TY - JOUR
T1 - Bioengineered protein-based nanocage for drug delivery
AU - Lee, Eun Jung
AU - Lee, Na Kyeong
AU - Kim, In San
N1 - Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIP, Ministry of Science, ICT & Future Planning) (No. 2015R1A2A1A15056039 ), a grant from the National R&D Program for Cancer Control, Ministry of Health and Welfare, Republic of Korea ( 1420390 ), and the KIST Institutional Program (Project No. 2E26320 ).
Publisher Copyright:
© 2016 Elsevier B.V.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2016/11/15
Y1 - 2016/11/15
N2 - Nature, in its wonders, presents and assembles the most intricate and delicate protein structures and this remarkable phenomenon occurs in all kingdom and phyla of life. Of these proteins, cage-like multimeric proteins provide spatial control to biological processes and also compartmentalizes compounds that may be toxic or unstable and avoids their contact with the environment. Protein-based nanocages are of particular interest because of their potential applicability as drug delivery carriers and their perfect and complex symmetry and ideal physical properties, which have stimulated researchers to engineer, modify or mimic these qualities. This article reviews various existing types of protein-based nanocages that are used for therapeutic purposes, and outlines their drug-loading mechanisms and bioengineering strategies via genetic and chemical functionalization. Through a critical evaluation of recent advances in protein nanocage-based drug delivery in vitro and in vivo, an outlook for de novo and in silico nanocage design, and also protein-based nanocage preclinical and future clinical applications will be presented.
AB - Nature, in its wonders, presents and assembles the most intricate and delicate protein structures and this remarkable phenomenon occurs in all kingdom and phyla of life. Of these proteins, cage-like multimeric proteins provide spatial control to biological processes and also compartmentalizes compounds that may be toxic or unstable and avoids their contact with the environment. Protein-based nanocages are of particular interest because of their potential applicability as drug delivery carriers and their perfect and complex symmetry and ideal physical properties, which have stimulated researchers to engineer, modify or mimic these qualities. This article reviews various existing types of protein-based nanocages that are used for therapeutic purposes, and outlines their drug-loading mechanisms and bioengineering strategies via genetic and chemical functionalization. Through a critical evaluation of recent advances in protein nanocage-based drug delivery in vitro and in vivo, an outlook for de novo and in silico nanocage design, and also protein-based nanocage preclinical and future clinical applications will be presented.
KW - Bioengineering
KW - Cancer therapy
KW - Drug delivery
KW - Functionalization
KW - Protein-based nanocage
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U2 - 10.1016/j.addr.2016.03.002
DO - 10.1016/j.addr.2016.03.002
M3 - Review article
C2 - 26994591
AN - SCOPUS:84962128027
VL - 106
SP - 157
EP - 171
JO - Advanced Drug Delivery Reviews
JF - Advanced Drug Delivery Reviews
SN - 0169-409X
ER -