Biophysical characterization of cofilin-induced extension-torsion coupling in actin filaments

Jae In Kim, Junpyo Kwon, Inchul Baek, Sung Soo Na

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Cofilin makes the actin filament flexible and thermally unstable by disassembling the filament and inducing bending and torsional compliance. Actin monomers bound to cofilin are able to chemically and mechanically interact in response to external forces. In this study, we performed two molecular dynamics tensile tests for actin and cofilactin filaments under identical conditions. Surprisingly, cofilactin filaments were found to be twisted, generating shear stress caused by torsion. Additionally, analysis by plane stress assumption indicated that the extension-torsion coupling effect increases the amount of principal stress by 10%. Using elasticity and solid mechanics theories, our study elucidates the role of cofilin in the disassembly of actin filaments under tensile forces.

Original languageEnglish
Pages (from-to)1831-1835
Number of pages5
JournalJournal of Biomechanics
Volume49
Issue number9
DOIs
Publication statusPublished - 2016 Jun 14

Fingerprint

Actin Depolymerizing Factors
Actin Cytoskeleton
Torsional stress
Molecular dynamics
Shear stress
Elasticity
Mechanics
Monomers
Molecular Dynamics Simulation
Compliance
Actins

Keywords

  • Actin
  • Cofilin
  • Coupling effect
  • Extension
  • SMD
  • Torsion

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Rehabilitation
  • Biophysics
  • Biomedical Engineering

Cite this

Biophysical characterization of cofilin-induced extension-torsion coupling in actin filaments. / Kim, Jae In; Kwon, Junpyo; Baek, Inchul; Na, Sung Soo.

In: Journal of Biomechanics, Vol. 49, No. 9, 14.06.2016, p. 1831-1835.

Research output: Contribution to journalArticle

Kim, Jae In ; Kwon, Junpyo ; Baek, Inchul ; Na, Sung Soo. / Biophysical characterization of cofilin-induced extension-torsion coupling in actin filaments. In: Journal of Biomechanics. 2016 ; Vol. 49, No. 9. pp. 1831-1835.
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