Biosynthetic pathways of aminoglycosides and their engineering

Je Won Park, Yeon Hee Ban, Sang Jip Nam, Sun Shin Cha, Yeo Joon Yoon

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Despite decades long clinical usage, aminoglycosides still remain a valuable pharmaceutical source for fighting Gram-negative bacterial pathogens, and their newly identified bioactivities are also renewing interest in this old class of antibiotics. As Nature's gift, some aminoglycosides possess natural defensive structural elements that can circumvent drug resistance mechanisms. Thus, a detailed understanding of aminoglycoside biosynthesis will enable us to apply Nature's biosynthetic strategy towards expanding structural diversity in order to produce novel and more robust aminoglycoside analogs. The engineered biosynthesis of novel aminoglycosides is required not only to develop effective therapeutics against the emerging ‘superbugs’ but also to reinvigorate antibiotic lead discovery in readiness for the emerging post-antibiotic era.

Original languageEnglish
Pages (from-to)33-41
Number of pages9
JournalCurrent Opinion in Biotechnology
Volume48
DOIs
Publication statusPublished - 2017 Dec 1

Fingerprint

Biosynthetic Pathways
Aminoglycosides
Antibiotics
Biosynthesis
Anti-Bacterial Agents
Gift Giving
Pathogens
Bioactivity
Drug Resistance
Pharmaceutical Preparations
Drug products

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

Cite this

Biosynthetic pathways of aminoglycosides and their engineering. / Park, Je Won; Ban, Yeon Hee; Nam, Sang Jip; Cha, Sun Shin; Yoon, Yeo Joon.

In: Current Opinion in Biotechnology, Vol. 48, 01.12.2017, p. 33-41.

Research output: Contribution to journalReview article

Park, Je Won ; Ban, Yeon Hee ; Nam, Sang Jip ; Cha, Sun Shin ; Yoon, Yeo Joon. / Biosynthetic pathways of aminoglycosides and their engineering. In: Current Opinion in Biotechnology. 2017 ; Vol. 48. pp. 33-41.
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