Biocompatibility and strength retention of biodegradable Mg-Ca-Zn alloy bone implants

Sung Youn Cho, Soo Won Chae, Kui Won Choi, Hyun Kwang Seok, Yu Chan Kim, Jae Young Jung, Seok Jo Yang, Gyeong Je Kwon, Jong Tack Kim, Michel Assad

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The biocompatibility and strength retention of a Mg-Ca-Zn alloy were studied to evaluate its efficacy for osteosynthesis applications. Mg-Ca-Zn alloy and self-reinforced poly l-lactide (SR-PLLA) bone screws were implanted into New Zealand rabbits for radiography analysis, micro computed tomography analysis, histomorphometry, hematology, serum biochemistry, histopathology, and inductively coupled plasma mass spectrometry analysis. Bending and torsion tests were performed on intact specimens to find the initial mechanical strength of these Mg-Ca-Zn alloy bone screws. Strength retention of the Mg-Ca-Zn alloy implants were calculated from in vivo degradation rates and initial mechanical strength. Based on the animal study, Mg-Ca-Zn alloy bone screw showed absence of subcutaneous gas pockets, characteristic surface erosion properties, faster degradation rate than SR-PLLA bone screw, normal reference range of hematology and serum biochemistry, better histopathological response than SR-PLLA bone screw, and stable concentrations of each constituent element in soft tissues surrounding the implants. The initial strength and strength retention of Mg-Ca-Zn alloy were compared with those of various biomaterials. The initial strength of Mg-Ca-Zn alloy was higher than those of biostable and biodegradable polymers. The strength retention of Mg-Ca-Zn alloy bone screws was similar to those of biodegradable polymer. Therefore, this Mg-Ca-Zn alloy represents an excellent biodegradable biomaterial candidate for osteosynthesis applications.

Original languageEnglish
Pages (from-to)201-212
Number of pages12
JournalJournal of Biomedical Materials Research - Part B Applied Biomaterials
Volume101 B
Issue number2
DOIs
Publication statusPublished - 2013 Nov 11

Fingerprint

Biocompatibility
Bone Screws
Bone
Bone and Bones
Biochemistry
Biodegradable polymers
Biocompatible Materials
Hematology
Biomaterials
Strength of materials
Polymers
Reference Values
Degradation
Inductively coupled plasma mass spectrometry
Surface Properties
Radiography
Serum
Torsional stress
Tomography
Erosion

Keywords

  • Absorbable
  • Biodegradable metal
  • Biodegradation
  • Bone screw
  • Magnesium

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Medicine(all)

Cite this

Biocompatibility and strength retention of biodegradable Mg-Ca-Zn alloy bone implants. / Cho, Sung Youn; Chae, Soo Won; Choi, Kui Won; Seok, Hyun Kwang; Kim, Yu Chan; Jung, Jae Young; Yang, Seok Jo; Kwon, Gyeong Je; Kim, Jong Tack; Assad, Michel.

In: Journal of Biomedical Materials Research - Part B Applied Biomaterials, Vol. 101 B, No. 2, 11.11.2013, p. 201-212.

Research output: Contribution to journalArticle

Cho, Sung Youn ; Chae, Soo Won ; Choi, Kui Won ; Seok, Hyun Kwang ; Kim, Yu Chan ; Jung, Jae Young ; Yang, Seok Jo ; Kwon, Gyeong Je ; Kim, Jong Tack ; Assad, Michel. / Biocompatibility and strength retention of biodegradable Mg-Ca-Zn alloy bone implants. In: Journal of Biomedical Materials Research - Part B Applied Biomaterials. 2013 ; Vol. 101 B, No. 2. pp. 201-212.
@article{cd68efc835624493bfeca1091f3957df,
title = "Biocompatibility and strength retention of biodegradable Mg-Ca-Zn alloy bone implants",
abstract = "The biocompatibility and strength retention of a Mg-Ca-Zn alloy were studied to evaluate its efficacy for osteosynthesis applications. Mg-Ca-Zn alloy and self-reinforced poly l-lactide (SR-PLLA) bone screws were implanted into New Zealand rabbits for radiography analysis, micro computed tomography analysis, histomorphometry, hematology, serum biochemistry, histopathology, and inductively coupled plasma mass spectrometry analysis. Bending and torsion tests were performed on intact specimens to find the initial mechanical strength of these Mg-Ca-Zn alloy bone screws. Strength retention of the Mg-Ca-Zn alloy implants were calculated from in vivo degradation rates and initial mechanical strength. Based on the animal study, Mg-Ca-Zn alloy bone screw showed absence of subcutaneous gas pockets, characteristic surface erosion properties, faster degradation rate than SR-PLLA bone screw, normal reference range of hematology and serum biochemistry, better histopathological response than SR-PLLA bone screw, and stable concentrations of each constituent element in soft tissues surrounding the implants. The initial strength and strength retention of Mg-Ca-Zn alloy were compared with those of various biomaterials. The initial strength of Mg-Ca-Zn alloy was higher than those of biostable and biodegradable polymers. The strength retention of Mg-Ca-Zn alloy bone screws was similar to those of biodegradable polymer. Therefore, this Mg-Ca-Zn alloy represents an excellent biodegradable biomaterial candidate for osteosynthesis applications.",
keywords = "Absorbable, Biodegradable metal, Biodegradation, Bone screw, Magnesium",
author = "Cho, {Sung Youn} and Chae, {Soo Won} and Choi, {Kui Won} and Seok, {Hyun Kwang} and Kim, {Yu Chan} and Jung, {Jae Young} and Yang, {Seok Jo} and Kwon, {Gyeong Je} and Kim, {Jong Tack} and Michel Assad",
year = "2013",
month = "11",
day = "11",
doi = "10.1002/jbm.b.32813",
language = "English",
volume = "101 B",
pages = "201--212",
journal = "Journal of Biomedical Materials Research - Part B Applied Biomaterials",
issn = "1552-4973",
publisher = "John Wiley and Sons Inc.",
number = "2",

