TY - GEN
T1 - Biocompatible polymeric nanoparticles and films containing hydrophobic quantum dots
AU - Lee, Jisook
AU - Kwon, Ick Chan
AU - Woo, Kyoungja
AU - Chung, Hesson
PY - 2006
Y1 - 2006
N2 - Micro- or nano-particles encapsulating hydrophobic quantum dots were prepared by the emulsion technique. Films containing quantum dots were also prepared by film casting methods. Quantum dots without hydrophilic coating were directly mixed with polymer solution to prepared extremely stable films or particles that do not phase-separate with time. The surface of the particles or films could be modified to have different hydrophilicity and/or functional groups. Particles with 1.5 ± 0.16 um and 320 ± 26 nm in diameters and films of 300 um in thickness were prepared. NIH 3T3 and EMT-6 were culture on the films containing quantum dots for 8 -20 h. Compared to the control, quantum dot were delivered directly and efficiently into the cells without toxicity. When implanted near tumor cells in Balb/C mice, quantum dots migrated from the films into the tumor cells for at least 3 days. Considering that the quantum dot dispersion in aqueous media is relatively unstable and difficult to handle, our stable particles or films containing hydrophobic quantum dots can become versatile probes for biological applications.
AB - Micro- or nano-particles encapsulating hydrophobic quantum dots were prepared by the emulsion technique. Films containing quantum dots were also prepared by film casting methods. Quantum dots without hydrophilic coating were directly mixed with polymer solution to prepared extremely stable films or particles that do not phase-separate with time. The surface of the particles or films could be modified to have different hydrophilicity and/or functional groups. Particles with 1.5 ± 0.16 um and 320 ± 26 nm in diameters and films of 300 um in thickness were prepared. NIH 3T3 and EMT-6 were culture on the films containing quantum dots for 8 -20 h. Compared to the control, quantum dot were delivered directly and efficiently into the cells without toxicity. When implanted near tumor cells in Balb/C mice, quantum dots migrated from the films into the tumor cells for at least 3 days. Considering that the quantum dot dispersion in aqueous media is relatively unstable and difficult to handle, our stable particles or films containing hydrophobic quantum dots can become versatile probes for biological applications.
UR - http://www.scopus.com/inward/record.url?scp=40949107416&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=40949107416&partnerID=8YFLogxK
U2 - 10.1557/proc-0950-d04-09
DO - 10.1557/proc-0950-d04-09
M3 - Conference contribution
AN - SCOPUS:40949107416
SN - 9781604234060
T3 - Materials Research Society Symposium Proceedings
SP - 52
EP - 56
BT - Materials Research Society Symposium Proceedings
PB - Materials Research Society
T2 - 2006 MRS Fall Meeting
Y2 - 27 November 2006 through 1 December 2006
ER -