Abstract
Nature, in its wonders, presents and assembles the most intricate and delicate protein structures and this remarkable phenomenon occurs in all kingdom and phyla of life. Of these proteins, cage-like multimeric proteins provide spatial control to biological processes and also compartmentalizes compounds that may be toxic or unstable and avoids their contact with the environment. Protein-based nanocages are of particular interest because of their potential applicability as drug delivery carriers and their perfect and complex symmetry and ideal physical properties, which have stimulated researchers to engineer, modify or mimic these qualities. This article reviews various existing types of protein-based nanocages that are used for therapeutic purposes, and outlines their drug-loading mechanisms and bioengineering strategies via genetic and chemical functionalization. Through a critical evaluation of recent advances in protein nanocage-based drug delivery in vitro and in vivo, an outlook for de novo and in silico nanocage design, and also protein-based nanocage preclinical and future clinical applications will be presented.
| Original language | English |
|---|---|
| Pages (from-to) | 157-171 |
| Number of pages | 15 |
| Journal | Advanced Drug Delivery Reviews |
| Volume | 106 |
| DOIs | |
| Publication status | Published - 2016 Nov 15 |
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Keywords
- Bioengineering
- Cancer therapy
- Drug delivery
- Functionalization
- Protein-based nanocage
ASJC Scopus subject areas
- Pharmaceutical Science
Cite this
Bioengineered protein-based nanocage for drug delivery. / Lee, Eun Jung; Lee, Na Kyeong; Kim, In-San.
In: Advanced Drug Delivery Reviews, Vol. 106, 15.11.2016, p. 157-171.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Bioengineered protein-based nanocage for drug delivery
AU - Lee, Eun Jung
AU - Lee, Na Kyeong
AU - Kim, In-San
PY - 2016/11/15
Y1 - 2016/11/15
N2 - Nature, in its wonders, presents and assembles the most intricate and delicate protein structures and this remarkable phenomenon occurs in all kingdom and phyla of life. Of these proteins, cage-like multimeric proteins provide spatial control to biological processes and also compartmentalizes compounds that may be toxic or unstable and avoids their contact with the environment. Protein-based nanocages are of particular interest because of their potential applicability as drug delivery carriers and their perfect and complex symmetry and ideal physical properties, which have stimulated researchers to engineer, modify or mimic these qualities. This article reviews various existing types of protein-based nanocages that are used for therapeutic purposes, and outlines their drug-loading mechanisms and bioengineering strategies via genetic and chemical functionalization. Through a critical evaluation of recent advances in protein nanocage-based drug delivery in vitro and in vivo, an outlook for de novo and in silico nanocage design, and also protein-based nanocage preclinical and future clinical applications will be presented.
AB - Nature, in its wonders, presents and assembles the most intricate and delicate protein structures and this remarkable phenomenon occurs in all kingdom and phyla of life. Of these proteins, cage-like multimeric proteins provide spatial control to biological processes and also compartmentalizes compounds that may be toxic or unstable and avoids their contact with the environment. Protein-based nanocages are of particular interest because of their potential applicability as drug delivery carriers and their perfect and complex symmetry and ideal physical properties, which have stimulated researchers to engineer, modify or mimic these qualities. This article reviews various existing types of protein-based nanocages that are used for therapeutic purposes, and outlines their drug-loading mechanisms and bioengineering strategies via genetic and chemical functionalization. Through a critical evaluation of recent advances in protein nanocage-based drug delivery in vitro and in vivo, an outlook for de novo and in silico nanocage design, and also protein-based nanocage preclinical and future clinical applications will be presented.
KW - Bioengineering
KW - Cancer therapy
KW - Drug delivery
KW - Functionalization
KW - Protein-based nanocage
UR - http://www.scopus.com/inward/record.url?scp=84962128027&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84962128027&partnerID=8YFLogxK
U2 - 10.1016/j.addr.2016.03.002
DO - 10.1016/j.addr.2016.03.002
M3 - Review article
C2 - 26994591
AN - SCOPUS:84962128027
VL - 106
SP - 157
EP - 171
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
SN - 0169-409X
ER -