Bioactive triterpenoids from callistemon lanceolatus

Wonsik Jeong, Seong Su Hong, Nahyun Kim, Young Taek Yang, Yu Su Shin, Chul Lee, Bang Yeon Hwang, Dongho Lee

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

A new triterpenoid, 30-hydroxyalphitolic acid 1, and eight known triterpenoids, alphitolic acid 2, lupenol 3, 3-acetoxy-olean-18-en-28-oic acid 4, betulinic acid 5, ursolic acid 6, betulinic acid 3-O-caffeate 7, morolic acid 3-O-caffeate 8, and ursolic acid 3-O-caffeate 9, were isolated from Callistemon lanceolatus. Their structures were determined using spectroscopic techniques, which included 1D- and 2D-NMR. All compounds were evaluated for the inhibition of LPS-induced nitric oxide production in murine macrophage RAW264.7 cells. Betulinic acid 3-O-caffeate 7 showed a moderate inhibitory effect on nitric oxide production with IC50 value of 15.4 μM.

Original languageEnglish
Pages (from-to)845-849
Number of pages5
JournalArchives of Pharmacal Research
Volume32
Issue number6
DOIs
Publication statusPublished - 2009 Jun 1

Fingerprint

Nitric Oxide
Acids
Macrophages
Inhibitory Concentration 50
Nuclear magnetic resonance
betulinic acid
ursolic acid
30-hydroxyalphitolic acid
morolic acid

Keywords

  • Betulinic acid 3-O-caffeate
  • Callistemon lanceolatus
  • Myrtaceae
  • NO production inhibitor
  • Triterpenoids

ASJC Scopus subject areas

  • Drug Discovery
  • Molecular Medicine
  • Organic Chemistry

Cite this

Jeong, W., Hong, S. S., Kim, N., Yang, Y. T., Shin, Y. S., Lee, C., ... Lee, D. (2009). Bioactive triterpenoids from callistemon lanceolatus. Archives of Pharmacal Research, 32(6), 845-849. https://doi.org/10.1007/s12272-009-1605-3

Bioactive triterpenoids from callistemon lanceolatus. / Jeong, Wonsik; Hong, Seong Su; Kim, Nahyun; Yang, Young Taek; Shin, Yu Su; Lee, Chul; Hwang, Bang Yeon; Lee, Dongho.

In: Archives of Pharmacal Research, Vol. 32, No. 6, 01.06.2009, p. 845-849.

Research output: Contribution to journalArticle

Jeong, W, Hong, SS, Kim, N, Yang, YT, Shin, YS, Lee, C, Hwang, BY & Lee, D 2009, 'Bioactive triterpenoids from callistemon lanceolatus', Archives of Pharmacal Research, vol. 32, no. 6, pp. 845-849. https://doi.org/10.1007/s12272-009-1605-3
Jeong W, Hong SS, Kim N, Yang YT, Shin YS, Lee C et al. Bioactive triterpenoids from callistemon lanceolatus. Archives of Pharmacal Research. 2009 Jun 1;32(6):845-849. https://doi.org/10.1007/s12272-009-1605-3
Jeong, Wonsik ; Hong, Seong Su ; Kim, Nahyun ; Yang, Young Taek ; Shin, Yu Su ; Lee, Chul ; Hwang, Bang Yeon ; Lee, Dongho. / Bioactive triterpenoids from callistemon lanceolatus. In: Archives of Pharmacal Research. 2009 ; Vol. 32, No. 6. pp. 845-849.
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