}

TY - JOUR

T1 - Biocompatibility and strength retention of biodegradable Mg-Ca-Zn alloy bone implants

AU - Cho, Sung Youn

AU - Chae, Soo Won

AU - Choi, Kui Won

AU - Seok, Hyun Kwang

AU - Kim, Yu Chan

AU - Jung, Jae Young

AU - Yang, Seok Jo

AU - Kwon, Gyeong Je

AU - Kim, Jong Tack

AU - Assad, Michel

PY - 2013/11/11

Y1 - 2013/11/11

N2 - The biocompatibility and strength retention of a Mg-Ca-Zn alloy were studied to evaluate its efficacy for osteosynthesis applications. Mg-Ca-Zn alloy and self-reinforced poly l-lactide (SR-PLLA) bone screws were implanted into New Zealand rabbits for radiography analysis, micro computed tomography analysis, histomorphometry, hematology, serum biochemistry, histopathology, and inductively coupled plasma mass spectrometry analysis. Bending and torsion tests were performed on intact specimens to find the initial mechanical strength of these Mg-Ca-Zn alloy bone screws. Strength retention of the Mg-Ca-Zn alloy implants were calculated from in vivo degradation rates and initial mechanical strength. Based on the animal study, Mg-Ca-Zn alloy bone screw showed absence of subcutaneous gas pockets, characteristic surface erosion properties, faster degradation rate than SR-PLLA bone screw, normal reference range of hematology and serum biochemistry, better histopathological response than SR-PLLA bone screw, and stable concentrations of each constituent element in soft tissues surrounding the implants. The initial strength and strength retention of Mg-Ca-Zn alloy were compared with those of various biomaterials. The initial strength of Mg-Ca-Zn alloy was higher than those of biostable and biodegradable polymers. The strength retention of Mg-Ca-Zn alloy bone screws was similar to those of biodegradable polymer. Therefore, this Mg-Ca-Zn alloy represents an excellent biodegradable biomaterial candidate for osteosynthesis applications.

AB - The biocompatibility and strength retention of a Mg-Ca-Zn alloy were studied to evaluate its efficacy for osteosynthesis applications. Mg-Ca-Zn alloy and self-reinforced poly l-lactide (SR-PLLA) bone screws were implanted into New Zealand rabbits for radiography analysis, micro computed tomography analysis, histomorphometry, hematology, serum biochemistry, histopathology, and inductively coupled plasma mass spectrometry analysis. Bending and torsion tests were performed on intact specimens to find the initial mechanical strength of these Mg-Ca-Zn alloy bone screws. Strength retention of the Mg-Ca-Zn alloy implants were calculated from in vivo degradation rates and initial mechanical strength. Based on the animal study, Mg-Ca-Zn alloy bone screw showed absence of subcutaneous gas pockets, characteristic surface erosion properties, faster degradation rate than SR-PLLA bone screw, normal reference range of hematology and serum biochemistry, better histopathological response than SR-PLLA bone screw, and stable concentrations of each constituent element in soft tissues surrounding the implants. The initial strength and strength retention of Mg-Ca-Zn alloy were compared with those of various biomaterials. The initial strength of Mg-Ca-Zn alloy was higher than those of biostable and biodegradable polymers. The strength retention of Mg-Ca-Zn alloy bone screws was similar to those of biodegradable polymer. Therefore, this Mg-Ca-Zn alloy represents an excellent biodegradable biomaterial candidate for osteosynthesis applications.

KW - Absorbable

KW - Biodegradable metal

KW - Biodegradation

KW - Bone screw

KW - Magnesium

UR - http://www.scopus.com/inward/record.url?scp=84879315746&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84879315746&partnerID=8YFLogxK

U2 - 10.1002/jbm.b.32813

DO - 10.1002/jbm.b.32813

M3 - Article

C2 - 23115061

AN - SCOPUS:84879315746

VL - 101 B

SP - 201

EP - 212

JO - Journal of Biomedical Materials Research - Part B Applied Biomaterials

JF - Journal of Biomedical Materials Research - Part B Applied Biomaterials

SN - 1552-4973

IS - 2

ER -