Bioresorbable elastomeric vascular tissue engineering scaffolds via melt spinning and electrospinning

Sangwon Chung, Nilesh P. Ingle, Gerardo A. Montero, Soo Hyun Kim, Martin W. King

Research output: Contribution to journalArticle

104 Citations (Scopus)

Abstract

Current surgical therapy for diseased vessels less than 6 mm in diameter involves bypass grafting with autologous arteries or veins. Although this surgical practice is common, it has significant limitations and complications, such as occlusion, intimal hyperplasia and compliance mismatch. As a result, cardiovascular biomaterials research has been motivated to develop tissue-engineered blood vessel substitutes. In this study, vascular tissue engineering scaffolds were fabricated using two different approaches, namely melt spinning and electrospinning. Small diameter tubes were fabricated from an elastomeric bioresorbable 50:50 poly(L-lactide-co-ε-caprolactone) copolymer having dimensions of 5 mm in diameter and porosity of over 75%. Scaffolds electrospun from two different solvents, acetone and 1,1,1,3,3,3-hexafluoro-2- propanol were compared in terms of their morphology, mechanical properties and cell viability. Overall, the mechanical properties of the prototype tubes exceeded the transverse tensile values of natural arteries of similar caliber. In addition to spinning the polymer separately into melt-spun and electrospun constructs, the approach in this study has successfully demonstrated that these two techniques can be combined to produce double-layered tubular scaffolds containing both melt-spun macrofibers (<200 μm in diameter) and electrospun submicron fibers (>400 nm in diameter). Since the vascular wall has a complex multilayered architecture and unique mechanical properties, there remain several significant challenges before a successful tissue-engineered artery is achieved.

Original languageEnglish
Pages (from-to)1958-1967
Number of pages10
JournalActa Biomaterialia
Volume6
Issue number6
DOIs
Publication statusPublished - 2010 Jun

Keywords

  • Elastomeric PLCL
  • Electrospinning
  • Melt spinning
  • Tissue engineering scaffolds

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering
  • Molecular Biology

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