Biodegradable polymer biolimus-eluting stent versus durable polymer everolimus-eluting stent in patients with acute myocardial infarction

Hyun Jong Lee, Taek Kyu Park, Young Bin Song, Young Jin Choi, Cheol Woong Yu, Jeong Hoon Yang, Joo Yong Hahn, Seung Hyuk Choi, Rak Kyeong Choi, Jin Ho Choi, Jin Sik Park, Je Sang Kim, Tae Hoon Kim, Ho Joon Jang, Sang Hoon Lee, Won Heum Shim, Young Moo Roh, Hyeon Cheol Gwon

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3 Citations (Scopus)

Abstract

Abstract Background There are limited data about long-term outcomes for biodegradable polymer biolimus-eluting stent (BES) versus durable polymer everolimus-eluting stent (EES) in patients undergoing percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI). We sought to compare the two-year efficacy and safety of BES versus EES in AMI patients. Methods A total of 707 consecutive patients with ST-segment elevation myocardial infarction and non-ST-segment elevation myocardial infarction who underwent PCI with BES (n = 171) or EES (n = 536) between July 2008 and June 2012 were enrolled in this study. The efficacy endpoint (target vessel failure; a composite of cardiac death, target vessel-related myocardial infarction, and target vessel revascularization) and the safety endpoint (a composite of all cause death, myocardial infarction, and stent thrombosis) at two years were compared in crude and propensity score-matched cohorts. Results After two years, target vessel failure occurred in 13 patients treated with BES and 49 patients treated with EES (7.6% versus 9.1%; adjusted hazard ratio [HR], 1.09; 95% confidence interval [CI], 0.58-2.04; p = 0.78). The rates of composite safety endpoint at two years were not different between two groups (BES 7.6% versus EES 10.8%; adjusted HR, 0.87; 95% CI, 0.47-1.62; p = 0.66). The rates of stent thrombosis did not differ between two groups (BES 0.6% versus EES 1.3%; adjusted HR, 0.63; 95% CI, 0.06-6.20; p = 0.69). These findings were substantiated by similar results in the propensity score-matched cohort. Conclusions In the treatment of patients with AMI, BES showed similar efficacy and safety compared to those of EES for up to two years.

Original languageEnglish
Article number19597
Pages (from-to)190-197
Number of pages8
JournalInternational Journal of Cardiology
Volume183
DOIs
Publication statusPublished - 2015 Jan 1
Externally publishedYes

Keywords

  • Biolimus-eluting stent
  • Drug-eluting stent
  • Everolimus-eluting stent
  • Myocardial infarction
  • Percutaneous coronary intervention

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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  • Cite this

    Lee, H. J., Park, T. K., Song, Y. B., Choi, Y. J., Yu, C. W., Yang, J. H., Hahn, J. Y., Choi, S. H., Choi, R. K., Choi, J. H., Park, J. S., Kim, J. S., Kim, T. H., Jang, H. J., Lee, S. H., Shim, W. H., Roh, Y. M., & Gwon, H. C. (2015). Biodegradable polymer biolimus-eluting stent versus durable polymer everolimus-eluting stent in patients with acute myocardial infarction. International Journal of Cardiology, 183, 190-197. [19597]. https://doi.org/10.1016/j.ijcard.2015.01.036