare labdane-type norditerpenoid skeletons. The NO inhibitory effects were evaluated and all of the isolates were found to inhibit lipopolysaccharide (LPS)-induced NO production in murine microglial BV-2 cells. Western blotting analysis indicated that the most active compound (5) can regulate iNOS (inducible nitric oxide synthase) expression. The further molecular docking studies exhibited the affinities of bioactive compounds with iNOS.",
keywords = "Celastraceae, Euonymus verrucosus var. pauciflorus, NO inhibitory activities, Norditerpenoids, iNOS",
author = "Yuling Yang and Xueyuan Yang and Xuke Zhang and Ziteng Song and Feng Liu and Yue Liang and Jie Zhang and Jin, {Da Qing} and Jing Xu and Dongho Lee and Muhetaer Tuerhong and Yasushi Ohizumi and Yuanqiang Guo",
note = "Funding Information: This research was supported by the National Key Research and Development Program of China (No. 2018YFA0507204 ), the Natural Science Foundation of Tianjin, China (No. 16JCYBJC27700 ), National Natural Science Foundation of China (Nos. U1703107 , 21642016 , and 21372125 ), Hundred Young Academic Leaders Program of Nankai University, State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University, No. CMEMR2018-B02 ), and the Fundamental Research Funds for the Central Universities . Funding Information: This research was supported by the National Key Research and Development Program of China (No. 2018YFA0507204), the Natural Science Foundation of Tianjin, China (No. 16JCYBJC27700), National Natural Science Foundation of China (Nos. U1703107, 21642016, and 21372125), Hundred Young Academic Leaders Program of Nankai University, State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University, No. CMEMR2018-B02), and the Fundamental Research Funds for the Central Universities. Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
year = "2019",
month = jun,
doi = "10.1016/j.bioorg.2019.03.022",
language = "English",
volume = "87",
pages = "447--456",
journal = "Bioorganic Chemistry",
issn = "0045-2068",
publisher = "Academic Press Inc.",
}