Biosynthesis of the heat-shock protein 90 inhibitor geldanamycin: New insight into the formation of the benzoquinone moiety

Dongho Lee, Kyeong Lee, Xing Fu Cai, Nguyen Tien Dat, Shanthaveerappa K. Boovanahalli, Mijeoung Lee, Jin Chul Shin, Woncheol Kim, Jae Kap Jeong, Jong Suk Lee, Choong Hwan Lee, Jeong Hyung Lee, Young Soo Hong, Jung Joon Lee

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

A clue towards determining the biosynthetic origin of ansamycin benzoquinone formation by spontaneous oxidation from a corresponding hydroquinone has been provided by ACDL3172 (1), a tricyclic geldanamycin derivative produced by the gel8 gene-inactivated strain of S. hygroscopicus subsp. duamyceticus JCM4427.

Original languageEnglish
Pages (from-to)246-248
Number of pages3
JournalChemBioChem
Volume7
Issue number2
DOIs
Publication statusPublished - 2006 Feb 1
Externally publishedYes

Fingerprint

Rifabutin
HSP90 Heat-Shock Proteins
Biosynthesis
Genes
Derivatives
Oxidation
benzoquinone
geldanamycin
hydroquinone

Keywords

  • Antitumor agents
  • Autooxidation
  • Biosynthesis
  • Polyketides

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Biosynthesis of the heat-shock protein 90 inhibitor geldanamycin : New insight into the formation of the benzoquinone moiety. / Lee, Dongho; Lee, Kyeong; Cai, Xing Fu; Dat, Nguyen Tien; Boovanahalli, Shanthaveerappa K.; Lee, Mijeoung; Shin, Jin Chul; Kim, Woncheol; Jeong, Jae Kap; Lee, Jong Suk; Lee, Choong Hwan; Lee, Jeong Hyung; Hong, Young Soo; Lee, Jung Joon.

In: ChemBioChem, Vol. 7, No. 2, 01.02.2006, p. 246-248.

Research output: Contribution to journalArticle

Lee, D, Lee, K, Cai, XF, Dat, NT, Boovanahalli, SK, Lee, M, Shin, JC, Kim, W, Jeong, JK, Lee, JS, Lee, CH, Lee, JH, Hong, YS & Lee, JJ 2006, 'Biosynthesis of the heat-shock protein 90 inhibitor geldanamycin: New insight into the formation of the benzoquinone moiety', ChemBioChem, vol. 7, no. 2, pp. 246-248. https://doi.org/10.1002/cbic.200500441
Lee, Dongho ; Lee, Kyeong ; Cai, Xing Fu ; Dat, Nguyen Tien ; Boovanahalli, Shanthaveerappa K. ; Lee, Mijeoung ; Shin, Jin Chul ; Kim, Woncheol ; Jeong, Jae Kap ; Lee, Jong Suk ; Lee, Choong Hwan ; Lee, Jeong Hyung ; Hong, Young Soo ; Lee, Jung Joon. / Biosynthesis of the heat-shock protein 90 inhibitor geldanamycin : New insight into the formation of the benzoquinone moiety. In: ChemBioChem. 2006 ; Vol. 7, No. 2. pp. 246-248.
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