Bisbakuchiols A and B, novel dimeric meroterpenoids from Psoralea corylifolia

Cheng Zhu Wu, Xing Fu Cai, Nguyen Tien Dat, Seong Su Hong, Ah Reum Han, Eun Kyoung Seo, Bang Yeon Hwang, Ji Xing Nan, Dongho Lee, Jung Joon Lee

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Two novel dimeric meroterpenoids, bisbakuchiols A and B, along with (S)-bakuchiol were isolated from the seeds of Psoralea corylifolia L. (Fabaceae). Bisbakuchiols A and B contain an unprecedented dimeric meroterpenoid skeleton in which two meroterpenes are linked through a dioxane bridge. All compounds were evaluated for their potential to inhibit hypoxia-inducible factor-1 (HIF-1) activation induced by hypoxia in a HIF-1-mediated reporter gene assay in AGS human gastric cancer cells. (S)-Bakuchiol inhibited hypoxic activation of HIF-1 with an IC50 value of 6.1 μM.

Original languageEnglish
Pages (from-to)8861-8864
Number of pages4
JournalTetrahedron Letters
Volume48
Issue number50
DOIs
Publication statusPublished - 2007 Dec 10

Fingerprint

Psoralea
Hypoxia-Inducible Factor 1
Chemical activation
Reporter Genes
Skeleton
Fabaceae
Inhibitory Concentration 50
Stomach Neoplasms
Seed
Assays
Seeds
Genes
Cells
bakuchiol

Keywords

  • Fabaceae
  • Hypoxia-inducible factor-1
  • Meroterpenoid
  • Psoralea corylifolia

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Wu, C. Z., Cai, X. F., Dat, N. T., Hong, S. S., Han, A. R., Seo, E. K., ... Lee, J. J. (2007). Bisbakuchiols A and B, novel dimeric meroterpenoids from Psoralea corylifolia. Tetrahedron Letters, 48(50), 8861-8864. https://doi.org/10.1016/j.tetlet.2007.10.059

Bisbakuchiols A and B, novel dimeric meroterpenoids from Psoralea corylifolia. / Wu, Cheng Zhu; Cai, Xing Fu; Dat, Nguyen Tien; Hong, Seong Su; Han, Ah Reum; Seo, Eun Kyoung; Hwang, Bang Yeon; Nan, Ji Xing; Lee, Dongho; Lee, Jung Joon.

In: Tetrahedron Letters, Vol. 48, No. 50, 10.12.2007, p. 8861-8864.

Research output: Contribution to journalArticle

Wu, CZ, Cai, XF, Dat, NT, Hong, SS, Han, AR, Seo, EK, Hwang, BY, Nan, JX, Lee, D & Lee, JJ 2007, 'Bisbakuchiols A and B, novel dimeric meroterpenoids from Psoralea corylifolia', Tetrahedron Letters, vol. 48, no. 50, pp. 8861-8864. https://doi.org/10.1016/j.tetlet.2007.10.059
Wu, Cheng Zhu ; Cai, Xing Fu ; Dat, Nguyen Tien ; Hong, Seong Su ; Han, Ah Reum ; Seo, Eun Kyoung ; Hwang, Bang Yeon ; Nan, Ji Xing ; Lee, Dongho ; Lee, Jung Joon. / Bisbakuchiols A and B, novel dimeric meroterpenoids from Psoralea corylifolia. In: Tetrahedron Letters. 2007 ; Vol. 48, No. 50. pp. 8861-8864.
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AU - Seo, Eun Kyoung

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