Biological methylation of myelin basic protein: Enzymology and biological significance

Sangduk Kim, In Kyoung Lim, Gil Hong Park, Woon Ki Paik

    Research output: Contribution to journalReview articlepeer-review

    66 Citations (Scopus)

    Abstract

    Myelin is a membrane characteristic of the nervous tissue and functions as an insulator to increase the velocity of the stimuli being transmitted between a nerve cell body and its target. Myelin isolated from human and bovine nervous tissue is composed of approximatelg 80% lipid and 20% protein, and 30% of the protein fraction constitutes myelin basic protein (MBP). MBP has an unusual amino acid at Res-107 as a mixture of N(G)-monomethylarginine and N(G), N(G)-dimethylarginine. The formation of these methylarginine derivatives is catalysed by one of the subtypes of protein methylase I, which specifically methylates Res-107 of this protein. Evidence is presented to demonstrate an involvement of this biological methylation in the integrity and maintenance of myelin.

    Original languageEnglish
    Pages (from-to)743-751
    Number of pages9
    JournalInternational Journal of Biochemistry and Cell Biology
    Volume29
    Issue number5
    DOIs
    Publication statusPublished - 1997 May

    Keywords

    • MBP methylation
    • Multiple sclerosis
    • Myelin basic protein
    • Protein-arginine methylation

    ASJC Scopus subject areas

    • Biochemistry
    • Cell Biology

    Fingerprint

    Dive into the research topics of 'Biological methylation of myelin basic protein: Enzymology and biological significance'. Together they form a unique fingerprint.

    Cite this