Biosensor system-on-a-chip including CMOS-based signal processing circuits and 64 carbon nanotube-based sensors for the detection of a neurotransmitter

Byung Yang Lee, Sung Min Seo, Dong Joon Lee, Minbaek Lee, Joohyung Lee, Jun Ho Cheon, Eunju Cho, Hyunjoong Lee, In Young Chung, Young June Park, Suhwan Kim, Seunghun Hong

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

We developed a carbon nanotube (CNT)-based biosensor system-on-a-chip (SoC) for the detection of a neurotransmitter. Here, 64 CNT-based sensors were integrated with silicon-based signal processing circuits in a single chip, which was made possible by combining several technological breakthroughs such as efficient signal processing, uniform CNT networks, and biocompatible functionalization of CNT-based sensors. The chip was utilized to detect glutamate, a neurotransmitter, where ammonia, a byproduct of the enzymatic reaction of glutamate and glutamate oxidase on CNT-based sensors, modulated the conductance signals to the CNT-based sensors. This is a major technological advancement in the integration of CNT-based sensors with microelectronics, and this chip can be readily integrated with larger scale lab-on-a-chip (LoC) systems for various applications such as LoC systems for neural networks.

Original languageEnglish
Pages (from-to)894-898
Number of pages5
JournalLab on a Chip - Miniaturisation for Chemistry and Biology
Volume10
Issue number7
DOIs
Publication statusPublished - 2010 Mar 29
Externally publishedYes

Fingerprint

Carbon Nanotubes
Biosensing Techniques
Biosensors
Neurotransmitter Agents
Carbon nanotubes
Signal processing
Networks (circuits)
Sensors
Glutamic Acid
Lab-on-a-chip
Silicon
Ammonia
Microelectronics
Byproducts
Oxidoreductases
Neural networks

ASJC Scopus subject areas

  • Biochemistry
  • Chemistry(all)
  • Bioengineering
  • Biomedical Engineering

Cite this

Biosensor system-on-a-chip including CMOS-based signal processing circuits and 64 carbon nanotube-based sensors for the detection of a neurotransmitter. / Lee, Byung Yang; Seo, Sung Min; Lee, Dong Joon; Lee, Minbaek; Lee, Joohyung; Cheon, Jun Ho; Cho, Eunju; Lee, Hyunjoong; Chung, In Young; Park, Young June; Kim, Suhwan; Hong, Seunghun.

In: Lab on a Chip - Miniaturisation for Chemistry and Biology, Vol. 10, No. 7, 29.03.2010, p. 894-898.

Research output: Contribution to journalArticle

Lee, Byung Yang ; Seo, Sung Min ; Lee, Dong Joon ; Lee, Minbaek ; Lee, Joohyung ; Cheon, Jun Ho ; Cho, Eunju ; Lee, Hyunjoong ; Chung, In Young ; Park, Young June ; Kim, Suhwan ; Hong, Seunghun. / Biosensor system-on-a-chip including CMOS-based signal processing circuits and 64 carbon nanotube-based sensors for the detection of a neurotransmitter. In: Lab on a Chip - Miniaturisation for Chemistry and Biology. 2010 ; Vol. 10, No. 7. pp. 894-898.
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