Biotin-guided anticancer drug delivery with acidity-triggered drug release

Soyeon Park, Eunjin Kim, Won Young Kim, Chulhun Kang, Jong Seung Kim

Research output: Contribution to journalArticlepeer-review

41 Citations (Scopus)

Abstract

A novel biotin-guided anticancer drug delivery system, prodrug 9, consisting of biotin, nitrobenzene, and doxorubicin, with acid-triggered drug releasing capability was synthesized. Its cellular uptake and anticancer activity are selective to the HepG2 cell line over the WI-38 cell line, as revealed by fluorescence confocal microscopic experiments and MTT assay.

Original languageEnglish
Pages (from-to)9343-9345
Number of pages3
JournalChemical Communications
Volume51
Issue number45
DOIs
Publication statusPublished - 2015 Jun 7

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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