Biosynthesis of the heat-shock protein 90 inhibitor geldanamycin: New insight into the formation of the benzoquinone moiety

Dongho Lee, Kyeong Lee, Xing Fu Cai, Nguyen Tien Dat, Shanthaveerappa K. Boovanahalli, Mijeoung Lee, Jin Chul Shin, Woncheol Kim, Jae Kap Jeong, Jong Suk Lee, Choong Hwan Lee, Jeong Hyung Lee, Young Soo Hong, Jung Joon Lee

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

A clue towards determining the biosynthetic origin of ansamycin benzoquinone formation by spontaneous oxidation from a corresponding hydroquinone has been provided by ACDL3172 (1), a tricyclic geldanamycin derivative produced by the gel8 gene-inactivated strain of S. hygroscopicus subsp. duamyceticus JCM4427.

Original languageEnglish
Pages (from-to)246-248
Number of pages3
JournalChemBioChem
Volume7
Issue number2
DOIs
Publication statusPublished - 2006 Feb

Keywords

  • Antitumor agents
  • Autooxidation
  • Biosynthesis
  • Polyketides

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Organic Chemistry

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  • Cite this

    Lee, D., Lee, K., Cai, X. F., Dat, N. T., Boovanahalli, S. K., Lee, M., Shin, J. C., Kim, W., Jeong, J. K., Lee, J. S., Lee, C. H., Lee, J. H., Hong, Y. S., & Lee, J. J. (2006). Biosynthesis of the heat-shock protein 90 inhibitor geldanamycin: New insight into the formation of the benzoquinone moiety. ChemBioChem, 7(2), 246-248. https://doi.org/10.1002/cbic.200500441