Biological methylation of myelin basic protein: Enzymology and biological significance

Sangduk Kim, In Kyoung Lim, Gil-Hong Park, Woon Ki Paik

Research output: Contribution to journalReview article

62 Citations (Scopus)

Abstract

Myelin is a membrane characteristic of the nervous tissue and functions as an insulator to increase the velocity of the stimuli being transmitted between a nerve cell body and its target. Myelin isolated from human and bovine nervous tissue is composed of approximatelg 80% lipid and 20% protein, and 30% of the protein fraction constitutes myelin basic protein (MBP). MBP has an unusual amino acid at Res-107 as a mixture of N(G)-monomethylarginine and N(G), N(G)-dimethylarginine. The formation of these methylarginine derivatives is catalysed by one of the subtypes of protein methylase I, which specifically methylates Res-107 of this protein. Evidence is presented to demonstrate an involvement of this biological methylation in the integrity and maintenance of myelin.

Original languageEnglish
Pages (from-to)743-751
Number of pages9
JournalInternational Journal of Biochemistry and Cell Biology
Volume29
Issue number5
DOIs
Publication statusPublished - 1997 May 1

Fingerprint

Methylation
Myelin Basic Protein
Myelin Sheath
Nerve Tissue
Protein-Arginine N-Methyltransferases
Tissue
omega-N-Methylarginine
Proteins
Neurons
Maintenance
Derivatives
Membranes
Lipids
Amino Acids

Keywords

  • MBP methylation
  • Multiple sclerosis
  • Myelin basic protein
  • Protein-arginine methylation

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

Cite this

Biological methylation of myelin basic protein : Enzymology and biological significance. / Kim, Sangduk; Lim, In Kyoung; Park, Gil-Hong; Paik, Woon Ki.

In: International Journal of Biochemistry and Cell Biology, Vol. 29, No. 5, 01.05.1997, p. 743-751.

Research output: Contribution to journalReview article

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