TY - JOUR
T1 - Biological effects of conjugated linoleic acid on obesity-related cancers
AU - Moon, Hyun Seuk
N1 - Funding Information:
This work was supported by Korea University Grant.
Publisher Copyright:
© 2014 Elsevier Ireland Ltd. All Right Reserved.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2014/12/5
Y1 - 2014/12/5
N2 - Considerable evidence suggests that obesity and overweight play an important role in cancers i.e., breast, colon, endometrial, kidney, pancreatic, and liver. In fact, overweight and obesity are now established risk factors for cancer and cancer-related mortality. Conjugated linoleic acid (CLA) consists of a group of positional and geometric fatty acid (FA) isomers that are derived from linoleic acid (LA) [18:2(n-6)], which occurs naturally in food with a high concentration in products from ruminant animals. Studies in both in vitro cell and in vivo animal models have shown that CLA, specifically cis 9-trans 11 and trans 10-cis 12 CLA isomer, inhibits the initiation and promotion stages of carcinogenesis, suggesting that CLA has received considerable attention as a chemopreventive agent. In this review, the biological activities and multiple mechanisms of CLA in obesity-related cancers including cell lines, animal models and clinical observations are explained.
AB - Considerable evidence suggests that obesity and overweight play an important role in cancers i.e., breast, colon, endometrial, kidney, pancreatic, and liver. In fact, overweight and obesity are now established risk factors for cancer and cancer-related mortality. Conjugated linoleic acid (CLA) consists of a group of positional and geometric fatty acid (FA) isomers that are derived from linoleic acid (LA) [18:2(n-6)], which occurs naturally in food with a high concentration in products from ruminant animals. Studies in both in vitro cell and in vivo animal models have shown that CLA, specifically cis 9-trans 11 and trans 10-cis 12 CLA isomer, inhibits the initiation and promotion stages of carcinogenesis, suggesting that CLA has received considerable attention as a chemopreventive agent. In this review, the biological activities and multiple mechanisms of CLA in obesity-related cancers including cell lines, animal models and clinical observations are explained.
KW - Conjugated linoleic acid
KW - Obesity
KW - Obesity-related cancer
KW - Signaling pathways
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U2 - 10.1016/j.cbi.2014.11.006
DO - 10.1016/j.cbi.2014.11.006
M3 - Review article
C2 - 25446861
AN - SCOPUS:84912572653
VL - 224
SP - 189
EP - 195
JO - Chemico-Biological Interactions
JF - Chemico-Biological Interactions
SN - 0009-2797
ER -
