Biotin-guided anticancer drug delivery with acidity-triggered drug release

Soyeon Park, Eunjin Kim, Won Young Kim, Chulhun Kang, Jong Seung Kim

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

A novel biotin-guided anticancer drug delivery system, prodrug 9, consisting of biotin, nitrobenzene, and doxorubicin, with acid-triggered drug releasing capability was synthesized. Its cellular uptake and anticancer activity are selective to the HepG2 cell line over the WI-38 cell line, as revealed by fluorescence confocal microscopic experiments and MTT assay.

Original languageEnglish
Pages (from-to)9343-9345
Number of pages3
JournalChemical Communications
Volume51
Issue number45
DOIs
Publication statusPublished - 2015 Jun 7

Fingerprint

Biotin
Drug delivery
Acidity
Cells
Cell Line
Nitrobenzene
Prodrugs
Hep G2 Cells
Drug Delivery Systems
Pharmaceutical Preparations
Doxorubicin
Assays
Fluorescence
Acids
Experiments
Drug Liberation
nitrobenzene

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Ceramics and Composites
  • Electronic, Optical and Magnetic Materials
  • Surfaces, Coatings and Films
  • Materials Chemistry
  • Metals and Alloys

Cite this

Biotin-guided anticancer drug delivery with acidity-triggered drug release. / Park, Soyeon; Kim, Eunjin; Kim, Won Young; Kang, Chulhun; Kim, Jong Seung.

In: Chemical Communications, Vol. 51, No. 45, 07.06.2015, p. 9343-9345.

Research output: Contribution to journalArticle

Park, Soyeon ; Kim, Eunjin ; Kim, Won Young ; Kang, Chulhun ; Kim, Jong Seung. / Biotin-guided anticancer drug delivery with acidity-triggered drug release. In: Chemical Communications. 2015 ; Vol. 51, No. 45. pp. 9343-9345.
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