Abstract
Considerable evidence suggests that obesity and overweight play an important role in cancers i.e., breast, colon, endometrial, kidney, pancreatic, and liver. In fact, overweight and obesity are now established risk factors for cancer and cancer-related mortality. Conjugated linoleic acid (CLA) consists of a group of positional and geometric fatty acid (FA) isomers that are derived from linoleic acid (LA) [18:2(n-6)], which occurs naturally in food with a high concentration in products from ruminant animals. Studies in both in vitro cell and in vivo animal models have shown that CLA, specifically cis 9-trans 11 and trans 10-cis 12 CLA isomer, inhibits the initiation and promotion stages of carcinogenesis, suggesting that CLA has received considerable attention as a chemopreventive agent. In this review, the biological activities and multiple mechanisms of CLA in obesity-related cancers including cell lines, animal models and clinical observations are explained.
| Original language | English |
|---|---|
| Pages (from-to) | 189-195 |
| Number of pages | 7 |
| Journal | Chemico-Biological Interactions |
| Volume | 224 |
| DOIs | |
| Publication status | Published - 2014 Dec 5 |
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ASJC Scopus subject areas
- Toxicology
Cite this
Biological effects of conjugated linoleic acid on obesity-related cancers. / Moon, Hyun-Seuk.
In: Chemico-Biological Interactions, Vol. 224, 05.12.2014, p. 189-195.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Biological effects of conjugated linoleic acid on obesity-related cancers
AU - Moon, Hyun-Seuk
PY - 2014/12/5
Y1 - 2014/12/5
N2 - Considerable evidence suggests that obesity and overweight play an important role in cancers i.e., breast, colon, endometrial, kidney, pancreatic, and liver. In fact, overweight and obesity are now established risk factors for cancer and cancer-related mortality. Conjugated linoleic acid (CLA) consists of a group of positional and geometric fatty acid (FA) isomers that are derived from linoleic acid (LA) [18:2(n-6)], which occurs naturally in food with a high concentration in products from ruminant animals. Studies in both in vitro cell and in vivo animal models have shown that CLA, specifically cis 9-trans 11 and trans 10-cis 12 CLA isomer, inhibits the initiation and promotion stages of carcinogenesis, suggesting that CLA has received considerable attention as a chemopreventive agent. In this review, the biological activities and multiple mechanisms of CLA in obesity-related cancers including cell lines, animal models and clinical observations are explained.
AB - Considerable evidence suggests that obesity and overweight play an important role in cancers i.e., breast, colon, endometrial, kidney, pancreatic, and liver. In fact, overweight and obesity are now established risk factors for cancer and cancer-related mortality. Conjugated linoleic acid (CLA) consists of a group of positional and geometric fatty acid (FA) isomers that are derived from linoleic acid (LA) [18:2(n-6)], which occurs naturally in food with a high concentration in products from ruminant animals. Studies in both in vitro cell and in vivo animal models have shown that CLA, specifically cis 9-trans 11 and trans 10-cis 12 CLA isomer, inhibits the initiation and promotion stages of carcinogenesis, suggesting that CLA has received considerable attention as a chemopreventive agent. In this review, the biological activities and multiple mechanisms of CLA in obesity-related cancers including cell lines, animal models and clinical observations are explained.
KW - Conjugated linoleic acid
KW - Obesity
KW - Obesity-related cancer
KW - Signaling pathways
UR - http://www.scopus.com/inward/record.url?scp=84912572653&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84912572653&partnerID=8YFLogxK
U2 - 10.1016/j.cbi.2014.11.006
DO - 10.1016/j.cbi.2014.11.006
M3 - Article
VL - 224
SP - 189
EP - 195
JO - Chemico-Biological Interactions
JF - Chemico-Biological Interactions
SN - 0009-2797
ER -