TY - JOUR
T1 - Bioactive triterpenoids from callistemon lanceolatus
AU - Jeong, Wonsik
AU - Hong, Seong Su
AU - Kim, Nahyun
AU - Yang, Young Taek
AU - Shin, Yu Su
AU - Lee, Chul
AU - Hwang, Bang Yeon
AU - Lee, Dongho
N1 - Funding Information:
This work was supported by a Korea University (KU) Grant to D. Lee. We thank Cooperative Center for Analytical Instruments at KU for providing some of the equipment used in this study.
Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2009/6
Y1 - 2009/6
N2 - A new triterpenoid, 30-hydroxyalphitolic acid 1, and eight known triterpenoids, alphitolic acid 2, lupenol 3, 3-acetoxy-olean-18-en-28-oic acid 4, betulinic acid 5, ursolic acid 6, betulinic acid 3-O-caffeate 7, morolic acid 3-O-caffeate 8, and ursolic acid 3-O-caffeate 9, were isolated from Callistemon lanceolatus. Their structures were determined using spectroscopic techniques, which included 1D- and 2D-NMR. All compounds were evaluated for the inhibition of LPS-induced nitric oxide production in murine macrophage RAW264.7 cells. Betulinic acid 3-O-caffeate 7 showed a moderate inhibitory effect on nitric oxide production with IC50 value of 15.4 μM.
AB - A new triterpenoid, 30-hydroxyalphitolic acid 1, and eight known triterpenoids, alphitolic acid 2, lupenol 3, 3-acetoxy-olean-18-en-28-oic acid 4, betulinic acid 5, ursolic acid 6, betulinic acid 3-O-caffeate 7, morolic acid 3-O-caffeate 8, and ursolic acid 3-O-caffeate 9, were isolated from Callistemon lanceolatus. Their structures were determined using spectroscopic techniques, which included 1D- and 2D-NMR. All compounds were evaluated for the inhibition of LPS-induced nitric oxide production in murine macrophage RAW264.7 cells. Betulinic acid 3-O-caffeate 7 showed a moderate inhibitory effect on nitric oxide production with IC50 value of 15.4 μM.
KW - Betulinic acid 3-O-caffeate
KW - Callistemon lanceolatus
KW - Myrtaceae
KW - NO production inhibitor
KW - Triterpenoids
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U2 - 10.1007/s12272-009-1605-3
DO - 10.1007/s12272-009-1605-3
M3 - Article
C2 - 19557361
AN - SCOPUS:68149160163
SN - 0253-6269
VL - 32
SP - 845
EP - 849
JO - Archives of Pharmacal Research
JF - Archives of Pharmacal Research
IS - 6
ER -