Biocompatible glycol chitosan-coated gold nanoparticles for tumor-targeting CT imaging

In Cheol Sun, Jin Hee Na, Seo Young Jeong, Dong Eog Kim, Ick Chan Kwon, Kuiwon Choi, Cheol Hee Ahn, Kwangmeyung Kim

Research output: Contribution to journalArticlepeer-review

72 Citations (Scopus)

Abstract

Purpose: The application of gold nanoparticles (AuNPs) in biomedical field was limited due to the low stability in the biological condition. Herein, to enhance stability and tumor targeting ability of AuNPs, their surface was modified with biocompatible glycol chitosan (GC) and the in vivo biodistribution of GC coated AuNPs (GC-AuNPs) were studied through computed tomography (CT). Methods: Polymer-coated gold nanoparticles were produced using GC as a reducing agent and a stabilizer. Their feasibility in biomedical application was explored through CT in tumor-bearing mice. Results: Stability of gold nanoparticles increased in the physiological condition due to the GC coating layer on the surface. Tomographic images of tumor were successfully obtained in the tumor-xenografted animal model when the GC-AuNPs were used as a CT contrast agent. The tumor targeting property of the gold nanoparticles was due to the properties of GC because GC-AuNPs were accumulated in the tumor, while most of heparin-coated nanoparticles were found in the liver and spleen. Conclusions: The polymer properties on the surface played an important role in the behavior of gold nanoparticles in the biological condition and the enhanced stability and tumor targeting property of nanoparticles were inherited from GC on the surface.

Original languageEnglish
Pages (from-to)1418-1425
Number of pages8
JournalPharmaceutical research
Volume31
Issue number6
DOIs
Publication statusPublished - 2014 Jun

Keywords

  • CT contrast agent
  • glycol chitosan
  • gold nanoparticle
  • tumor targeting

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Biocompatible glycol chitosan-coated gold nanoparticles for tumor-targeting CT imaging'. Together they form a unique fingerprint.

Cite this