Biocompatible glycol chitosan-coated gold nanoparticles for tumor-targeting CT imaging

In Cheol Sun, Jin Hee Na, Seo Young Jeong, Dong Eog Kim, Ick Chan Kwon, Kuiwon Choi, Cheol Hee Ahn, Kwang Meyung Kim

Research output: Contribution to journalArticle

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Abstract

Purpose: The application of gold nanoparticles (AuNPs) in biomedical field was limited due to the low stability in the biological condition. Herein, to enhance stability and tumor targeting ability of AuNPs, their surface was modified with biocompatible glycol chitosan (GC) and the in vivo biodistribution of GC coated AuNPs (GC-AuNPs) were studied through computed tomography (CT). Methods: Polymer-coated gold nanoparticles were produced using GC as a reducing agent and a stabilizer. Their feasibility in biomedical application was explored through CT in tumor-bearing mice. Results: Stability of gold nanoparticles increased in the physiological condition due to the GC coating layer on the surface. Tomographic images of tumor were successfully obtained in the tumor-xenografted animal model when the GC-AuNPs were used as a CT contrast agent. The tumor targeting property of the gold nanoparticles was due to the properties of GC because GC-AuNPs were accumulated in the tumor, while most of heparin-coated nanoparticles were found in the liver and spleen. Conclusions: The polymer properties on the surface played an important role in the behavior of gold nanoparticles in the biological condition and the enhanced stability and tumor targeting property of nanoparticles were inherited from GC on the surface.

Original languageEnglish
Pages (from-to)1418-1425
Number of pages8
JournalPharmaceutical Research
Volume31
Issue number6
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Gold
Nanoparticles
Tomography
Tumors
Imaging techniques
Neoplasms
Polymers
Bearings (structural)
Aptitude
Surface Properties
glycol-chitosan
Reducing Agents
Liver
Contrast Media
Heparin
Animals
Spleen
Animal Models
Coatings

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Organic Chemistry
  • Molecular Medicine
  • Pharmacology (medical)
  • Biotechnology
  • Pharmacology

Cite this

Biocompatible glycol chitosan-coated gold nanoparticles for tumor-targeting CT imaging. / Sun, In Cheol; Na, Jin Hee; Jeong, Seo Young; Kim, Dong Eog; Kwon, Ick Chan; Choi, Kuiwon; Ahn, Cheol Hee; Kim, Kwang Meyung.

In: Pharmaceutical Research, Vol. 31, No. 6, 01.01.2014, p. 1418-1425.

Research output: Contribution to journalArticle

Sun, IC, Na, JH, Jeong, SY, Kim, DE, Kwon, IC, Choi, K, Ahn, CH & Kim, KM 2014, 'Biocompatible glycol chitosan-coated gold nanoparticles for tumor-targeting CT imaging', Pharmaceutical Research, vol. 31, no. 6, pp. 1418-1425. https://doi.org/10.1007/s11095-013-1142-0
Sun, In Cheol ; Na, Jin Hee ; Jeong, Seo Young ; Kim, Dong Eog ; Kwon, Ick Chan ; Choi, Kuiwon ; Ahn, Cheol Hee ; Kim, Kwang Meyung. / Biocompatible glycol chitosan-coated gold nanoparticles for tumor-targeting CT imaging. In: Pharmaceutical Research. 2014 ; Vol. 31, No. 6. pp. 1418-1425.
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