Biocompatible polymeric nanoparticles and films containing hydrophobic quantum dots

Jisook Lee, Ick Chan Kwon, Kyoungja Woo, Hesson Chung

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Micro- or nano-particles encapsulating hydrophobic quantum dots were prepared by the emulsion technique. Films containing quantum dots were also prepared by film casting methods. Quantum dots without hydrophilic coating were directly mixed with polymer solution to prepared extremely stable films or particles that do not phase-separate with time. The surface of the particles or films could be modified to have different hydrophilicity and/or functional groups. Particles with 1.5 ± 0.16 um and 320 ± 26 nm in diameters and films of 300 um in thickness were prepared. NIH 3T3 and EMT-6 were culture on the films containing quantum dots for 8 -20 h. Compared to the control, quantum dot were delivered directly and efficiently into the cells without toxicity. When implanted near tumor cells in Balb/C mice, quantum dots migrated from the films into the tumor cells for at least 3 days. Considering that the quantum dot dispersion in aqueous media is relatively unstable and difficult to handle, our stable particles or films containing hydrophobic quantum dots can become versatile probes for biological applications.

Original languageEnglish
Title of host publicationMaterials Research Society Symposium Proceedings
Pages52-56
Number of pages5
Publication statusPublished - 2006 Dec 1
Event2006 MRS Fall Meeting - Boston, MA, United States
Duration: 2006 Nov 272006 Dec 1

Publication series

NameMaterials Research Society Symposium Proceedings
Volume950
ISSN (Print)0272-9172

Other

Other2006 MRS Fall Meeting
CountryUnited States
CityBoston, MA
Period06/11/2706/12/1

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ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Lee, J., Kwon, I. C., Woo, K., & Chung, H. (2006). Biocompatible polymeric nanoparticles and films containing hydrophobic quantum dots. In Materials Research Society Symposium Proceedings (pp. 52-56). (Materials Research Society Symposium Proceedings; Vol. 950).