Bisphenol A induces a profile of tumor aggressiveness in high-risk cells from breast cancer patients

Shanaz H. Dairkee, Junhee Seok, Stacey Champion, Aejaz Sayeed, Michael Mindrinos, Wenzhong Xiao, Ronald W. Davis, William H. Goodson

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Breast cancer outcome is highly variable. Whether inadvertent exposure to environmental xenobiotics evokes a biological response promoting cancer aggressiveness and a higher probability of tumor recurrence remains unknown. To determine specific molecular alterations which arise in high-risk breast tissue in the presence of the ubiquitous xenoestrogen, bisphenol A (BPA), we used nonmalignant random periareolar fine-needle aspirates in a novel functional assay. Early events induced by BPA in epithelial-stromal cocultures derived from the contralateral tissue of patients with breast cancer included gene expression patterns which facilitate apoptosis evasion, endurance of microenvironmental stress, and cell cycle deregulation without a detectable increase in cell numbers. This BPA response profile was significantly associated with breast tumors characterized by high histologic grade (P < 0.001) and large tumor size (P = 0.002), resulting in decreased recurrence-free patient survival (P < 0.001). Our assays show a biological "fingerprint" of probable prior exposure to endocrine-disrupting agents, and suggest a scenario in which their presence in the microenvironmental milieu of high-risk breast tissue could play a deterministic role in establishing and maintaining tumor aggressiveness and poor patient outcome.

Original languageEnglish
Pages (from-to)2076-2080
Number of pages5
JournalCancer Research
Volume68
Issue number7
DOIs
Publication statusPublished - 2008 Apr 1
Externally publishedYes

Fingerprint

Breast Neoplasms
Neoplasms
Breast
Recurrence
Neoplasm Genes
Environmental Exposure
Dermatoglyphics
Xenobiotics
Coculture Techniques
Needles
Cell Cycle
Cell Count
Apoptosis
Gene Expression
Survival
bisphenol A

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Dairkee, S. H., Seok, J., Champion, S., Sayeed, A., Mindrinos, M., Xiao, W., ... Goodson, W. H. (2008). Bisphenol A induces a profile of tumor aggressiveness in high-risk cells from breast cancer patients. Cancer Research, 68(7), 2076-2080. https://doi.org/10.1158/0008-5472.CAN-07-6526

Bisphenol A induces a profile of tumor aggressiveness in high-risk cells from breast cancer patients. / Dairkee, Shanaz H.; Seok, Junhee; Champion, Stacey; Sayeed, Aejaz; Mindrinos, Michael; Xiao, Wenzhong; Davis, Ronald W.; Goodson, William H.

In: Cancer Research, Vol. 68, No. 7, 01.04.2008, p. 2076-2080.

Research output: Contribution to journalArticle

Dairkee, SH, Seok, J, Champion, S, Sayeed, A, Mindrinos, M, Xiao, W, Davis, RW & Goodson, WH 2008, 'Bisphenol A induces a profile of tumor aggressiveness in high-risk cells from breast cancer patients', Cancer Research, vol. 68, no. 7, pp. 2076-2080. https://doi.org/10.1158/0008-5472.CAN-07-6526
Dairkee, Shanaz H. ; Seok, Junhee ; Champion, Stacey ; Sayeed, Aejaz ; Mindrinos, Michael ; Xiao, Wenzhong ; Davis, Ronald W. ; Goodson, William H. / Bisphenol A induces a profile of tumor aggressiveness in high-risk cells from breast cancer patients. In: Cancer Research. 2008 ; Vol. 68, No. 7. pp. 2076-2080.
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