Bioactive triterpenoids from callistemon lanceolatus

Wonsik Jeong, Seong Su Hong, Nahyun Kim, Young Taek Yang, Yu Su Shin, Chul Lee, Bang Yeon Hwang, Dongho Lee

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

A new triterpenoid, 30-hydroxyalphitolic acid 1, and eight known triterpenoids, alphitolic acid 2, lupenol 3, 3-acetoxy-olean-18-en-28-oic acid 4, betulinic acid 5, ursolic acid 6, betulinic acid 3-O-caffeate 7, morolic acid 3-O-caffeate 8, and ursolic acid 3-O-caffeate 9, were isolated from Callistemon lanceolatus. Their structures were determined using spectroscopic techniques, which included 1D- and 2D-NMR. All compounds were evaluated for the inhibition of LPS-induced nitric oxide production in murine macrophage RAW264.7 cells. Betulinic acid 3-O-caffeate 7 showed a moderate inhibitory effect on nitric oxide production with IC50 value of 15.4 μM.

Original languageEnglish
Pages (from-to)845-849
Number of pages5
JournalArchives of pharmacal research
Volume32
Issue number6
DOIs
Publication statusPublished - 2009 Jun

Keywords

  • Betulinic acid 3-O-caffeate
  • Callistemon lanceolatus
  • Myrtaceae
  • NO production inhibitor
  • Triterpenoids

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery
  • Organic Chemistry

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  • Cite this

    Jeong, W., Hong, S. S., Kim, N., Yang, Y. T., Shin, Y. S., Lee, C., Hwang, B. Y., & Lee, D. (2009). Bioactive triterpenoids from callistemon lanceolatus. Archives of pharmacal research, 32(6), 845-849. https://doi.org/10.1007/s12272-009-1605-3