Biophysical Model Including a Potentially Lethal Damage Repair Parameter in Fractionated Carbon Beam

Eunae Choi, Myonggeun Yoon, Masao Suzuki, Naruhiro Matsufuji, Wonguyn Jung

Research output: Contribution to journalArticle

Abstract

The amount of potentially lethal damage repair (PLDR) is a significant factor in the process of modeling the survival curves of cells irradiated with fractionated carbon beams. Because the amount of PLDR generally depends on the features of the cells and the linear energy transfer (LET), the amount of PLDR of cells irradiated with fractionated carbon beams shows distinct differences from that of cells irradiated with X-rays. This study considered a new parameter dependent on the correlation between the PLDR trait (T) of the cells over a time interval (Δ) at the fractionated carbon beam irradiation. The survival curves of the cells irradiated with fractionated carbon beams n times were predicted using the ζ and the Ψ values from the delay assay. This study aims to overcome the barriers of traditional methods by developing a new survival curve model with new parameters based on an analysis of the PLDR traits of cells over time interval in fractionated carbon beam irradiation and to suggest a model that produces results significantly closer to the experimental data.

Original languageEnglish
Pages (from-to)161-167
Number of pages7
JournalJournal of the Korean Physical Society
Volume77
Issue number2
DOIs
Publication statusPublished - 2020 Jul 1

Keywords

  • Biophysical modeling
  • Carbon beam
  • PLDR

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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