Bioactive Terpenoids from Salvia plebeia: Structures, NO Inhibitory Activities, and Interactions with iNOS

Jing Xu, Meicheng Wang, Xiaocong Sun, Quanhui Ren, Xiangrong Cao, Shen Li, Guochen Su, Muhetaer Tuerhong, Dongho Lee, Yasushi Ohizumi, Mark Bartlam, Yuanqiang Guo

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

A phytochemical investigation to obtain new NO inhibitors resulted in the identification of six new (1-6) and four known (7-10) terpenoids from Salvia plebeia. Compounds 1 and 2 are new diterpenoids, 3-5 are new meroditerpenoids, 6-9 are sesquiterpenoids, and 10 is a known meroditerpenoid. The structures of these isolates were determined by routine NMR experiments and X-ray diffraction, as well as the electronic circular dichroism spectra. Compounds 1-4 are diterpenoids carrying an oxygen bridge, and 6 is a rare copane-type sesquiterpenoid with a bridged tricyclic framework. The isolates inhibited NO generation induced by lipopolysaccharide in BV-2 cells. The possible mechanism of NO inhibition of some bioactive compounds was also investigated using molecular docking, which revealed interactions of bioactive compounds with the iNOS protein.

Original languageEnglish
Pages (from-to)2924-2932
Number of pages9
JournalJournal of Natural Products
Volume79
Issue number11
DOIs
Publication statusPublished - 2016 Nov 23

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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