Biological and Genetic Markers in Occupational Asthma

Gyu Young Hur, Hae Sim Park

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Occupational asthma (OA) is a complex disease that is often hard to diagnose due to difficulties in detecting relevant exposure, along with inherent differences in disease susceptibility. Numerous studies have attempted to identify relevant biological and genetic markers for OA and to devise tools capable of detecting exposure to the causative agent. Immunological markers, including skin prick test reactivity and specific IgE and IgG antibodies can be used to detect high-molecular-weight allergens in cases of baker’s asthma. For OA induced by low-molecular-weight agents, such as isocyanate, potential biomarkers include serum-specific IgE and IgG antibodies to isocyanate-HSA conjugate and IgG to cytokeratin 19 and transglutaminase-2. For protein-based markers, ferritin/transferrin and vitamin D-binding protein levels have been suggested for isocyanate-OA. Genetic markers of susceptibility to isocyanate-OA include human leukocyte antigen and CTNNA3. Further investigations will be needed to identify better biomarkers for OA, which may be used to inform clinical decision.

Original languageEnglish
JournalCurrent Allergy and Asthma Reports
Volume15
Issue number1
DOIs
Publication statusPublished - 2015 Jan 1

Fingerprint

Occupational Asthma
Genetic Markers
Isocyanates
Biomarkers
Immunoglobulin G
Immunoglobulin E
Molecular Weight
Vitamin D-Binding Protein
Keratin-19
Antibodies
Disease Susceptibility
Genetic Predisposition to Disease
Transferrin
Ferritins
HLA Antigens
Skin Tests
Allergens
Asthma
Serum
Proteins

Keywords

  • Biomarker
  • Gene marker
  • Occupational asthma

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine

Cite this

Biological and Genetic Markers in Occupational Asthma. / Hur, Gyu Young; Park, Hae Sim.

In: Current Allergy and Asthma Reports, Vol. 15, No. 1, 01.01.2015.

Research output: Contribution to journalReview article

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