Biotransformation of rosamicin antibiotic into 10,11-dihydrorosamicin with enhanced in vitro antibacterial activity against MRSA

Nguyen Lan Huong, Nguyen Huu Hoang, Anil Shrestha, Jae Kyung Sohng, Yeo Joon Yoon, Je Won Park

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A biotransformation approach using microbes as biocatalysts can be an efficient tool for the targeted modification of existing antibiotic chemical scaffolds to create previously uncharacterized therapeutic agents. By employing a recombinant Streptomyces venezuelae strain as a microbial catalyst, a reduced macrolide, 10,11-dihydrorosamicin, was created from rosamicin macrolide. Its chemical structure was spectroscopically elucidated, and the new rosamicin analog showed 2-4-fold higher antibacterial activity against two strains of methicillin-resistant Staphylococcus aureus compared with its parent rosamicin. This kind of biocatalytic approach is able to expand existing antibiotic entities and can also provide more diverse therapeutic resources.

Original languageEnglish
Pages (from-to)44-47
Number of pages4
JournalJournal of microbiology and biotechnology
Volume24
Issue number1
DOIs
Publication statusPublished - 2014
Externally publishedYes

Keywords

  • 10,11-dihydrorosamicin
  • Enhanced anti-MRSA activity
  • Microbial catalyst
  • Reduced macrolide antibiotic
  • Streptomyces venezuelae

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology

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