Biomarkers of major depression related to serotonin receptors

Meysam Amidfar, Lejla Colic, Martin Walter, Yong Ku Kim

Research output: Contribution to journalArticle

Abstract

Background: Developing group of recent findings demonstrate that serotonin receptors play a significant pathophysiological role in major depressive disorder (MDD). Objective: This article will briefly review the literature concerning mechanisms of action, brain distribution and localization of 5HT receptor subtypes and their changes in patients with MDD, as reported via neuroimaging, postmortem and genetic studies. Method: Postmortem brain researches, neuroimaging PET studies and genetic polymorphism studies in suicide and depression were examined in order to explore the role of 5-HT receptor subtypes in the neurobiology of major depression as possibly beneficial biomarkers for diagnosis and treatment response in MDD. Results: Reported significant association between Gene polymorphisms of 5-HT receptors including 5-HT1A, 5-HT1B, 5-HT3, 5HT4 and 5HT6 and diagnosis and treatment response in depression suggests these serotonin receptor subtypes as important therapeutic and diagnostic markers for depression. Neuroimaging studies by PET revealed a higher rostrally and lower caudally binding potential of 5-HT1A receptor in the dorsal raphe nucleus in patients with suicidal depression, decreased potential binding of 5-HT1B receptor and elevated binding potential of cortical 5-HT2A receptors. Postmortem studies reported an elevated abundance of 5-HT2A receptors in the prefrontal cortex, altered mRNA encoding editing of 5-HT2C receptors in the prefrontal cortex and higher levels of 5HT4 receptor binding in frontal cortex and caudate nucleus of depressed suicide victims. Conclusion: 5-HT receptors including 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C, 5-HT3, 5-HT4 and 5- HT6 are involved in the neurobiology of major depression and might be beneficial biomarkers for diagnosis and treatment response in MDD and will help the development of future treatments.

Original languageEnglish
Pages (from-to)239-244
Number of pages6
JournalCurrent Psychiatry Reviews
Volume14
Issue number4
DOIs
Publication statusPublished - 2018 Jan 1

Fingerprint

Serotonin Receptors
Biomarkers
Major Depressive Disorder
Depression
Neuroimaging
Receptor, Serotonin, 5-HT2A
Neurobiology
Prefrontal Cortex
Suicide
Receptor, Serotonin, 5-HT2C
Receptor, Serotonin, 5-HT1B
Therapeutics
Receptor, Serotonin, 5-HT1A
Caudate Nucleus
Brain
Frontal Lobe
Genetic Polymorphisms
Messenger RNA
Research
Genes

Keywords

  • 5-HT receptors
  • Genetic investigations
  • Major depression
  • Neuroimaging
  • Postmortem brain
  • Serotonin receptors

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Biomarkers of major depression related to serotonin receptors. / Amidfar, Meysam; Colic, Lejla; Walter, Martin; Kim, Yong Ku.

In: Current Psychiatry Reviews, Vol. 14, No. 4, 01.01.2018, p. 239-244.

Research output: Contribution to journalArticle

Amidfar, Meysam ; Colic, Lejla ; Walter, Martin ; Kim, Yong Ku. / Biomarkers of major depression related to serotonin receptors. In: Current Psychiatry Reviews. 2018 ; Vol. 14, No. 4. pp. 239-244.
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